{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T19:00:22Z","timestamp":1780254022644,"version":"3.54.0"},"reference-count":61,"publisher":"Walter de Gruyter GmbH","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Boswellia neglecta<\/jats:italic>\n                    has been traditionally used to treat leukemia, cancer, and skin diseases. In this study, seven compounds (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>7<\/jats:bold>\n                    ) were isolated from the stem methanol extract and identified for the first time from this species using NMR spectroscopy. GC-MS analysis revealed\n                    <jats:bold>17<\/jats:bold>\n                    compounds, with olean-12-en-3-one (32.59\u202f%), oleic acid (13.79\u202f%), and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -amyrin (10.66\u202f%) as major constituents. Among the isolated compounds\n                    <jats:bold>7<\/jats:bold>\n                    showed the strongest antibacterial activity against\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    (MIC = 0.23 \u00b1 0.11\u202fmg\/mL). Compounds\n                    <jats:bold>3<\/jats:bold>\n                    \u2013\n                    <jats:bold>7<\/jats:bold>\n                    demonstrated promising antioxidant activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a01.29\u20137.05\u202f\u03bcg\/mL) compared with ascorbic acid (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a00.86\u202f\u03bcg\/mL). The methanol extract also exhibited significant cytotoxicity against MCF-7 breast cancer cells (27.25\u202f% viability at 200\u202f\u03bcg\/mL) and antiviral activity against influenza A (H1N1) (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a01.5\u202f\u03bcg\/mL, SI\u00a0=\u00a021). Molecular docking revealed that compound\n                    <jats:bold>7<\/jats:bold>\n                    had strong binding affinity against\n                    <jats:italic>P.\u00a0aeruginosa<\/jats:italic>\n                    DNA gyrase (\u221210.8\u202fkcal\/mol), surpassing ciprofloxacin (\u22126.9\u202fkcal\/mol). Compounds\n                    <jats:bold>3<\/jats:bold>\n                    \u2013\n                    <jats:bold>7<\/jats:bold>\n                    also had stronger affinities (\u22125.1 to\u00a0\u22126.5\u202fkcal\/mol) against human peroxiredoxin 5 and (\u22126.0 to\u00a0\u221210.3\u202fkcal\/mol) against myeloperoxidase compared to ascorbic acid (\u22124.7 and\u00a0\u22126.0\u202fkcal\/mol). These findings highlight the plant\u2019s therapeutic potential, warranting further\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    , preclinical, clinical, and mechanistic investigations.\n                  <\/jats:p>","DOI":"10.1515\/znc-2025-0094","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T15:14:53Z","timestamp":1758208493000},"page":"295-318","source":"Crossref","is-referenced-by-count":0,"title":["Integrated experimental and\n                    <i>In silico<\/i>\n                    evaluation of the antioxidant, antibacterial, antiviral, and antiproliferative activities of\n                    <i>Boswellia neglecta<\/i>\n                    S.\u00a0Moore stem extract and its bioactive constituents"],"prefix":"10.1515","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7758-6367","authenticated-orcid":false,"given":"Gashaw","family":"Nigussie","sequence":"first","affiliation":[{"name":"Traditional and Modern Medicine Research and Development Directorate , 70605 Armauer Hansen Research Institute , P.O.Box\u00a01005 , Addis Ababa , Ethiopia"},{"name":"Communicable and Non-Communicable Research Directorate , 70605 Armauer Hansen Research Institute , P.O.Box\u00a01005 , Addis Ababa , Ethiopia"},{"name":"Department of Applied Chemistry, College of Applied Natural Science , Adama Science and Technology University , P.O.Box 1888 , Adama , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Dekebo","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Applied Natural Science , Adama Science and Technology University , P.O.Box 1888 , Adama , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markos","family":"Abebe","sequence":"additional","affiliation":[{"name":"Communicable and Non-Communicable Research Directorate , 70605 Armauer Hansen Research Institute , P.O.Box\u00a01005 , Addis Ababa , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asfaw","family":"Meressa","sequence":"additional","affiliation":[{"name":"Traditional and Modern Medicine Research and Development Directorate , 70605 Armauer Hansen Research Institute , P.O.Box\u00a01005 , Addis Ababa , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temesgen","family":"Negassa","sequence":"additional","affiliation":[{"name":"Traditional and Modern Medicine Research and Development Directorate , 70605 Armauer Hansen Research Institute , P.O.Box\u00a01005 , Addis Ababa , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menberework","family":"Chanyalew","sequence":"additional","affiliation":[{"name":"Communicable and Non-Communicable Research Directorate , 70605 Armauer Hansen Research Institute , P.O.Box\u00a01005 , Addis Ababa , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Niukalova","sequence":"additional","affiliation":[{"name":"Virology Department , St. Petersburg Pasteur Institute , 14 Mira St. , St. Petersburg , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir V.","family":"Zarubaev","sequence":"additional","affiliation":[{"name":"Virology Department , St. Petersburg Pasteur Institute , 14 Mira St. , St. Petersburg , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiy","family":"Abebe","sequence":"additional","affiliation":[{"name":"Traditional and Modern Medicine Research and Development Directorate , 70605 Armauer Hansen Research Institute , P.O.Box\u00a01005 , Addis Ababa , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8331-2100","authenticated-orcid":false,"given":"Rajalakshmanan","family":"Eswaramoorthy","sequence":"additional","affiliation":[{"name":"Department of Biomaterials , Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University , Chennai , 600 077 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-9959","authenticated-orcid":false,"given":"Ahmed A.","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Chemistry , Cape Peninsula University of Technology, Bellville Campus , Bellville 7535 , Western Cape , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Hunsen","sequence":"additional","affiliation":[{"name":"Department of Chemistry , Kenyon College , Gambier , OH 43022 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-9923","authenticated-orcid":false,"given":"Milkyas","family":"Endale","sequence":"additional","affiliation":[{"name":"Traditional and Modern Medicine Research and Development Directorate , 70605 Armauer Hansen Research Institute , P.O.Box\u00a01005 , Addis Ababa , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"2026053118020539437_j_znc-2025-0094_ref_001","doi-asserted-by":"crossref","unstructured":"Dekebo, A, Dagne, E, Gautun, OR, Aasen, AJ. Triterpenes from the resin of Boswellia neglecta. Bull Chem Soc Ethiop 2002;16:87\u201390. https:\/\/doi.org\/10.4314\/bcse.v16i1.20952.","DOI":"10.4314\/bcse.v16i1.20952"},{"key":"2026053118020539437_j_znc-2025-0094_ref_002","doi-asserted-by":"crossref","unstructured":"Almeida-da-Silva, CLC, Sivakumar, N, Asadi, H, Chang-Chien, A, Qoronfleh, MW, Ojcius, DM, et al.. Effects of frankincense compounds\u00a0on infection, inflammation, and oral health. Molecules 2022;27:4174. https:\/\/doi.org\/10.3390\/molecules27134174.","DOI":"10.3390\/molecules27134174"},{"key":"2026053118020539437_j_znc-2025-0094_ref_003","doi-asserted-by":"crossref","unstructured":"Matata, DZ, Ngassapa, OD, Machumi, F, Moshi, MJ. Screening of plants used as traditional anticancer remedies in mkuranga and same districts, Tanzania, using brine shrimp toxicity bioassay. 