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Moreover,\n                    <jats:bold>HE<\/jats:bold>\n                    demonstrated apparent inhibitory activity against NS2B-NS3\n                    <jats:sup>pro<\/jats:sup>\n                    enzyme responsible for viral replication with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 48.5\u00a0\u00b1\u00a02.3\u202f\u03bcg\/mL. In the thrombocytopenia rats,\n                    <jats:bold>HE<\/jats:bold>\n                    -treated group showed a significant increase in platelet count (approximately 33.62\u202f%; p\u00a0&lt;\u00a00.05). Additionally, the bleeding time of 0.74\u202f\u202fg\/kg treatment group was significantly reduced by 33.4\u202f% (p\u00a0&lt;\u00a00.05). Antipyretic activity of\n                    <jats:bold>HE<\/jats:bold>\n                    in rabbits after 3-h treatment showed a significant reduction in body temperature (38.8\u202f%; \u0394T: 0.4\u00a0\u00b1\u00a00.1\u202f\u00b0C) at a dose of 0.31\u202fg\/kg. Thus, our findings provided new\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    and\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    evidence demonstrating the effect of\n                    <jats:bold>HE<\/jats:bold>\n                    in alleviating DHF.\n                  <\/jats:p>","DOI":"10.1515\/znc-2025-0197","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T15:20:05Z","timestamp":1765466405000},"page":"543-555","source":"Crossref","is-referenced-by-count":0,"title":["Anti-dengue fever activity of a polyherbal extract from medicinal plants of Vietnam"],"prefix":"10.1515","volume":"81","author":[{"given":"Vo Hoai","family":"Bac","sequence":"first","affiliation":[{"name":"Institute of Biology, Vietnam Academy of Science and Technology , 18 Hoang Quoc Viet Road, Cau Giay , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Thi","family":"Xoan","sequence":"additional","affiliation":[{"name":"National Institute of Medicinal Materials , 3B Quang Trung Street, Hoan Kiem , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi","family":"Thu Thuy","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology , 1 Yecxanh, Hai Ba Trung , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu Thi","family":"Bich Hau","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology , 1 Yecxanh, Hai Ba Trung , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Food Industrialization, Institutes of Green Bio Science and Technology, Seoul National University , Pyeongchang-gun , Gangwon-do , 25354 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Van Quyen","sequence":"additional","affiliation":[{"name":"Institute of Biology, Vietnam Academy of Science and Technology , 18 Hoang Quoc Viet Road, Cau Giay , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doman","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Food Industrialization, Institutes of Green Bio Science and Technology, Seoul National University , Pyeongchang-gun , Gangwon-do , 25354 , Republic of Korea"},{"name":"Graduate School of International Agricultural Technology, Seoul National University , Pyeongchang-gun , Gangwon-do , 25354 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi","family":"Phuong Trang","sequence":"additional","affiliation":[{"name":"Vietnam-Korea Institute of Science and Technology (VKIST), Hoa Lac High-tech Park , Km29 Thang Long Boulevard , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Van Tam","sequence":"additional","affiliation":[{"name":"VPO PHARCO Company , 688 Nguyen Thi Minh Khai Road , V\u0129nh Y\u00ean , Phu Tho , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Van Dung","sequence":"additional","affiliation":[{"name":"VPO PHARCO Company , 688 Nguyen Thi Minh Khai Road , V\u0129nh Y\u00ean , Phu Tho , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8094-6354","authenticated-orcid":false,"given":"Nguyen Thi","family":"Mai Phuong","sequence":"additional","affiliation":[{"name":"Institute of Biology, Vietnam Academy of Science and Technology , 18 Hoang Quoc Viet Road, Cau Giay , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"2026070715574828499_j_znc-2025-0197_ref_001","doi-asserted-by":"crossref","unstructured":"Gubler, DJ. 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