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Nitro group reduction of the latter resulted in the corresponding 8-aminoquinolone-3-esters which upon hydrolysis formed the respective 8-amino-7-(aryl\/hetaryl)-quinolone-3-carboxylic acids. The latter compounds were tested against selected Gram-negative bacteria (<jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Salmonella typhimurium<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, <jats:italic>Acinetobacter baumannii<\/jats:italic>, and <jats:italic>Klebsiella pneumonia<\/jats:italic>) and Gram-positive bacteria (<jats:italic>Enterococcus feacalis<\/jats:italic>, <jats:italic>Listeria monocytogenes<\/jats:italic>, <jats:italic>Streptococcus agalactiae<\/jats:italic>, <jats:italic>Staphylococcus epidermidis<\/jats:italic>, and <jats:italic>Staphylococcus aureus<\/jats:italic>). The tested fluoroquinolones showed a significant antimicrobial activity against most of the tested bacterial strains. The antimicrobial activity of some of the tested compounds were comparable to or higher than a wide range of standard antibiotics including ampicillin, ciprofloxacin, and imipenem. The results highlight the new synthesized 8-amino-7-(aryl\/hetaryl)fluroquinolones as promising candidates for new antimicrobial drugs to treat bacterial infections. This study highlights that the newly synthetic 8-amino-7-(aryl\/hetaryl)fluroquinolones are promising candidates for new antimicrobial drugs to treat human diseases including foodborne illnesses.<\/jats:p>","DOI":"10.1515\/znc-2022-0143","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T07:11:36Z","timestamp":1666336296000},"page":"157-168","source":"Crossref","is-referenced-by-count":1,"title":["8-Amino-7-(aryl\/hetaryl)fluoroquinolones. An emerging set of synthetic antibacterial agents"],"prefix":"10.1515","volume":"78","author":[{"given":"Ala\u2019a A.","family":"Al-Akhras","sequence":"first","affiliation":[{"name":"Chemistry Department , Faculty of Science, The University of Jordan , Amman , 11942 , Jordan"},{"name":"Chemistry Department , Faculty of Science, Jerash University , Jerash , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalal A.","family":"Zahra","sequence":"additional","affiliation":[{"name":"Chemistry Department , Faculty of Science, The University of Jordan , Amman , 11942 , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa M.","family":"El-Abadelah","sequence":"additional","affiliation":[{"name":"Chemistry Department , Faculty of Science, The University of Jordan , Amman , 11942 , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubna F.","family":"Abu-Niaaj","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Life Sciences , College of Engineering, Science, Technology and Agriculture, Central State University , Wilberforce , OH 45384 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monther A.","family":"Khanfar","sequence":"additional","affiliation":[{"name":"Chemistry Department , Faculty of Science, The University of Jordan , Amman , 11942 , Jordan"},{"name":"Department of Chemistry , Pure and Applied Chemistry Group, College of Sciences, University of Sharjah , Sharjah 27272 , UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"2023040103535311617_j_znc-2022-0143_ref_001","doi-asserted-by":"crossref","unstructured":"Yanshu, JA, Liyan, Z. 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