{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:51:13Z","timestamp":1774450273853,"version":"3.50.1"},"reference-count":280,"publisher":"Walter de Gruyter GmbH","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>White adipose tissue (WAT) is actively involved in the regulation of whole-body energy homeostasis via storage\/release of lipids and adipokine secretion. Current research links WAT dysfunction to the development of metabolic syndrome (MetS) and type 2 diabetes (T2D). The expansion of WAT during oversupply of nutrients prevents ectopic fat accumulation and requires proper preadipocyte-to-adipocyte differentiation. An assumed link between excess levels of reactive oxygen species (ROS), WAT dysfunction and T2D has been discussed controversially. While oxidative stress conditions have conclusively been detected in WAT of T2D patients and related animal models, clinical trials with antioxidants failed to prevent T2D or to improve glucose homeostasis. Furthermore, animal studies yielded inconsistent results regarding the role of oxidative stress in the development of diabetes. Here, we discuss the contribution of ROS to the (patho)physiology of adipocyte function and differentiation, with particular emphasis on sources and nutritional modulators of adipocyte ROS and their functions in signaling mechanisms controlling adipogenesis and functions of mature fat cells. We propose a concept of ROS balance that is required for normal functioning of WAT. We explain how both excessive and diminished levels of ROS, e.g. resulting from over supplementation with antioxidants, contribute to WAT dysfunction and subsequently insulin resistance.<\/jats:p>","DOI":"10.1515\/hsz-2015-0305","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T17:38:29Z","timestamp":1459445909000},"page":"709-724","source":"Crossref","is-referenced-by-count":133,"title":["The two faces of reactive oxygen species (ROS) in adipocyte function and dysfunction"],"prefix":"10.1515","volume":"397","author":[{"given":"Jos\u00e9 Pedro","family":"Castro","sequence":"first","affiliation":[]},{"given":"Tilman","family":"Grune","sequence":"additional","affiliation":[]},{"given":"Bodo","family":"Speckmann","sequence":"additional","affiliation":[]}],"member":"374","reference":[{"key":"ref1211","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nature02866","article-title":"Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity","volume":"431","year":"2004","journal-title":"Nature"},{"key":"ref2601","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1073\/pnas.96.11.6223","article-title":"Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones","volume":"96","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1021\/pr500324y","article-title":"Carbonylated plasma proteins as potential biomarkers of obesity induced type 2 diabetes mellitus","volume":"13","year":"2014","journal-title":"J. Proteome. Res."},{"key":"ref811","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.1016\/S0021-9258(20)81883-3","article-title":"Induction of lipogenesis during differentiation in a \u201cpreadipocyte\u201d cell line","volume":"251","year":"1976","journal-title":"J. Biol. Chem."},{"key":"ref851","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/nm.2014","article-title":"A crucial role for adipose tissue p53 in the regulation of insulin resistance","volume":"15","year":"2009","journal-title":"Nat. Med."},{"key":"ref1701","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tem.2011.12.008","article-title":"Linking mitochondrial bioenergetics to insulin resistance via redox biology","volume":"23","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"ref911","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1101\/gad.1089403","article-title":"Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2","volume":"17","year":"2003","journal-title":"Genes. Dev."},{"key":"ref1681","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/MJT.0b013e318269175f","article-title":"A randomized, placebo-controlled trial of selenium supplementation in patients with type 2 diabetes: effects on glucose homeostasis, oxidative stress, and lipid profile","volume":"21","year":"2014","journal-title":"Am. J. Ther."},{"key":"ref2751","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1194\/jlr.M400031-JLR200","article-title":"Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes","volume":"45","year":"2004","journal-title":"J. Lipid. Res."},{"key":"ref1851","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1104\/pp.106.077073","article-title":"Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life","volume":"141","year":"2006","journal-title":"Plant Physiol."},{"key":"ref2421","first-page":"E281","article-title":"Effect of liposome-adipocyte interaction on hexose uptake and insulin action","volume":"241","year":"1981","journal-title":"Am. J. Physiol."},{"key":"ref471","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/geronj\/11.3.298","article-title":"Aging: a theory based on free radical and radiation chemistry","volume":"11","year":"1956","journal-title":"J. Gerontol."},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1001\/jama.2013.277028","article-title":"Antioxidant supplements to prevent mortality","volume":"310","year":"2013","journal-title":"J. Am. Med. Assoc."},{"key":"ref1201","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1073\/pnas.96.11.6223","article-title":"Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones","volume":"96","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref1501","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.2337\/diabetes.54.8.2277","article-title":"Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss","volume":"54","year":"2005","journal-title":"Diabetes"},{"key":"ref1261","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1073\/pnas.1000031107","article-title":"Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis","volume":"107","year":"2010a","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref1911","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/S0891-5849(00)00252-5","article-title":"Reactive oxygen species, cell signaling, and cell injury","volume":"28","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref741","doi-asserted-by":"crossref","first-page":"10601","DOI":"10.1074\/jbc.M808742200","article-title":"Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion","volume":"284","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref901","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2265.2011.04141.x","article-title":"The relationship between fat depot-specific preadipocyte differentiation and metabolic syndrome in obese women","volume":"76","year":"2012","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"ref2331","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","year":"1999","journal-title":"Science"},{"key":"ref931","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","year":"1999","journal-title":"Science"},{"key":"ref1051","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/emboj.2011.65","article-title":"Extensive chromatin remodelling and establishment of transcription factor \u2018hotspots\u2019 during early adipogenesis","volume":"30","year":"2011","journal-title":"EMBO J."