{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T18:15:36Z","timestamp":1778004936557,"version":"3.51.4"},"reference-count":71,"publisher":"Walter de Gruyter GmbH","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Oroxylum indicum<\/jats:italic>\n                    is an important Ayurvedic plant from the \u201cDasamoola\u201d group, traditionally used as a detoxifying agent. This study evaluates the protective effects of the root bark methanol extract of\n                    <jats:italic>O<\/jats:italic>\n                    .\n                    <jats:italic>indicum<\/jats:italic>\n                    (ORX) against acetaminophen-induced hepatotoxicity and cisplatin-induced nephrotoxicity in rats. The doses of ORX used in the study were selected based on the previous toxicity analysis (200\u202fmg\/kg and 400\u202fmg\/kg doses). Acetaminophen administration increased serum liver function markers (AST, ALT, ALP, bilirubin), while ORX and silymarin treatments significantly reduced these levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01). ORX administration also reversed the acetaminophen-induced depletion in hepatic redox balance as indicated in terms of SOD, GPx, GSH and lipid peroxidation. Corroborating these, the changes in the hepatic normal architecture induced by acetaminophen were also reversed by the pre-treatment with ORX. Similarly, the cisplatin administration resulted in strong myelosuppression and nephrotoxicity. In cisplatin-exposed rats, renal oxidative stress markers worsened, and serum renal function parameters were elevated. On the contrary, the pre-treatment with ORX alleviated the cisplatin-induced myelosuppression and redox imbalance in the renal tissues; further, it also restored the renal histology to near normal. Overall,\n                    <jats:italic>O<\/jats:italic>\n                    .\n                    <jats:italic>indicum<\/jats:italic>\n                    root bark extract effectively mitigated drug-induced liver and kidney damage, likely through redox balance restoration.\n                  <\/jats:p>","DOI":"10.1515\/znc-2025-0088","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T16:58:02Z","timestamp":1758733082000},"page":"429-440","source":"Crossref","is-referenced-by-count":0,"title":["<i>Oroxylum indicum<\/i>\n                    root bark extract mitigates hepato-renal damage induced by acetaminophen and cisplatin"],"prefix":"10.1515","volume":"81","author":[{"given":"Seema","family":"Menon","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Plant Biotechnology , Amala Cancer Research Centre , Amala Nagar , Thrissur , Kerala , India"},{"name":"Department of Zoology , Kodungallur Kunjikuttan Thampuran Memorial Government College (Affiliated to University of Calicut) , Pullut, Kodungallur , Thrissur , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lincy","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Plant Biotechnology , Amala Cancer Research Centre , Amala Nagar , Thrissur , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vipin P.","family":"Sivaram","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Plant Biotechnology , Amala Cancer Research Centre , Amala Nagar , Thrissur , Kerala , India"},{"name":"Department of Biochemistry , Government Arts and Science College, Kozhinjampara (Affiliated to University of Calicut) , Palakkad 678 554 , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Padikkala","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Plant Biotechnology , Amala Cancer Research Centre , Amala Nagar , Thrissur , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaji E.","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Plant Biotechnology , Amala Cancer Research Centre , Amala Nagar , Thrissur , Kerala , India"},{"name":"Department of Zoology , Kodungallur Kunjikuttan Thampuran Memorial Government College (Affiliated to University of Calicut) , Pullut, Kodungallur , Thrissur , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-1665","authenticated-orcid":false,"given":"Arunaksharan","family":"Narayanankutty","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Plant Biotechnology , Amala Cancer Research Centre , Amala Nagar , Thrissur , Kerala , India"},{"name":"Division of Cell and Molecular Biology, PG & Research Department of Zoology , St. Joseph\u2019s College (Autonomous), Devagiri, Affiliated to University of Calicut , Calicut - 673008 , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"2026050518051434108_j_znc-2025-0088_ref_001","doi-asserted-by":"crossref","unstructured":"Wei, S, Ma, W, Zhang, B, Li, W. 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