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Structures of these new spiro derivatives were deduced from HRMS and NMR spectral data. A plausible mechanism for the observed thermodynamic control pathway is presented herewith. Interestingly, the spiro adduct, derived from 5-chloro-1-methylisatin, exhibited excellent antiproliferative activity on MCF7, A549 and Hela human cell lines (IC<jats:sub>50<\/jats:sub>\u00a0\u2243\u00a07\u00a0\u03bcM).<\/jats:p>","DOI":"10.1515\/znc-2022-0085","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:38:34Z","timestamp":1676594314000},"page":"141-148","source":"Crossref","is-referenced-by-count":11,"title":["Thermodynamic control synthesis of spiro[oxindole-3,3\u2032-pyrrolines] <i>via<\/i> 1,4-dipolar cycloaddition utilizing imidazo[1,5-<i>a<\/i>]quinoline"],"prefix":"10.1515","volume":"78","author":[{"given":"Areej M.","family":"Jaber","sequence":"first","affiliation":[{"name":"Chemistry Department , Faculty of Science , The University of Jordan , Amman 11942 , Jordan"},{"name":"Pharmacological and Diagnostic Research Center, Faculty of Pharmacy , Al-Ahliyya Amman University , Amman 19328 , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6768-7183","authenticated-orcid":false,"given":"Jalal A.","family":"Zahra","sequence":"additional","affiliation":[{"name":"Chemistry Department , Faculty of Science , The University of Jordan , Amman 11942 , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2663-3677","authenticated-orcid":false,"given":"Mustafa M.","family":"El-Abadelah","sequence":"additional","affiliation":[{"name":"Chemistry Department , Faculty of Science , The University of Jordan , Amman 11942 , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim S.","family":"Sabri","sequence":"additional","affiliation":[{"name":"Chemistry Department , Faculty of Science , The University of Jordan , Amman 11942 , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dua\u2019a S.","family":"Sabbah","sequence":"additional","affiliation":[{"name":"University of Petra Pharmaceutical Center (UPPC), University of Petra , Amman 11196 , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"2023040103535327651_j_znc-2022-0085_ref_001","doi-asserted-by":"crossref","unstructured":"Younus, HA, Al-Rashida, M, Hameed, A, Uroos, M, Salar, U, Rana, S, et al.. 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