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The crystal structure of compound\n                    <jats:bold>1d<\/jats:bold>\n                    was obtained by single-crystal X-ray crystallography. They were found to have inhibitory effects on the anticancer potentials and human carbonic anhydrase isoforms I and II. Compound\n                    <jats:bold>1d<\/jats:bold>\n                    was found to be the strongest inhibitor, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.133\u202f\u00b5M against hCA I. Also, compound\n                    <jats:bold>1l<\/jats:bold>\n                    showed the highest inhibitory activity with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 3.244\u202f\u00b5M against hCA II. Moreover, their cytotoxic effects on rat glioma cell and colon adeno carcinoma cell lines were evaluated. According to the cytotoxicity results, compounds\n                    <jats:bold>1j<\/jats:bold>\n                    and\n                    <jats:bold>1l<\/jats:bold>\n                    exhibited the highest cytotoxicity on the HT29 cell, while compounds\n                    <jats:bold>1e<\/jats:bold>\n                    ,\n                    <jats:bold>1g,<\/jats:bold>\n                    and\n                    <jats:bold>1l<\/jats:bold>\n                    showed the strongest cytotoxic effect on C6 cell line. Compound\n                    <jats:bold>1l<\/jats:bold>\n                    , which carries the methoxy substituent at the 3\n                    <jats:sup>rd<\/jats:sup>\n                    position on the phenyl ring, was effective against both cancer cells and showed the highest inhibitory effect on hCA II. The ADME\/T properties and molecular docking of the molecules with the highest activity were examined.\n                  <\/jats:p>","DOI":"10.1515\/znc-2024-0226","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T08:46:15Z","timestamp":1741855575000},"page":"705-718","source":"Crossref","is-referenced-by-count":6,"title":["New hydrazone derivatives: synthesis, characterization, carbonic anhydrase I-II enzyme inhibition, anticancer activity and\n                    <i>in silico<\/i>\n                    studies"],"prefix":"10.1515","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-1034","authenticated-orcid":false,"given":"Ulviye","family":"Acar Cevik","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy , 52944 Anadolu University , Eski\u015fehir 26470 , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"\u00dcnver","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science , Eskisehir Technical University , Eskisehir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrani Eren","family":"Bostanc\u0131","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy , Cumhuriyet University , Sivas , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"T\u00fcz\u00fcn","sequence":"additional","affiliation":[{"name":"Plant and Animal Production Department, Technical Sciences Vocational School of Sivas , Sivas Cumhuriyet University , Sivas , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurten \u0130rem","family":"Gedik","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy , Cumhuriyet University , Sivas , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dcmit M.","family":"Kocyigit","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy , Cumhuriyet University , Sivas , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"2025110310023707472_j_znc-2024-0226_ref_001","doi-asserted-by":"crossref","unstructured":"Angeli, A, Kartsev, V, Petrou, A, Lichitsky, B, Komogortsev, A, Pinteala, M, et al.. 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