{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:58:35Z","timestamp":1776329915980,"version":"3.50.1"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"11-12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chemical investigation of the fungal endophyte <jats:italic>Xylaria<\/jats:italic> sp. isolated from leaves of <jats:italic>Moringa oleifera<\/jats:italic>, collected in Cameroon, resulted in the previously undescribed 10-membered macrolide, and two known natural\u00a0products. The structures of the xylatolides A and B were unambiguously identified by their mass spectra and by extensive 1D and 2D NMR spectroscopic analysis, featuring a 10-membered lactone core structure with oxygenated substituents and an unsubstituted 10-alkyl chain presenting seven carbon atoms. Compounds were screened for their cytotoxic potential against the human HepG2 hepatocellular carcinoma cells and HCT-116 cells (human colon carcinoma cell line). Moreover, the isolated compounds were also assayed against a small panel of\u00a0sensitive strains including the bacterial species <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Staphylococcus aureus<\/jats:italic>, and <jats:italic>Mycobacterium tuberculosis<\/jats:italic> as well as against the fungal species <jats:italic>Candida albicans<\/jats:italic>. However, no significant activities were found.<\/jats:p>","DOI":"10.1515\/znc-2023-0091","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T09:21:18Z","timestamp":1719480078000},"page":"371-376","source":"Crossref","is-referenced-by-count":4,"title":["Xylatolides A and B, new 10-membered macrolides from the endophytic fungus <i>Xylaria<\/i> sp."],"prefix":"10.1515","volume":"79","author":[{"given":"Pierre Roger","family":"Koliye","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences , 231173 University of Douala , P.O. Box\u00a024157 Douala , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille","family":"Nouga Bissoue","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences , 231173 University of Douala , P.O. Box\u00a024157 Douala , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eitel","family":"Ngoh Misse Mouelle","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences , 231173 University of Douala , P.O. Box\u00a024157 Douala , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Kwanga Nguikwie","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Sciences , 231173 University of Douala , P.O. Box\u00a024157 Douala , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudine Victoire","family":"Zambo Owona","sequence":"additional","affiliation":[{"name":"Process Engineering Laboratory, Advanced Teachers\u2019 Training College for Technical Education , 231173 University of Douala , P.O. Box\u00a01872 Douala , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor Emanuel","family":"Simons","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Biology and Biotechnology , Heinrich Heine University , D\u00fcsseldorf , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergi Herve","family":"Akone","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences , 231173 University of Douala , P.O. Box\u00a024157 Douala , Cameroon"},{"name":"Department of Microbial Natural Products (MINS), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS) , University of Saarland , D-66123 Saarbr\u00fccken , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Mbaze Meva\u2019a","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences , 231173 University of Douala , P.O. 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