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The frankincense tree Boswellia neglecta reveals high potential for restoration of woodlands in the Horn of Africa. For Ecol Manag 2017;385:16\u201324. https:\/\/doi.org\/10.1016\/j.foreco.2016.11.020.","DOI":"10.1016\/j.foreco.2016.11.020"},{"key":"2026053118020539437_j_znc-2025-0094_ref_007","doi-asserted-by":"crossref","unstructured":"Manguro, LOA, Wagai, SO, Onyango, JO. Terpenoids of Boswellia neglecta oleo-gum resin. Bull Chem Soc Ethiop 2016;30:317\u201323.","DOI":"10.4314\/bcse.v30i2.16"},{"key":"2026053118020539437_j_znc-2025-0094_ref_008","doi-asserted-by":"crossref","unstructured":"DeCarlo, A, Dosoky, NS, Satyal, P, Sorensen, A, Setzer, WN. The essential oils of the Burseraceae. In: Essential Oil Research: Trends in Biosynthesis, Analytics, Industrial Applications and Biotechnological Production. Cham: Springer; 2019:61\u2013145 pp.","DOI":"10.1007\/978-3-030-16546-8_4"},{"key":"2026053118020539437_j_znc-2025-0094_ref_009","doi-asserted-by":"crossref","unstructured":"Bekana, D, Kebede, T, Assefa, M, Kassa, H. Comparative phytochemical analyses of resins of boswellia species (B. Papyrifera (Del.) hochst., B.\u00a0neglecta S. Moore, and B.\u00a0rivae Engl.) from northwestern, southern, and southeastern Ethiopia. Int Sch Res Not 2014:374678. https:\/\/doi.org\/10.1155\/2014\/374678.","DOI":"10.1155\/2014\/374678"},{"key":"2026053118020539437_j_znc-2025-0094_ref_010","unstructured":"Hema, R, Kumaravel, S, Gomathi, S, Sivasubramaniam, C. Gas chromatography-mass spectroscopic analysis of Lawsonia inermis leaves. Life Sci J 2010;7:48\u201350."},{"key":"2026053118020539437_j_znc-2025-0094_ref_011","doi-asserted-by":"crossref","unstructured":"Abera, B, Melaku, Y, Shenkute, K, Degu, S, Abebe, A, Gemechu, W, et al.. 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ACS Omega 2024;9:31508\u201320. https:\/\/doi.org\/10.1021\/acsomega.4c01096.","DOI":"10.1021\/acsomega.4c01096"},{"key":"2026053118020539437_j_znc-2025-0094_ref_018","doi-asserted-by":"crossref","unstructured":"Yang, YR, Cho, JY, Park, YK. Isolation and identification of antioxidative compounds 3, 4-dihydroxybenzoic acid from black onion. Korean J.\u00a0Food Preserv. 2012;19:229\u201334. https:\/\/doi.org\/10.11002\/kjfp.2012.19.2.229.","DOI":"10.11002\/kjfp.2012.19.2.229"},{"key":"2026053118020539437_j_znc-2025-0094_ref_019","doi-asserted-by":"crossref","unstructured":"Abera, B, Melaku, Y, Shenkute, K, Dekebo, A, Abdissa, N, Endale, M, et al.. In vitro antibacterial, antioxidant, in\u00a0silico molecular docking and ADEMT analysis of chemical constituents from the roots of Acokanthera schimperi and Rhus glutinosa. Appl. Biol. Chem. 2024;67:77. https:\/\/doi.org\/10.1186\/s13765-024-00930-6.","DOI":"10.1186\/s13765-024-00930-6"},{"key":"2026053118020539437_j_znc-2025-0094_ref_020","unstructured":"Thu, NTX, Van Quang, N, Long, DD, Thuy, TTT. Structure and biological activity of five flavonoids from Ampelopsis cantoniensis. Vietnam J Sci Technol 2020;58:181\u20138."},{"key":"2026053118020539437_j_znc-2025-0094_ref_021","doi-asserted-by":"crossref","unstructured":"Lin, LC, Pai, YF, Tsai, TH. Isolation of luteolin and luteolin-7-O-glucoside from Dendranthema morifolium Ramat Tzvel and their pharmacokinetics in rats. J\u00a0Agric Food Chem 2015;63:7700\u20136. https:\/\/doi.org\/10.1021\/jf505848z.","DOI":"10.1021\/jf505848z"},{"key":"2026053118020539437_j_znc-2025-0094_ref_022","doi-asserted-by":"crossref","unstructured":"Tomimori, T, Miyaichi, Y, Imoto, Y, Kizu, H, Tanabe, Y. Studies on the constituents of scutellaria species. II. The flavonoid constituents of the roots of Scutellaria baicalensis georgi. Yakugaku Zasshi 