{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:26:10Z","timestamp":1783441570697,"version":"3.54.6"},"reference-count":101,"publisher":"Walter de Gruyter GmbH","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Inula viscosa<\/jats:italic>\n                    is a common medicinal plant and is mostly spread in Mediterranean countries. The current study analyses\n                    <jats:italic>I.\u00a0viscosa<\/jats:italic>\n                    extracts for antimicrobial capacity, phenolic content, antioxidant, enzyme inhibition, and molecular modeling. The extracts\u2019 anticancer potential in prostate and breast cancer cells was evaluated, and their anti-metastatic and molecular activities were analyzed through gene expression. The most prevalent substances in the methanol extract of\n                    <jats:italic>I.\u00a0viscosa<\/jats:italic>\n                    are phenolic acids, which include derivatives of caffeic acid and mono-, di-, and tri-caffeoylquinic acids. Dicaffeoylquinic acids represented 88\u202f% of the quantified phenolics. The methanol extract showed a 50\u202f% inhibitor concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) of 101.4\u202f\u03bcg\/mL at 48\u202fh in PC3 cells. Autophagy-related genes were found to be down-regulated in all three cancer cells. Regarding antimetastatic activity, the wound width remained \u223c96\u202f% at 48\u202fh after ethyl acetate treatment in MCF-7\u202fcells. The water extract had the highest total phenolic content and the strongest antioxidant capacity, followed by the methanol extract. Modest binding potential to B-cell leukemia-2 (Bcl-2) was observed with caffeoylquinic acid and caffeic acid derivatives, which may be related to pro-apoptotic\/anticancer effects. Our results suggested that\n                    <jats:italic>I.\u00a0viscosa<\/jats:italic>\n                    can be considered as an effective raw material for designing health-promoting applications.\n                  <\/jats:p>","DOI":"10.1515\/znc-2025-0189","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:56:24Z","timestamp":1760781384000},"page":"503-525","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical characterization and multi-biological potentials of\n                    <i>Inula viscosa<\/i>\n                    : new\n                    <i>in\u00a0vitro<\/i>\n                    evidence"],"prefix":"10.1515","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2940-7464","authenticated-orcid":false,"given":"Yasemin","family":"Celik Altunoglu","sequence":"first","affiliation":[{"name":"Department of Genetics and Bioengineering, Faculty of Engineering and Architecture , 187466 Kastamonu University, Plantomics Research Laboratory , 37150 , Kastamonu , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ocal","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering, Faculty of Engineering and Architecture , 187466 Kastamonu University, Plantomics Research Laboratory , 37150 , Kastamonu , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Cengiz","family":"Baloglu","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering, Faculty of Engineering and Architecture , 187466 Kastamonu University, Plantomics Research Laboratory , 37150 , Kastamonu , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alsideeq Abdulsalam Ahmed","family":"Aboujanah","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering, Faculty of Engineering and Architecture , 187466 Kastamonu University, Plantomics Research Laboratory , 37150 , Kastamonu , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdo\u011fan","family":"Horuz","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering, Faculty of Engineering and Architecture , 187466 Kastamonu University, Plantomics Research Laboratory , 37150 , Kastamonu , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eulogio J.","family":"Llorent-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Physical and Analytical Chemistry , University of Ja\u00e9n, Campus Las Lagunillas S\/N , E-23071 , Ja\u00e9n , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullahi Ibrahim","family":"Uba","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science and Arts , Istanbul Arel University , Istanbul , 34537 , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Lazarova","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Pharmacy , Medical University-Sofia , 2, Dunav str., 1000 , Sofia , Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"G\u00f6khan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology, Science Faculty , Selcuk University, Campus , Konya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerim","family":"G\u00fcney","sequence":"additional","affiliation":[{"name":"Department of Forest Engineering, Faculty of Forestry , 187466 Kastamonu University , Kastamonu , 37150 , Kastamonu , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"2026070715574835718_j_znc-2025-0189_ref_001","doi-asserted-by":"crossref","unstructured":"RL Siegel, KD Miller, NS Wagle, A Jemal. 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Int J Environ Health Res 2023;34:1076\u201387. https:\/\/doi.org\/10.1080\/09603123.2023.2197641.","DOI":"10.1080\/09603123.2023.2197641"},{"key":"2026070715574835718_j_znc-2025-0189_ref_020","doi-asserted-by":"crossref","unstructured":"Migheli, R, Virdis, P, Galleri, G, Arru, C, Lostia, G, Coradduzza, D, et al.. Antineoplastic properties of Inula viscosa and its sesquiterpene lactones tomentosin and inuviscolide. Biomedicines 2022;10:2739. https:\/\/doi.org\/10.3390\/biomedicines10112739.","DOI":"10.3390\/biomedicines10112739"},{"key":"2026070715574835718_j_znc-2025-0189_ref_021","doi-asserted-by":"crossref","unstructured":"El Yaagoubi, OM, Lahmadi, A, Bouyahya, A, Filali, H, Samaki, H, El Antri, S, et al.. Antitumor effect of Inula viscosa extracts on DMBA-induced skin carcinoma are mediated by proteasome inhibition. 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