{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:58:34Z","timestamp":1777384714595,"version":"3.51.4"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"5-6","funder":[{"name":"Wallaga University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Teclea nobilis<\/jats:italic>is a medicinal plant widely used to treat oral pathogens, gonorrhea, fever, analgesics, asthma, joint pains, pneumonia, and intestinal worms in Ethiopia. Anticipated by these claims, column chromatographic separation of the roots extract of<jats:italic>T<\/jats:italic>.<jats:italic>nobilis<\/jats:italic>led to the isolation of eight alkaloids (1\u20138). The structures of the isolated compounds were identified based on their NMR (1D and 2D) spectral data analysis and comparison with reported literature data.<jats:italic>In-silico<\/jats:italic>molecular docking analysis of the isolated compounds were performed against<jats:italic>Staphylococcus aureus<\/jats:italic>DNA Gyrase (PDB ID: 2XCT) and human topoisomerase II\u03b2 DNA (PDB ID: 3QX3) by using AutoDock Vina. ADMET analysis were performed by SwissADME, PreADMET, and OSIRIS Property predictions. The study revealed that the isolated compounds exhibited promising binding affinity to\u00a0DNA gyrase, especially with compound 5 forms a stable drug-protein complex. Whereas the ADME and drug-likeness analysis revealed that compound 5 is less absorbed from the gastrointestinal tract, crossblood brain barrier and a P-glycoprotein substrate. This indicated that compound 5 could be a good candidate as anticancer agent provided that<jats:italic>in vivo<\/jats:italic>analysis done for more confirmation.<\/jats:p>","DOI":"10.1515\/znc-2022-0154","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T12:26:12Z","timestamp":1668169572000},"page":"217-227","source":"Crossref","is-referenced-by-count":3,"title":["Furoquinoline and bisindole alkaloids from the roots of<i>Teclea nobilis<\/i>and their<i>in-silico<\/i>molecular docking analysis"],"prefix":"10.1515","volume":"78","author":[{"given":"Tamrat Tesfaye","family":"Ayele","sequence":"first","affiliation":[{"name":"Department of Chemistry , College of Natural and Computational Sciences, Wallaga University , Nekemte , Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Getahun Tadesse","family":"Gurmessa","sequence":"additional","affiliation":[{"name":"Department of Chemistry , College of Natural and Computational Sciences, Wallaga University , Nekemte , Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zelalem","family":"Abdissa","sequence":"additional","affiliation":[{"name":"Department of Chemistry , College of Natural and Computational Sciences, Wallaga University , Nekemte , Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadessa","family":"Melaku","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry , School of Applied Natural Science, Adama Science and Technology University , Adama , Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankita","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry , School of Applied Natural Science, Adama Science and Technology University , Adama , Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kibrom Gebreheiwot","family":"Bedane","sequence":"additional","affiliation":[{"name":"Department of Chemistry , College of Computational and Natural Sciences, Addis Ababa University , Addis Ababa , Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negera","family":"Abdissa","sequence":"additional","affiliation":[{"name":"Department of Chemistry , College of Natural and Computational Sciences, Wallaga University , Nekemte , Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"2023042812204072764_j_znc-2022-0154_ref_001","doi-asserted-by":"crossref","unstructured":"Patra, JK, Das, G, Fraceto, LF, Campos, EVR, Rodriguez-Torres, MDP, Torres, LSA, et al.. 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