},{"key":"ref1581","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.2337\/db09-1105","article-title":"Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction","volume":"59","year":"2010","journal-title":"Diabetes"},{"key":"ref2071","doi-asserted-by":"crossref","first-page":"B31","DOI":"10.1093\/geronj\/49.1.B31","article-title":"Effects of age and anatomic site on preadipocyte number in rat fat depots","volume":"49","year":"1994","journal-title":"J. Gerontol."},{"key":"ref1141","first-page":"948","article-title":"Adipose-cell size and immunoreactive insulin levels in obese and normal-weight adults","volume":"2","year":"1972","journal-title":"Lancet"},{"key":"ref1511","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.devcel.2010.02.018","article-title":"S6K1 plays a critical role in early adipocyte differentiation","volume":"18","year":"2010","journal-title":"Dev. Cell"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1212\/01.wnl.0000192308.43151.63","article-title":"Preferential degradation of oxidized proteins by the 20S proteasome may be inhibited in aging and in inflammatory neuromuscular diseases","volume":"66","year":"2006","journal-title":"Neurology"},{"key":"ref991","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nrm2066","article-title":"Adipocyte differentiation from the inside out","volume":"7","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref451","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1104\/pp.106.077073","article-title":"Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life","volume":"141","year":"2006","journal-title":"Plant Physiol."},{"key":"ref2031","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.freeradbiomed.2012.05.039","article-title":"Chaperones, but not oxidized proteins, are ubiquitinated after oxidative stress","volume":"53","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref2171","doi-asserted-by":"crossref","first-page":"10888","DOI":"10.1016\/S0021-9258(19)70390-1","article-title":"Effects of hydrogen peroxide on basal and hormone-stimulated lipolysis in perifused rat fat cells in relation to the mechanism of action of insulin","volume":"255","year":"1980","journal-title":"J. Biol. Chem."},{"key":"ref601","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.mam.2009.04.001","article-title":"The proteasomal system","volume":"30","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"ref1031","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/sj.emboj.7601623","article-title":"Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4","volume":"26","year":"2007","journal-title":"EMBO J."},{"key":"ref521","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.freeradbiomed.2014.02.028","article-title":"Pathophysiological importance of aggregated damaged proteins","volume":"71","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref1351","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1194\/jlr.M400031-JLR200","article-title":"Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes","volume":"45","year":"2004","journal-title":"J. Lipid. Res."},{"key":"ref141","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11010-014-2236-7","article-title":"Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects","volume":"399","year":"2015","journal-title":"Mol. Cell Biochem."},{"key":"ref391","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1074\/mcp.M600120-MCP200","article-title":"Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal","volume":"6","year":"2007","journal-title":"Mol. Cell Proteomics"},{"key":"ref1311","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","year":"2003","journal-title":"J. Clin. Invest."},{"key":"ref321","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3945\/an.112.003319","article-title":"Protein carbonylation, mitochondrial dysfunction, and insulin resistance","volume":"4","year":"2013","journal-title":"Adv. Nutrition"},{"key":"ref2631","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1172\/JCI28570.","article-title":"TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents","volume":"116","year":"2006","journal-title":"J. Clin. Invest."},{"key":"ref2511","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.freeradbiomed.2013.07.016","article-title":"Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism","volume":"65","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref381","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2337\/diabetes.54.2.311","article-title":"Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets","volume":"54","year":"2005","journal-title":"Diabetes"},{"key":"ref1481","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.exger.2010.01.003","article-title":"The sites and topology of mitochondrial superoxide production","volume":"45","year":"2010","journal-title":"Exp. Gerontol."},{"key":"ref2041","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.2337\/diabetes.53.11.2748","article-title":"regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis","volume":"53","year":"2004","journal-title":"Diabetes"},{"key":"ref1081","first-page":"1110","article-title":"Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis","volume":"20","year":"2014","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref2581","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1474-9726.2010.00608.x","article-title":"Fat tissue, aging, and cellular senescence","volume":"9","year":"2010","journal-title":"Aging Cell"},{"key":"ref1331","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.2337\/db11-1716","article-title":"Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice","volume":"61","year":"2012","journal-title":"Diabetes"},{"key":"ref1011","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbrc.2004.04.010","article-title":"Targets for TNF-alpha-induced lipolysis in human adipocytes","volume":"318","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref51","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref1041","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1161\/ATVBAHA.108.174219","article-title":"Nox4 acts as a switch between differentiation and proliferation in preadipocytes","volume":"29","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref2091","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.bbadis.2013.05.007","article-title":"Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis","volume":"1842","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref1621","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1212\/01.wnl.0000192308.43151.63","article-title":"Preferential degradation of oxidized proteins by the 20S proteasome may be inhibited in aging and in inflammatory neuromuscular diseases","volume":"66","year":"2006","journal-title":"Neurology"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1741-7007-7-38","article-title":"Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes","volume":"7","year":"2009","journal-title":"BMC Biol."