{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T09:04:50Z","timestamp":1782032690753,"version":"3.54.5"},"reference-count":60,"publisher":"Walter de Gruyter GmbH","issue":"9-10","funder":[{"name":"Karadeniz Technical University Scientific Research Projects Unit","award":["THD-2018-7353"],"award-info":[{"award-number":["THD-2018-7353"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study is to determine the potent biological activities and carry out isolation studies on<jats:italic>Barbarea integrifolia<\/jats:italic>. The antioxidant capacity of the species was evaluated by total phenolic content, FRAP, CUPRAC, and DPPH radical scavenging activity. Anticancer activity studies were performed by MTT assay in MDA-MB-231, MCF-7, Hep3B, PC-3, A549, HCT116, L-929\u00a0cell lines. It was observed that the remaining aqueous fraction has higher total phenolic content while higher activity in the CUPRAC and FRAP assays was displayed for the methanolic extract and chloroform fraction. The extracts showed anticancer activity as compared with vincristine. It was observed that chloroform fraction has the highest anticancer activity on MCF-7\u00a0cell line, while ethyl acetate fraction has the highest anticancer activity on Hep-3B and A549\u00a0cell lines. Methanolic extract has the highest anticancer activity on HCT116 and MDA-MB-23\u00a0cell lines. The isolation studies have been performed using several chromatographic methods. The chemical structures of compounds have been identified by means of<jats:sup>1<\/jats:sup>H NMR,<jats:sup>13<\/jats:sup>C NMR, 2D-NMR, and MS. Five major compounds, one steroid (<jats:italic>\u03b2<\/jats:italic>-Sitosterol), one phenolic acid (Rosmarinic acid), one flavonol heteroside (kaempferol 7-<jats:italic>O<\/jats:italic>-<jats:italic>\u03b1<\/jats:italic>-<jats:sc>l<\/jats:sc>-rhamnoside-3-<jats:italic>O<\/jats:italic>-<jats:italic>\u03b2<\/jats:italic>-<jats:sc>d<\/jats:sc>-(2-<jats:italic>O<\/jats:italic>-<jats:italic>\u03b2<\/jats:italic>-<jats:sc><jats:italic>d<\/jats:italic><\/jats:sc>-glucosyl)-<jats:italic>\u03b2<\/jats:italic>-<jats:sc>d<\/jats:sc>-glucoside), and two glucosinolates (Gluconasturtiin, Gluconasturtiin choline salt) have been isolated.<\/jats:p>","DOI":"10.1515\/znc-2020-0305","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T22:55:16Z","timestamp":1617836116000},"page":"375-382","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of biological activities of<i>Barbarea integrifolia<\/i>and isolation of a new glucosinolate derivated compound"],"prefix":"10.1515","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1265-5616","authenticated-orcid":false,"given":"Merve","family":"Badem","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy , Karadeniz Technical University , 61080 Trabzon , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0131la Ozlem","family":"Sener","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy , Karadeniz Technical University , 61080 Trabzon , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyda","family":"Kanbolat","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy , Karadeniz Technical University , 61080 Trabzon , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuriye","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy , Karadeniz Technical University , 61080 Trabzon , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sermet","family":"Yildirmi\u015f","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy , Karadeniz Technical University , 61080 Trabzon , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Ozgen","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy , Karadeniz Technical University , 61080 Trabzon , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rezzan","family":"Aliyazicioglu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy , Karadeniz Technical University , 61080 Trabzon , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Salva","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy , \u0130n\u00f6n\u00fc University , 44280 Malatya , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fcbra","family":"Kaban","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy , \u0130n\u00f6n\u00fc University , 44280 Malatya , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Arts and Sciences , Erzincan University , 24000 Erzincan , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5489-3420","authenticated-orcid":false,"given":"\u0130hsan","family":"Cal\u0131s","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy , Near East University , 99138 Nicosia , N Cyprus , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"2023040103102752110_j_znc-2020-0305_ref_001","unstructured":"Baytop, T. 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