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In this study, we evaluated the ability of ten 1,2,3-triazole derivatives AM001 to AM010 to inhibit pertinent\n                    <jats:italic>in vitro<\/jats:italic>\n                    (coagulant, hemolytic, and proteolytic) and\n                    <jats:italic>in vivo<\/jats:italic>\n                    (hemorrhagic, edematogenic, and lethal) activities of\n                    <jats:italic>Bothrops jararaca<\/jats:italic>\n                    venom. The derivatives were synthesized, and had their molecular structures fully characterized by CHN element analysis, Fourier-transform infrared spectroscopy and Nuclear magnetic resonance. The derivatives were incubated with the\u00a0\n                    <jats:italic>B.\u00a0jararaca<\/jats:italic>\n                    venom (incubation protocol) or administered before (prevention protocol) or after (treatment protocol) the injection of\n                    <jats:italic>B.\u00a0jararaca<\/jats:italic>\n                    venom into the animals. Briefly, the derivatives were able to inhibit the main toxic effects triggered by\n                    <jats:italic>B.\u00a0jararaca<\/jats:italic>\n                    venom, though with varying efficacies, and they were devoid of toxicity through\n                    <jats:italic>in vivo<\/jats:italic>\n                    ,\n                    <jats:italic>in silico<\/jats:italic>\n                    or\n                    <jats:italic>in vitro<\/jats:italic>\n                    analyses. However, it seemed that the derivatives AM006 or AM010 inhibited more efficiently hemorrhage or lethality, respectively. The derivatives were nontoxic. Therefore, the 1,2,3-triazole derivatives may be useful as an adjuvant to more efficiently treat the local toxic effects caused by\n                    <jats:italic>B.\u00a0jararaca<\/jats:italic>\n                    envenoming.\n                  <\/jats:p>","DOI":"10.1515\/znc-2022-0010","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T16:35:01Z","timestamp":1656434101000},"page":"459-471","source":"Crossref","is-referenced-by-count":3,"title":["Study on the synthesis and structure-activity relationship of 1,2,3-triazoles against toxic activities of\n                    <i>Bothrops jararaca<\/i>\n                    venom"],"prefix":"10.1515","volume":"77","author":[{"given":"Jenifer Frouche","family":"de Souza","sequence":"first","affiliation":[{"name":"Post-Graduate Program in Science and Biotechnology, Institute of Biology, Federal Fluminense University , Niter\u00f3i , RJ , Brazil"},{"name":"Department of Molecular and Cellular Biology , Federal Fluminense University , Niter\u00f3i , RJ , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Vinicius da Silva","family":"Santana","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Science and Biotechnology, Institute of Biology, Federal Fluminense University , Niter\u00f3i , RJ , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cl\u00e1udia Rodrigues","family":"da Silva","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Science and Biotechnology, Institute of Biology, Federal Fluminense University , Niter\u00f3i , RJ , Brazil"},{"name":"Department of Molecular and Cellular Biology , Federal Fluminense University , Niter\u00f3i , RJ , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio Roberto Henriques","family":"Donza","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry , Institute of Chemistry, Federal University of Rio de Janeiro , RJ , RJ , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Francisco","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology , Faculty of Pharmacy, Federal Fluminense University , Niter\u00f3i , RJ , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Baptista","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry , Institute of Chemistry, Federal University of Rio de Janeiro , RJ , RJ , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eladio Flores","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry of Proteins from Animal Venoms, Research and Development Center , Ezequiel Dias Foundation , Belo Horizonte , MG , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Carla","family":"Castro","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Science and Biotechnology, Institute of Biology, Federal Fluminense University , Niter\u00f3i , RJ , Brazil"},{"name":"Department of Molecular and Cellular Biology , Federal Fluminense University , Niter\u00f3i , RJ , Brazil"},{"name":"Post-Graduate Program in Pathology, University Hospital Ant\u00f4nio Pedro, Federal Fluminense University , Niter\u00f3i , RJ , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Lopes","family":"Fuly","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Science and Biotechnology, Institute of Biology, Federal Fluminense University , Niter\u00f3i , RJ , Brazil"},{"name":"Department of Molecular and Cellular Biology , Federal Fluminense University , Niter\u00f3i , RJ , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"2023040103104608297_j_znc-2022-0010_ref_001","unstructured":"WHO. 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