{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:32:08Z","timestamp":1793799128609,"version":"4.6.1"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"11-12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study investigates the phytochemical composition, antibacterial efficacy, and molecular interactions of\n                    <jats:italic>Anthocleista vogelii<\/jats:italic>\n                    stem barks extracts. Phytochemical screening revealed the presence of flavonoids, alkaloids, triterpenes, phenols, saponins, and other bioactive compounds in 95\u202f% ethanol and hydro-ethanol extracts, while coumarins, steroids, and anthraquinones were absent in aqueous extracts. The 95\u202f% ethanol extract demonstrated significant antibacterial activity against\n                    <jats:italic>Esherichia coli<\/jats:italic>\n                    (MIC: 64\u202f\u03bcg\/mL) and\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    (MIC: 8\u202f\u03bcg\/mL), with\u00a0moderate effects against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>A.\u00a0baumannii<\/jats:italic>\n                    , and\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Spp. (MIC: 512\u202f\u03bcg\/mL). Bactericidal activity (MBC\/MIC\u00a0\u2264\u00a04) paralleled ciprofloxacin, particularly against Gram-positive pathogens. LC-MS analysis identified nine bioactive flavone derivatives, including fabiatrin, kaempferitrin, quercitrin, and naringin. Molecular docking revealed these compounds exhibited superior binding affinities (\u22126.6 to\u00a0\u221211.7\u202fkcal\u202fmol\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) to\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    and\n                    <jats:italic>Salmonella typhi<\/jats:italic>\n                    targets compared to ciprofloxacin (\u22123.6 to\u00a0\u22125.4\u202fkcal\u202fmol\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), forming hydrogen bonds and\n                    <jats:italic>\u03c0<\/jats:italic>\n                    -interactions critical for inhibition. ADMET predictions indicated poor gastrointestinal absorption and AMES toxicity risks but favorable plasma protein binding and cardiac safety. Frontier Molecular Orbital (FMO) analysis highlighted quercetin\u2019s high reactivity (\u0394Egap: 3.70\u202feV) and naringin\u2019s stability. These findings position\n                    <jats:italic>A.\u00a0vogelii<\/jats:italic>\n                    as a rich source of antimicrobial phytochemicals, though further optimization is needed to address pharmacokinetic limitations.\n                  <\/jats:p>","DOI":"10.1515\/znc-2025-0229","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:45:46Z","timestamp":1773351946000},"page":"763-777","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical and antibacterial studies of the ethanolic stem barks extract of\n                    <i>Anthocleista vogelii<\/i>\n                    planch, and the\n                    <i>in silico<\/i>\n                    study of its secondary metabolites on two bacteria strains\n                    <i>Staphylococcus aureus<\/i>\n                    and\n                    <i>Salmonella typhi<\/i>"],"prefix":"10.1515","volume":"81","author":[{"given":"Tengu","family":"Awazi","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science , 361552 University of Douala , P.O. Box\u00a024157 , Douala , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith Caroline","family":"Ngo Nyobe","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmaceutical Sciences , University of Douala , P.O. Box\u00a002701 , Douala , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baruch Ateba","family":"Amana","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science , 361552 University of Douala , P.O. Box\u00a024157 , Douala , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemencia","family":"Iwo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science , 361552 University of Douala , P.O. Box\u00a024157 , Douala , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maraf Mbah","family":"Bake","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Computational Chemistry Laboratory , Higher Teacher Training College, University of Yaound\u00e9 I , P.O Box\u00a047 , Yaound\u00e9 , Cameroon"},{"name":"Physical and Theoretical Chemistry Unit, Laboratory of Applied Physical and Analytical Chemistry, Faculty of Science , University of Yaound\u00e9 I , P.O Box\u00a0812 , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Merlin","family":"Tsahnang Fofack","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science , 361552 University of Douala , P.O. Box\u00a024157 , Douala , Cameroon"},{"name":"Laboratoire Optique et Applications, Centre de Physique Atomique Mol\u00e9culaire et Optique Quantique, Facult\u00e9 des Sciences , Universit\u00e9 de Douala , BP 24157 , Douala , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7506-5798","authenticated-orcid":false,"given":"Pierre Roger","family":"Koliye","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science , 361552 University of Douala , P.O. 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