{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T14:27:34Z","timestamp":1748269654622},"reference-count":52,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An unexpectedly detected prolonged activated partial thromboplastin time (APTT) can be a harmless laboratory finding, but can also reflect a thrombotic tendency or a bleeding disorder. The assistance of laboratory professionals in the interpretation of an unexpectedly detected prolonged APTT (uAPTT) is often required. The way in which uAPTTs are evaluated in laboratories was assessed in this international study with the aim of determining whether laboratory professionals are able to fulfill this need.<\/jats:p><jats:p>Postanalytical practices after uAPTT were investigated and the mixing study methodology (if used) was studied by circulating a case report with a questionnaire to staff in the invited laboratories. In addition, the interpretations of those staff regarding the presence or absence of inhibitors in three APTT mixing study scenarios were examined.<\/jats:p><jats:p>Large within- and between-country variations were detected in both postanalytical practices and mixing study methodologies among the 990 responding laboratories, 90% of which were in 13 countries. Shortcomings regarding the investigation of uAPTTs leading to potentially incorrect or delayed clinical diagnoses were found in 88% of the laboratories. Of the laboratories to which the interpretative questions were sent, 49% interpreted all mixing study scenarios correctly. uAPTTs were investigated appropriately and all mixing study scenarios interpreted correctly in parallel in only 9.6% of the participating laboratories.<\/jats:p><jats:p>The clinical requirement for the assistance of laboratory professionals in the interpretation of uAPTTs cannot be met at most of the participating laboratories. Laboratory professionals should be trained in the evaluation of ordinary laboratory tests, such as that for uAPTTs.<\/jats:p>","DOI":"10.1515\/cclm-2014-1183","type":"journal-article","created":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T17:23:26Z","timestamp":1424712206000},"source":"Crossref","is-referenced-by-count":9,"title":["An international study of how laboratories handle and evaluate patient samples after detecting an unexpected APTT prolongation"],"prefix":"10.1515","volume":"53","author":[{"given":"\u00c9va","family":"Ajzner","sequence":"first","affiliation":[]},{"given":"Dunja","family":"Rogic","sequence":"additional","affiliation":[]},{"given":"Piet","family":"Meijer","sequence":"additional","affiliation":[]},{"given":"Ann Helen","family":"Kristoffersen","sequence":"additional","affiliation":[]},{"given":"Paolo","family":"Carraro","sequence":"additional","affiliation":[]},{"given":"Eser","family":"Sozmen","sequence":"additional","affiliation":[]},{"given":"Ana Paula","family":"Faria","sequence":"additional","affiliation":[]},{"given":"Sverre","family":"Sandberg","sequence":"additional","affiliation":[]},{"family":"on behalf of the joint Working Grou","sequence":"additional","affiliation":[]}],"member":"374","reference":[{"key":"ref131","first-page":"712","article-title":"Pre - 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pre and post - post analytical error : high - incidence patient safety hazards involving the clinical laboratory","author":"Laposata","year":"2007","journal-title":"Clin Chem Lab Med"},{"key":"ref81","first-page":"1","article-title":"Laboratory assays In editors The clinical hemostasis handbook st ed Chicago Year Book Medical Publisher","author":"Laposata","year":"1989","journal-title":"IL"},{"key":"ref201","first-page":"73","article-title":"den Mauser The Nijmegen modification of the Bethesda assay for factor VIII inhibitors improved specificity and reliability","author":"Verbruggen","year":"1995"},{"key":"ref71","article-title":"National Committee for Clinical Laboratory Standards One - stage prothrombin time and activated partial thromboplastin time test approved guideline document vol no","volume":"28","author":"APTT","year":"1996"},{"key":"ref251","first-page":"472","article-title":"Patient - specific narrative interpretations of complex clinical laboratory evaluations : who is competent to provide them editorial","author":"Laposata","year":"2004","journal-title":"Clin Chem"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/ajh.23285","article-title":"MB The isolated prolonged PTT","volume":"88","author":"Tcherniantchouk","year":"2013","journal-title":"Am J Hematol"},{"key":"ref361","first-page":"1","article-title":"Laboratory assays In editors The clinical hemostasis handbook st ed Chicago Year Book Medical Publisher","author":"Laposata","year":"1989","journal-title":"IL"},{"key":"ref261","first-page":"39","article-title":"Problems and solutions in laboratory testing for hemophilia","author":"Favaloro","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"864","DOI":"10.4065\/82.7.864","article-title":"How to interpret and pursue an abnormal prothrombin time activated partial thromboplastin time and bleeding time in adults","author":"Kamal","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/jaut.2000.0392","article-title":"Conceptions and misconceptions in testing for lupus anticoagulants","volume":"15","author":"Exner","year":"2000","journal-title":"J Autoimmun"},{"key":"ref401","doi-asserted-by":"crossref","DOI":"10.1515\/cclm-2011-0611","article-title":"de Reflective testing adding value to laboratory testing","author":"Verboeket","year":"2012","journal-title":"Clin Chem Lab Med"},{"key":"ref281","first-page":"648","article-title":"Differential diagnosis of the bleeding patient In II editors thrombosis basic principles and clinical practice th ed Philadelphia","author":"Johnsen","year":"2014","journal-title":"Haemostasis"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1373\/clinchem.2003.024877","article-title":"Quality assessment of interpretative commenting in clinical chemistry","author":"Lim","year":"2004","journal-title":"Clin Chem"},{"key":"ref441","article-title":"Enterprise Enterprise survey software and research tools Available from http www surveymonkey com Accessed","author":"SurveyMonkey","year":"2012"},{"key":"ref61","first-page":"39","article-title":"Mixing tests : diagnostic aides in the investigation of prolonged prothrombin times and activated partial thromboplastin times","author":"Kershaw","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"ref341","first-page":"39","article-title":"Mixing tests : diagnostic aides in the investigation of prolonged prothrombin times and activated partial thromboplastin times","author":"Kershaw","year":"2013","journal-title":"Semin Thromb Hemost"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2014-1183\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T10:44:47Z","timestamp":1717757087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/cclm-2014-1183\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":52,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.1515\/cclm-2014-1183","relation":{},"ISSN":["1437-4331","1434-6621"],"issn-type":[{"value":"1437-4331","type":"electronic"},{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}