{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:50:52Z","timestamp":1792788652626,"version":"4.5.0"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"9-10","funder":[{"name":"Science and Engineering Research Board, Department of Science & Technology, Government of India","award":["SB\/FT\/LS-300\/2012"],"award-info":[{"award-number":["SB\/FT\/LS-300\/2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Cinnamomum tamala<\/jats:italic>\n                    and\n                    <jats:italic>Cinnamomum verum<\/jats:italic>\n                    are known for their folk medicinal usage in treating gastrointestinal ailments. The spasmolytic activity of essential oils was studied using isolated rat ileum. The results indicate that\n                    <jats:italic>C.\u00a0tamala<\/jats:italic>\n                    , despite having a lower content of eugenol (60%), shows a spasmolytic potential of 68.01\u00a0\u00b1\u00a02.63% (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a0110.12\u00a0\u00b1\u00a013.58\u00a0\u03bcg\/mL) while\n                    <jats:italic>C.\u00a0verum<\/jats:italic>\n                    with rich eugenol (80%) shows lesser spasmolytic potential (38.96\u00a0\u00b1\u00a00.63%) and fails to attain an EC\n                    <jats:sub>50<\/jats:sub>\n                    value. Upon comparison with standard eugenol\u2019s percentage of spasmolytic (35.68\u00a0\u00b1\u00a02.57%), it is evident that the action of these essential oils does not solely rely on the major component but the synergistic role in association with other components of the mixture influences the pharmacological action of the essential oils.\n                    <jats:italic>In silico<\/jats:italic>\n                    docking of phytochemicals of leaf essential oils with M\n                    <jats:sub>2<\/jats:sub>\n                    (M\n                    <jats:sub>2<\/jats:sub>\n                    AChR) and M\n                    <jats:sub>3<\/jats:sub>\n                    muscarinic (M\n                    <jats:sub>3<\/jats:sub>\n                    AChR) and nicotinic acetylcholine receptor (nAChR) was carried out to determine the type of receptors through which the essential oils had spasmolytic potential. The binding affinity for eugenol with nAChR shows a better docking score than M\n                    <jats:sub>2<\/jats:sub>\n                    AChR and M\n                    <jats:sub>3<\/jats:sub>\n                    AChR.\n                  <\/jats:p>","DOI":"10.1515\/znc-2020-0153","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T20:21:05Z","timestamp":1618863665000},"page":"383-391","source":"Crossref","is-referenced-by-count":2,"title":["Comparative spasmolytic effect between\n                    <i>Cinnamomum tamala<\/i>\n                    and\n                    <i>Cinnamomum verum<\/i>\n                    leaf essential oils and eugenol through\n                    <i>in vitro<\/i>\n                    and\n                    <i>in silico<\/i>\n                    approaches"],"prefix":"10.1515","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3951-4469","authenticated-orcid":false,"given":"Anubhav","family":"Chakraborty","sequence":"first","affiliation":[{"name":"School of Chemical and Biotechnology , SASTRA Deemed University , Thanjavur , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwam","family":"Sankaran","sequence":"additional","affiliation":[{"name":"School of Chemical and Biotechnology , SASTRA Deemed University , Thanjavur , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9329-8245","authenticated-orcid":false,"given":"Ramar","family":"Murugan","sequence":"additional","affiliation":[{"name":"Centre for Research and Postgraduate Studies in Botany, Ayya Nadar Janaki Ammal College (Autonomous) , Sivakasi , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-2595","authenticated-orcid":false,"given":"David Raj","family":"Chellappan","sequence":"additional","affiliation":[{"name":"Central Animal Facility , School of Chemical and Biotechnology, SASTRA Deemed University , Thanjavur , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"2023040103102755020_j_znc-2020-0153_ref_001","unstructured":"Kostermans, AJGH. 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