{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:39:29Z","timestamp":1788367169354,"version":"build-2803163510"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"11-12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study assessed the\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    antibacterial and antibiofilm properties of new 1,3,4-thiadiazole derivatives.\n                    <jats:sup>1<\/jats:sup>\n                    H NMR and\n                    <jats:sup>13<\/jats:sup>\n                    C NMR analyses were employed to confirm the structure of the synthesized compounds, the characterization is followed by assessments of their efficacy against\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    NRRL B478,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ATCC 29213,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ATCC 25922,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ATCC 27853, as well as for antifungal activity against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    ATCC 90028 and\n                    <jats:italic>Candida krusei<\/jats:italic>\n                    ATCC 6258, using the broth microdilution method. Notably, among the tested compounds, compound\n                    <jats:bold>4a<\/jats:bold>\n                    exhibited the highest antimicrobial activity, with a minimal inhibitory concentration of 125\u202f\u03bcg\/mL against\n                    <jats:italic>P.\u00a0aeruginosa<\/jats:italic>\n                    ATCC 27853 and significant antibiofilm activity, achieving 94\u202f%, 98\u202f% and 100\u202f% biofilm inhibition at 250, 500 and 1,000\u202f\u03bcg\/mL, respectively. Besides, compound\n                    <jats:bold>4h<\/jats:bold>\n                    achieved 81\u202f%, 89\u202f% and 98\u202f%\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    ATCC 29213 biofilm inhibition at 250, 500 and 1,000\u202f\u03bcg\/mL, respectively, and displayed potent antibacterial activity against this bacterium. Finally, the theoretical ADME properties of the compounds\n                    <jats:bold>4a<\/jats:bold>\n                    -\n                    <jats:bold>4h<\/jats:bold>\n                    were analyzed by calculations. This study has consolidated a base for the development of new antibacterial and antibiofilm agents and advanced our understanding of their potential mode of action against biofilm-associated infections.\n                  <\/jats:p>","DOI":"10.1515\/znc-2024-0294","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T12:10:50Z","timestamp":1740744650000},"page":"719-726","source":"Crossref","is-referenced-by-count":2,"title":["Design and synthesis of new 1,3,4-thiadiazoles as antimicrobial and antibiofilm agents"],"prefix":"10.1515","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1713-9485","authenticated-orcid":false,"given":"Bet\u00fcl","family":"Kaya","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy , 53001 Bulent Ecevit University , Zonguldak , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-1034","authenticated-orcid":false,"given":"Ulviye","family":"Acar \u00c7evik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy , 52944 Anadolu University , Eski\u015fehir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pervin","family":"Soyer","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Faculty of Pharmacy , Anadolu University , Eski\u015fehir , 26470 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Taha","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Hamidiye Faculty of Health Sciences , University of Health Sciences , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"\u00d6zkay","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy , 52944 Anadolu University , Eski\u015fehir , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafer As\u0131m","family":"Kaplanc\u0131kl\u0131","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy , 52944 Anadolu University , Eski\u015fehir , T\u00fcrkiye"},{"name":"The Rectorate of Bilecik \u015eeyh Edebali University , 11230 , Bilecik , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"2025110310023743532_j_znc-2024-0294_ref_001","doi-asserted-by":"crossref","unstructured":"Glomb, T, \u015awi\u0105tek, P. 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