1983;103:607\u201311. https:\/\/doi.org\/10.1248\/yakushi1947.103.6-607.","DOI":"10.1248\/yakushi1947.103.6_607"},{"key":"2026053118020539437_j_znc-2025-0094_ref_023","doi-asserted-by":"crossref","unstructured":"Similie, D, Minda, D, Bora, L, Kro\u0161kins, V, Lugi\u0146ina, J, Turks, M, et al.. An update on pentacyclic triterpenoids ursolic and oleanolic acids and related derivatives as anticancer candidates. Antioxidants 2024;13:952. https:\/\/doi.org\/10.3390\/antiox13080952.","DOI":"10.3390\/antiox13080952"},{"key":"2026053118020539437_j_znc-2025-0094_ref_024","doi-asserted-by":"crossref","unstructured":"Kim, JS, Kim, DK, Moon, JY, Lee, MY, Cho, SK. Oleic acid inhibits the migration and invasion of breast cancer cells with stemness characteristics through oxidative stress-mediated attenuation of the FAK\/AKT\/NF-\u03baB pathway. J\u00a0Funct Foods 2024;116:106224. https:\/\/doi.org\/10.1016\/j.jff.2024.106224.","DOI":"10.1016\/j.jff.2024.106224"},{"key":"2026053118020539437_j_znc-2025-0094_ref_025","doi-asserted-by":"crossref","unstructured":"Hashemi, FS, Farzadnia, F, Aghajani, A, Ahmadzadeh NobariAzar, F, Pezeshki, A. Conjugated linoleic acid loaded nanostructured lipid carrier as a potential antioxidant nanocarrier for food applications. Food Sci Nutr 2020;8:4185\u201395. https:\/\/doi.org\/10.1002\/fsn3.1712.","DOI":"10.1002\/fsn3.1712"},{"key":"2026053118020539437_j_znc-2025-0094_ref_026","doi-asserted-by":"crossref","unstructured":"Iorizzo, M, Di Martino, C, Letizia, F, Crawford, JTW, Paventi, G. Production\u00a0of conjugated linoleic acid (CLA) by lactiplantibacillus plantarum: a review with emphasis on fermented foods. 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Arab J Chem 2020;13:4237\u201345. https:\/\/doi.org\/10.1016\/j.arabjc.2019.07.005.","DOI":"10.1016\/j.arabjc.2019.07.005"},{"key":"2026053118020539437_j_znc-2025-0094_ref_031","doi-asserted-by":"crossref","unstructured":"Semaming, Y, Pannengpetch, P, Chattipakorn, SC, Chattipakorn, N. Pharmacological properties of protocatechuic acid and its potential roles as complementary medicine. Evid Based Complement Alternat Med 2015:593902. https:\/\/doi.org\/10.1155\/2015\/593902.","DOI":"10.1155\/2015\/593902"},{"key":"2026053118020539437_j_znc-2025-0094_ref_032","doi-asserted-by":"crossref","unstructured":"Vuolo, MM, Lima, VS, Junior, MRM. Phenolic compounds: structure, classification, and antioxidant power. In: Bioactive compounds. Amsterdam, The Netherlands: Elsevier; 2019:33\u201350 pp.","DOI":"10.1016\/B978-0-12-814774-0.00002-5"},{"key":"2026053118020539437_j_znc-2025-0094_ref_033","doi-asserted-by":"crossref","unstructured":"Fifere, A, Turin-Moleavin, IA, Rosca, I. 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Phytother Res 2000;14:510\u201316. https:\/\/doi.org\/10.1002\/1099-1573(200011)14:7%3C510::aid-ptr646%3E3.0.co;2-b.","DOI":"10.1002\/1099-1573(200011)14:7<510::AID-PTR646>3.0.CO;2-B"},{"key":"2026053118020539437_j_znc-2025-0094_ref_040","doi-asserted-by":"crossref","unstructured":"Goswami, D, Mahapatra, AD, Banerjee, S, Kar, A, Ojha, D, Mukherjee, PK, et al.. Boswellia serrata oleo-gum-resin and \u03b2-boswellic acid inhibits HSV-1 infection in\u00a0vitro through modulation of NF-\u043aB and p38 MAP kinase signaling. Phytomedicine 2018;51:94\u2013103. https:\/\/doi.org\/10.1016\/j.phymed.2018.10.016","DOI":"10.1016\/j.phymed.2018.10.016"},{"key":"2026053118020539437_j_znc-2025-0094_ref_041","doi-asserted-by":"crossref","unstructured":"Ali, WA, Hashim, HR. Inhibit of the virus infections by using aromatic oils, Saccharomyces cerevisiae, Boswellia Carterii and zinc. Sys Rev Pharm 2020;11:561\u20139.","DOI":"10.31838\/srp.2020.4.83"},{"key":"2026053118020539437_j_znc-2025-0094_ref_042","doi-asserted-by":"crossref","unstructured":"Yang, MS, Lim, YS, Oh, B, Park, SC, Yang, D, Hwang, SB, et al.. Antiviral and therapeutic effects of a mixture of Boswellia serrata, Commiphora myrrha, and propolis for SARS-CoV-2. Nat Prod Commun 2023;18. https:\/\/doi.org\/10.1177\/1934578X231180709","DOI":"10.1177\/1934578X231180709"},{"key":"2026053118020539437_j_znc-2025-0094_ref_043","doi-asserted-by":"crossref","unstructured":"Basir, NH, Ramle, AQ, Ng, MP, Tan, CH, Tiekink, ER, Sim, KS, et al.. Discovery of indoleninyl-pyrazolo [3, 4-b] pyridines as potent chemotherapeutic agents against colorectal cancer cells. 