{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T20:29:57Z","timestamp":1781987397761,"version":"3.54.5"},"reference-count":101,"publisher":"Walter de Gruyter GmbH","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Medicinal plants have long been used as a primary healthcare resource for treating malaria and other diseases globally. Malaria, caused by\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    species, remains a serious health threat, with the World Health Organization reporting that over 40\u202f% of the global population lives in malaria-endemic regions. The rise of drug-resistant strains has further complicated treatment efforts, necessitating the search for new therapeutic agents. This review emphasizes the antimalarial potential of plant-derived secondary metabolites, which exhibit diverse pharmacological activities. Several compounds, such as ceramicine R (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a02.80\u202f\u03bcM), knipholone clooxanthrone (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a014.58\u202f\u03bcM for D6 and 9.42\u202f\u03bcM for W2), joziknipholone A (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a00.17\u202f\u03bcM), joziknipholone B (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a00.26\u202f\u03bcM), and cajachalcone (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a07.4\u202f\u03bcM), have shown potent activity against\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    . Data were collected from Web of Science, PubMed, Scopus, Google Scholar, and Science Direct. A total of 34 medicinal plants were identified, along with details on extraction techniques and factors influencing metabolite efficacy. Key secondary metabolites include alkaloids, flavonoids, terpenoids, and their derivatives (e.g., quinine, artemisinin, quercetin, chalcones). This review highlights their mechanisms of action and their promise as templates for developing novel drugs to combat both drug-sensitive and drug-resistant malaria strains.\n                  <\/jats:p>","DOI":"10.1515\/znc-2025-0037","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:19:58Z","timestamp":1758118798000},"page":"319-337","source":"Crossref","is-referenced-by-count":1,"title":["Plant-derived secondary metabolites for malaria treatment: extraction, mechanisms, and therapeutic potential"],"prefix":"10.1515","volume":"81","author":[{"given":"Addisu Tamir","family":"Wassie","sequence":"first","affiliation":[{"name":"Department of Industrial Chemistry , College of Natural and Applied Sciences, Addis Ababa Science and Technology University , P.O. Box: 16417 , Addis Ababa , Ethiopia"},{"name":"Department of Chemistry , College of Natural Sciences, Wollo University , P.O. Box: 1145 , Dessie , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Nasser","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry , College of Natural and Applied Sciences, Addis Ababa Science and Technology University , P.O. Box: 16417 , Addis Ababa , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-9027","authenticated-orcid":false,"given":"Rakesh Kumar","family":"Bachheti","sequence":"additional","affiliation":[{"name":"Center of Molecular Medicine and Diagnostics , Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University , Chennai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mesfin Getachew","family":"Tadesse","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry , College of Natural and Applied Sciences, Addis Ababa Science and Technology University , P.O. Box: 16417 , Addis Ababa , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aselefech Sorsa","family":"Wotango","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry , College of Natural and Applied Sciences, Addis Ababa Science and Technology University , P.O. Box: 16417 , Addis Ababa , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7728-6479","authenticated-orcid":false,"given":"Archana","family":"Bachheti","sequence":"additional","affiliation":[{"name":"Department of Environment Science , Graphic Era University , Dehradun , 248002 , Uttarakhand , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilma Hunde","family":"Gonfa","sequence":"additional","affiliation":[{"name":"Department of Chemistry , Ambo University , Ambo , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayalew Hussen","family":"Assen","sequence":"additional","affiliation":[{"name":"Department of Chemistry , College of Natural Sciences, Wollo University , P.O. 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