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This study investigated the anti-inflammatory effects of homalolide A (<jats:bold>1<\/jats:bold>) and homalomenol A (<jats:bold>2<\/jats:bold>), two sesquiterpenoids isolated from the rhizome of <jats:italic>Homalomena pendula<\/jats:italic>, on lipopolysaccharide (LPS)- stimulated macrophage cells. The results demonstrated that both <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> dose-dependently inhibited the production of PGE<jats:sub>2<\/jats:sub>, TNF-\u03b1 and IL-6 in RAW 264.7 macrophages. Furthermore, <jats:bold>2<\/jats:bold> also stimulated IL-10 production in RAW 264.7\u202fcells. Consistent with these findings, these compounds suppressed the LPS-stimulated protein levels of iNOS and COX-2 in RAW 264.7\u202fcells. These results suggested that <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> could be effective candidates for ameliorating inflammatory-associated complications.<\/jats:p>","DOI":"10.1515\/znc-2024-0152","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T20:12:52Z","timestamp":1732133572000},"page":"353-359","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of pro-inflammatory cytokines by homalolide A and homalomenol A isolated from rhizomes of <i>Homalomena pendula<\/i>"],"prefix":"10.1515","volume":"80","author":[{"given":"Linh Thuy","family":"Khanh Nguyen","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy , Hue University of Medicine and Pharmacy, Hue University , 06 Ngo Quyen , Hue City , Vietnam"},{"name":"Faculty of Pharmacy , University of Medicine and Pharmacy at Ho Chi Minh City , 217 Hong Bang , Ho Chi Minh , Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hien Bich","family":"Thi Le","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy , Hue University of Medicine and Pharmacy, Hue University , 06 Ngo Quyen , Hue City , Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi","family":"Van Anh Tran","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy , University of Medicine and Pharmacy at Ho Chi Minh City , 217 Hong Bang , Ho Chi Minh , Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoai Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy , Hue University of Medicine and Pharmacy, Hue University , 06 Ngo Quyen , Hue City , Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7442-3925","authenticated-orcid":false,"given":"Duc Viet","family":"Ho","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy , Hue University of Medicine and Pharmacy, Hue University , 06 Ngo Quyen , Hue City , Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1451-3769","authenticated-orcid":false,"given":"Hien Minh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy , Ton Duc Thang University , Ho Chi Minh City , Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"2025070311085664342_j_znc-2024-0152_ref_001","doi-asserted-by":"crossref","unstructured":"Sacca, R, Cuff, CA, Ruddle, NH. 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