{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:54:23Z","timestamp":1792122863554,"version":"4.4.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"3-4","funder":[{"DOI":"10.13039\/501100005920","name":"Organisation for Women in Science for the Developing World","doi-asserted-by":"publisher","award":["3240287314"],"award-info":[{"award-number":["3240287314"]}],"id":[{"id":"10.13039\/501100005920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001333","name":"Rhodes University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"German Academic Exchange Service","doi-asserted-by":"publisher","award":["57316173"],"award-info":[{"award-number":["57316173"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The antiplasmodium assay-guided investigation of the roots, stem bark, and leaves of <jats:italic>Persea americana<\/jats:italic> Mill. led to the isolation of a new fatty alcohol, perseatriol (<jats:bold>1<\/jats:bold>), along with six known compounds (<jats:bold>2\u20137<\/jats:bold>). Their structures were elucidated based on the analysis of their NMR and MS data. All crude extracts and fractions exhibited good antiplasmodial activity on <jats:italic>Plasmoduim falciparum<\/jats:italic> 3D7 with IC<jats:sub>50<\/jats:sub> values ranging from 0.76 to 10.5\u00a0\u03bcg\/mL; they also displayed cytotoxicity against HeLa cells with low selectivity indexes (SIs). A preliminary <jats:italic>Plasmodium<\/jats:italic> lactate dehydrogenase (pLDH) assay was also performed on the isolated compounds. 9,9\u2032-Di-<jats:italic>O<\/jats:italic>-feruloyl-5,5\u2032-dimethoxysecoisolariciresinol (<jats:bold>4<\/jats:bold>) turned out to be non-toxic and displayed the best activities on <jats:italic>P.\u00a0falciparum<\/jats:italic> with an IC<jats:sub>50<\/jats:sub> value of 0.05\u00a0\u03bcM, comparable to the reference drug chloroquine with an IC<jats:sub>50<\/jats:sub> value of 0.03\u00a0\u03bcM. Furthermore, besides compound <jats:bold>4<\/jats:bold>, this work reports the first isolation of lutein (<jats:bold>2<\/jats:bold>) and scopoletin (<jats:bold>3<\/jats:bold>) from <jats:italic>P.\u00a0americana<\/jats:italic>. The crude extracts of roots, stem bark, and leaves of <jats:italic>P.\u00a0americana<\/jats:italic>, their fractions and compounds completely suppressed the growth of <jats:italic>P.\u00a0falciparum<\/jats:italic>. The observed activity supports the use of <jats:italic>P.\u00a0americana<\/jats:italic> in folk medicine for the treatment of malaria.<\/jats:p>","DOI":"10.1515\/znc-2021-0182","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T13:56:21Z","timestamp":1637157381000},"page":"125-131","source":"Crossref","is-referenced-by-count":1,"title":["Bioguided isolation of antiplasmodial secondary metabolites from <i>Persea americana<\/i> Mill. (Lauraceae)"],"prefix":"10.1515","volume":"77","author":[{"given":"Christine Claire","family":"Waleguele","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry , Faculty of Science, University of Yaound\u00e9 I , P.O. Box\u00a0812 , Yaound\u00e9 , Cameroon"},{"name":"Department of Chemistry , Rhodes University , P.O. Box\u00a094 , Grahamstown\/Makhanda 6140 , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marthe Aim\u00e9e","family":"Tchuente Tchuenmogne","sequence":"additional","affiliation":[{"name":"Department of Chemistry , Faculty of Science, University of Dschang , P.O. Box\u00a067 , Dschang , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick St\u00e9phane","family":"Fotsing Fongang","sequence":"additional","affiliation":[{"name":"Department of Chemistry , Higher Teachers\u2019 Training College, University of Maroua , P.O. Box\u00a055 , Maroua , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules","family":"Ngatchou","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry , Faculty of Science, University of Yaound\u00e9 I , P.O. Box\u00a0812 , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8483-6080","authenticated-orcid":false,"given":"Jean Jules","family":"Kezetas Bankeu","sequence":"additional","affiliation":[{"name":"Department of Chemistry , Faculty of Science, The University of Bamenda , P.O. Box\u00a039 , Bambili , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustin Silv\u00e8re","family":"Ngouela","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry , Faculty of Science, University of Yaound\u00e9 I , P.O. Box\u00a0812 , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Tsamo","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry , Faculty of Science, University of Yaound\u00e9 I , P.O. Box\u00a0812 , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0309-2655","authenticated-orcid":false,"given":"Norbert","family":"Sewald","sequence":"additional","affiliation":[{"name":"Department of Chemistry , Bielefeld University , P.O. Box\u00a0100131, 33501 Bielefeld , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-6449","authenticated-orcid":false,"given":"Rui Werner Ma\u00e7edo","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Chemistry , Rhodes University , P.O. Box\u00a094 , Grahamstown\/Makhanda 6140 , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Ndjakou","family":"Lenta","sequence":"additional","affiliation":[{"name":"Department of Chemistry , Higher Teacher Training College, University of Yaound\u00e9 I , P.O. Box\u00a047 , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"2023040103431255374_j_znc-2021-0182_ref_001","unstructured":"WHO. 2018. World malaria report."},{"key":"2023040103431255374_j_znc-2021-0182_ref_002","doi-asserted-by":"crossref","unstructured":"Kumar, A, Paliwal, D, Saini, D, Thakur, A, Aggarwal, S, Kaushik, D. A comprehensive review on synthetic approach for antimalarial agents. 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