{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:14:22Z","timestamp":1767665662943},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Chemistry"],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have recently investigated the long-recognized relationship between complex I and group 4 [NiFe] hydrogenases and we have established the so-called <jats:underline>E<\/jats:underline>nergy-converting <jats:underline>h<\/jats:underline>ydrogenase <jats:underline>r<\/jats:underline>elated (Ehr) complex as a new member of the family. We have also observed that four subunits, homologues to NuoB, D, H and L, are common to the members of the family. We have designated this common group of subunits the universal adaptor. Taking into account the similarity of the Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> antiporter-like subunits of complex I (NuoL, NuoM and NuoN) and the unique structural characteristic of the long amphipathic \u03b1 helix part of NuoL, the nature of the antiporter-like subunit of the universal adaptor was questioned. Thus, in this work we further explore the properties of the universal adaptor, investigating which antiporter-like subunit is part of the universal adaptor. We observe that the universal adaptor contains an antiporter-like subunit with a long amphipathic \u03b1 helix, similar to NuoL. Consequently, the long helix is a common denominator that has been conserved in all members of the family. Such conservation surely reflects the key role of such helix in the energy transduction mechanism of this family of enzymes.<\/jats:p>","DOI":"10.1515\/hsz-2012-0342","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T14:08:58Z","timestamp":1366034938000},"page":"659-666","source":"Crossref","is-referenced-by-count":15,"title":["The antiporter-like subunit constituent of the universal adaptor of complex I, group 4 membrane-bound [NiFe]-hydrogenases and related complexes"],"prefix":"10.1515","volume":"394","author":[{"given":"Ana P.","family":"Batista","sequence":"first","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica, Universidade Nova de Lisboa, Av. da Rep\u00fablica EAN, 2780-157 Oeiras, Portugal"}]},{"given":"Bruno C.","family":"Marreiros","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica, Universidade Nova de Lisboa, Av. da Rep\u00fablica EAN, 2780-157 Oeiras, Portugal"}]},{"given":"Manuela M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica, Universidade Nova de Lisboa, Av. da Rep\u00fablica EAN, 2780-157 Oeiras, Portugal"}]}],"member":"374","published-online":{"date-parts":[[2013,3,14]]},"container-title":["bchm"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/bchm.2013.394.issue-5\/hsz-2012-0342\/hsz-2012-0342.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/hsz-2012-0342\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/hsz-2012-0342\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T15:22:25Z","timestamp":1647271345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/hsz-2012-0342\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,14]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,1,28]]},"published-print":{"date-parts":[[2013,5,1]]}},"alternative-id":["10.1515\/hsz-2012-0342"],"URL":"https:\/\/doi.org\/10.1515\/hsz-2012-0342","relation":{},"ISSN":["1437-4315","1431-6730"],"issn-type":[{"value":"1437-4315","type":"electronic"},{"value":"1431-6730","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3,14]]}}}