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Particular focus was given to <jats:italic>A.\u00a0atrata<\/jats:italic>, which has hardly been studied so far. Based on the metabolite profile, <jats:italic>A.\u00a0atrata<\/jats:italic> exhibited more similarities to <jats:italic>A.\u00a0moschata<\/jats:italic> than to <jats:italic>A.\u00a0millefolium<\/jats:italic>. The former two only differed in the occurrence of four compounds. The flavonols syringetin-3-<jats:italic>O<\/jats:italic>-glucoside and mearnsetin-hexoside, not reported for an <jats:italic>Achillea<\/jats:italic> species before, have been detected in <jats:italic>A.\u00a0atrata<\/jats:italic> and <jats:italic>A.\u00a0moschata<\/jats:italic>. All <jats:italic>Achillea<\/jats:italic> species reduced growth of the tested bacteria. <jats:italic>A.\u00a0atrata<\/jats:italic> demonstrated highest activity against <jats:italic>Propionibacterium acnes<\/jats:italic> and <jats:italic>Staphylococcus epidermidis<\/jats:italic>, both being involved in the pathogenesis of acne vulgaris. Furthermore, <jats:italic>A.\u00a0atrata<\/jats:italic> has a pronounced anti\u2013methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> potential. Bioassay-guided fractionation revealed that only the most polar fraction of <jats:italic>A.\u00a0moschata<\/jats:italic> displayed antimicrobial activity, which was attributed to phenolics such as apigenin, centaureidin, and nevadensin, being present in high amounts in <jats:italic>A.\u00a0atrata<\/jats:italic>. Thus, this alpine species shows promising antimicrobial activity and might be a potential source for developing novel dermal\/topical drugs.<\/jats:p>","DOI":"10.1515\/znc-2020-0149","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T05:59:56Z","timestamp":1599803996000},"page":"55-65","source":"Crossref","is-referenced-by-count":28,"title":["Phytochemical characterization of different yarrow species (<i>Achillea<\/i> sp.) and investigations into their antimicrobial activity"],"prefix":"10.1515","volume":"76","author":[{"given":"Lysanne","family":"Apel","sequence":"first","affiliation":[{"name":"Department of Analytical Development & Research, WALA Heilmittel GmbH , Section Phytochemical Research, Bad Boll , Eckw\u00e4lden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of Analytical Development & Research, WALA Heilmittel GmbH , Section Phytochemical Research, Bad Boll , Eckw\u00e4lden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Urban","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences , Eberhard-Karls-University , Tuebingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Analytical Development & Research, WALA Heilmittel GmbH , Section Phytochemical Research, Bad Boll , Eckw\u00e4lden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otmar","family":"Spring","sequence":"additional","affiliation":[{"name":"Institute of Botany , Hohenheim University , Stuttgart , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian C.","family":"Stintzing","sequence":"additional","affiliation":[{"name":"Department of Analytical Development & Research, WALA Heilmittel GmbH , Section Phytochemical Research, Bad Boll , Eckw\u00e4lden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar R.","family":"Kammerer","sequence":"additional","affiliation":[{"name":"Department of Analytical Development & Research, WALA Heilmittel GmbH , Section Phytochemical Research, Bad Boll , Eckw\u00e4lden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"2021072720012467259_j_znc-2020-0149_ref_001_w2aab3b7c63b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Nemeth, E, Bernath, J. 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