{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:33:13Z","timestamp":1793799193484,"version":"4.6.1"},"reference-count":58,"publisher":"Walter de Gruyter GmbH","issue":"11-12","funder":[{"name":"The German Science Foundation (DFG) for funding","award":["417637295"],"award-info":[{"award-number":["417637295"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The development of metal-based anticancer agents has been a significant area of research since the discovery of cisplatin\u2019s cytostatic effects. In this study, we investigate the cytotoxicity of tridentate ligands derived from 2-phenyl-6-(1,2,3-triazol-4-yl)pyridine and their platinum(II) and palladium(II) complexes against various human cancer cell lines and normal fibroblasts. Several complexes exhibit high cytotoxicity, particularly against acute T-lymphoblastic leukemia cells (CCRF-CEM). Notably, a platinum(II) complex containing an acylpyrrolidine ligand demonstrates remarkable cancer cell selectivity with a sub-micromolar IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 0.17\u202f\u03bcM. Cell cycle analysis revealed that these compounds induce apoptosis and affect DNA\/RNA synthesis. Additionally, some complexes show significant antimicrobial activity against Gram-positive bacteria and yeast. Our findings highlight the potential of these metal complexes as selective anticancer agents and underscore the importance of further mechanistic studies.\n                  <\/jats:p>","DOI":"10.1515\/znc-2025-0262","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:33:16Z","timestamp":1780090396000},"page":"809-824","source":"Crossref","is-referenced-by-count":0,"title":["Cytotoxicity and antimicrobial activity of platinum(II) complexes based on the ligand precursor 2-phenyl-6-(1,2,3-triazol-4-yl)pyridine\u00a0\u2013\u00a0influence of substituent and ancillary ligand on selectivity and activity"],"prefix":"10.1515","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-5165","authenticated-orcid":false,"given":"Marian","family":"Hebenbrock","sequence":"first","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster , Corrensstr. 28\/30, 48149 M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u0148a","family":"Gursk\u00e1","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry , Institute of Molecular and Translational Medicine, Palack\u00fd University and University Hospital Olomouc , Hn\u011bvot\u00ednsk\u00e1 1333\/5, 779\u00a000 , Olomouc , Czech Republic"},{"name":"Institute of Molecular and Translational Medicine, Czech Advanced Technology and Research Institute (CATRIN), Palack\u00fd University Olomouc , Hn\u011bvot\u00ednsk\u00e1 1333\/5, 779\u00a000 , Olomouc , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate\u0159ina","family":"Bogdanov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine and Dentistry , Palack\u00fd University , Hn\u011bvot\u00ednsk\u00e1 3, 775\u00a015 , Olomouc , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00fdna","family":"Re\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine and Dentistry , Palack\u00fd University , Hn\u011bvot\u00ednsk\u00e1 3, 775\u00a015 , Olomouc , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Kol\u00e1\u0159","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine and Dentistry , Palack\u00fd University , Hn\u011bvot\u00ednsk\u00e1 3, 775\u00a015 , Olomouc , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Boisten","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster , Corrensstr. 28\/30, 48149 M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00e1n","family":"Hajd\u00fach","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry , Institute of Molecular and Translational Medicine, Palack\u00fd University and University Hospital Olomouc , Hn\u011bvot\u00ednsk\u00e1 1333\/5, 779\u00a000 , Olomouc , Czech Republic"},{"name":"Institute of Molecular and Translational Medicine, Czech Advanced Technology and Research Institute (CATRIN), Palack\u00fd University Olomouc , Hn\u011bvot\u00ednsk\u00e1 1333\/5, 779\u00a000 , Olomouc , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"D\u017eub\u00e1k","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry , Institute of Molecular and Translational Medicine, Palack\u00fd University and University Hospital Olomouc , Hn\u011bvot\u00ednsk\u00e1 1333\/5, 779\u00a000 , Olomouc , Czech Republic"},{"name":"Institute of Molecular and Translational Medicine, Czech Advanced Technology and Research Institute (CATRIN), Palack\u00fd University Olomouc , Hn\u011bvot\u00ednsk\u00e1 1333\/5, 779\u00a000 , Olomouc , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4713-0606","authenticated-orcid":false,"given":"Jens","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Analytical Chemistry, University of M\u00fcnster , Corrensstr. 28\/30, 48149 M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"2026110413024096079_j_znc-2025-0262_ref_001","doi-asserted-by":"crossref","unstructured":"Wiltshaw, E. 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