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Nat Prod Bioprospect 2022;12:9. https:\/\/doi.org\/10.1007\/s13659-022-00329-0.","DOI":"10.1007\/s13659-022-00329-0"},{"key":"2026053118020539437_j_znc-2025-0094_ref_046","doi-asserted-by":"crossref","unstructured":"Salaria, D, Rolta, R, Sharma, N, Patel, CN, Ghosh, A, Dev, K, et al.. In vitro and in\u00a0silico antioxidant and anti-inflammatory potential of essential oil of Cymbopogon citratus (DC.) Stapf. of North-Western Himalaya. J\u00a0Biomol Struct Dyn 2022;40:14131\u201345. https:\/\/doi.org\/10.1080\/07391102.2021.2001371.","DOI":"10.1080\/07391102.2021.2001371"},{"key":"2026053118020539437_j_znc-2025-0094_ref_047","doi-asserted-by":"crossref","unstructured":"Cai, B, Wan, P, Chen, H, Huang, J, Ye, Z, Chen, D, et al.. Purification and identification of novel myeloperoxidase inhibitory antioxidant peptides from tuna (Thunnas albacares) protein hydrolysates. 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Structural and functional characterization of aromatase, estrogen receptor, and their genes in endocrine-responsive and -resistant breast cancer cells. J\u00a0Steroid Biochem Mol Biol 2016;161:73\u201383. https:\/\/doi.org\/10.1016\/j.jsbmb.2015.07.018.","DOI":"10.1016\/j.jsbmb.2015.07.018"},{"key":"2026053118020539437_j_znc-2025-0094_ref_056","doi-asserted-by":"crossref","unstructured":"Farouk, F, Elmaaty, AA, Elkamhawy, A, Tawfik, HO, Alnajjar, R, Abourehab, MAS, et al.. Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in\u00a0vitro, molecular docking, molecular dynamics, and SAR studies. J\u00a0Enzym Inhib Med Chem 2023;38:2171029. https:\/\/doi.org\/10.1080\/14756366.2023.2171029.","DOI":"10.1080\/14756366.2023.2171029"},{"key":"2026053118020539437_j_znc-2025-0094_ref_057","doi-asserted-by":"crossref","unstructured":"Palaniappan, M. Current therapeutic opportunities for estrogen receptor mutant breast cancer. Biomedicines 2024;12:2700. https:\/\/doi.org\/10.3390\/biomedicines12122700.","DOI":"10.3390\/biomedicines12122700"},{"key":"2026053118020539437_j_znc-2025-0094_ref_058","doi-asserted-by":"crossref","unstructured":"Sundarraj, S, Thangam, R, Sreevani, V, Kaveri, K, Gunasekaran, P, Achiraman, S, et al.. \u03b3-Sitosterol from Acacia nilotica L. induces G2\/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells. J\u00a0Ethnopharmacol 2012;141:803\u20139. https:\/\/doi.org\/10.1016\/j.jep.2012.03.014.","DOI":"10.1016\/j.jep.2012.03.014"},{"key":"2026053118020539437_j_znc-2025-0094_ref_059","doi-asserted-by":"crossref","unstructured":"Hl, X, Cy, L, He, X, Niu, K, Peng, H, Ww, L, et al.. Molecular modeling, docking and dynamics simulations of GNA-related lectins for potential prevention of influenza virus (H1N1). J\u00a0Mol Model 2012;18:27\u201337. https:\/\/doi.org\/10.1007\/s00894-011-1022-7.","DOI":"10.1007\/s00894-011-1022-7"},{"key":"2026053118020539437_j_znc-2025-0094_ref_060","doi-asserted-by":"crossref","unstructured":"Sahoo, M, Jena, L, Rath, SN, Kumar, S. Identification of suitable natural inhibitor against influenza A (H1N1) neuraminidase\u00a0protein\u00a0by molecular docking. Genom Inform 2016;14:96. https:\/\/doi.org\/10.5808\/GI.2016.14.3.96.","DOI":"10.5808\/GI.2016.14.3.96"},{"key":"2026053118020539437_j_znc-2025-0094_ref_061","doi-asserted-by":"crossref","unstructured":"Kumar, M, Chung, SM, Enkhtaivan, G, Patel, RV, Shin, HS, Mistry, BM. Molecular docking studies and biological evaluation of berberine\u2013benzothiazole derivatives as an anti-influenza agent via blocking of neuraminidase. 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