},{"key":"ref1181","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1474-9726.2010.00608.x","article-title":"Fat tissue, aging, and cellular senescence","volume":"9","year":"2010","journal-title":"Aging Cell"},{"key":"ref841","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1016\/S0021-9258(17)30209-0","article-title":"Insulin-stimulated intracellular hydrogen peroxide production in rat epididymal fat cells","volume":"254","year":"1979","journal-title":"J. Biol. Chem."},{"key":"ref1301","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12937-015-0007-2","article-title":"The association between dietary selenium intake and diabetes: a cross-sectional study among middle-aged and older adults","volume":"14","year":"2015","journal-title":"Nutr. J."},{"key":"ref81","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.exger.2010.01.003","article-title":"The sites and topology of mitochondrial superoxide production","volume":"45","year":"2010","journal-title":"Exp. Gerontol."},{"key":"ref441","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrm2391","article-title":"Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes","volume":"9","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref2411","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbrc.2004.04.010","article-title":"Targets for TNF-alpha-induced lipolysis in human adipocytes","volume":"318","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref101","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.2337\/diabetes.54.8.2277","article-title":"Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss","volume":"54","year":"2005","journal-title":"Diabetes"},{"key":"ref1661","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1172\/JCI111075","article-title":"Influence of anatomic site and age on the replication and differentiation of rat adipocyte precursors in culture","volume":"72","year":"1983","journal-title":"J. Clin. Invest."},{"key":"ref351","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","year":"2004","journal-title":"J. Clin. Invest."},{"key":"ref1551","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0014-5793(04)00112-7","article-title":"Redox regulation of PTEN and protein tyrosine phosphatases in H2O2 mediated cell signaling","volume":"560","year":"2004","journal-title":"FEBS Lett."},{"key":"ref2641","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.biocel.2011.03.002","article-title":"Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity","volume":"43","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref2571","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.2337\/diabetes.51.7.2045","article-title":"Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes","volume":"51","year":"2002","journal-title":"Diabetes"},{"key":"ref2621","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3945\/jn.108.096131","article-title":"Tocotrienol suppresses adipocyte differentiation and Akt phosphorylation in 3T3-L1 preadipocytes","volume":"139","year":"2009","journal-title":"J. Nutr."},{"key":"ref401","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1074\/jbc.270.5.2344","article-title":"Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome","volume":"270","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref1241","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.biocel.2011.03.002","article-title":"Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity","volume":"43","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref1791","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1074\/mcp.M600120-MCP200","article-title":"Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal","volume":"6","year":"2007","journal-title":"Mol. Cell Proteomics"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.freeradbiomed.2011.06.033","article-title":"Cross talk between mitochondria and NADPH oxidases","volume":"51","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref1691","doi-asserted-by":"crossref","first-page":"e18532","DOI":"10.1371\/journal.pone.0018532","article-title":"Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis","volume":"6","year":"2011","journal-title":"PLoS One"},{"key":"ref91","first-page":"393192","article-title":"Adipose tissue dysfunction in nascent metabolic syndrome","volume":"2013","year":"2013","journal-title":"J. Obes."},{"key":"ref971","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1042\/bj3350637","article-title":"Comparative resistance of the 20S and 26S proteasome to oxidative stress","volume":"335","year":"1998","journal-title":"Biochem. J."},{"key":"ref2441","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1161\/ATVBAHA.108.174219","article-title":"Nox4 acts as a switch between differentiation and proliferation in preadipocytes","volume":"29","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref2301","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2265.2011.04141.x","article-title":"The relationship between fat depot-specific preadipocyte differentiation and metabolic syndrome in obese women","volume":"76","year":"2012","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1089\/ars.2014.5939","article-title":"Proteasome dysfunction associated to oxidative stress and proteotoxicity in adipocytes compromises insulin sensitivity in human obesity","volume":"23","year":"2015","journal-title":"Antioxid. Redox. Signal."},{"key":"ref2721","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1097-2765(00)80306-8","article-title":"Cross-regulation of C\/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity","volume":"3","year":"1999","journal-title":"Mol. Cell"},{"key":"ref641","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.2337\/diabetes.53.11.2748","article-title":"regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis","volume":"53","year":"2004","journal-title":"Diabetes"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0006-291X(03)00809-X","article-title":"Selective degradation of oxidatively modified protein substrates by the proteasome","volume":"305","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref491","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/152308603770310202","article-title":"The free radical theory of aging","volume":"5","year":"2003","journal-title":"Antioxid. Redox. Signal"},{"key":"ref1521","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0014-5793(03)00862-7","article-title":"Inhibition of preadipocyte proliferation by mitochondrial reactive oxygen species","volume":"550","year":"2003","journal-title":"FEBS Lett."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-394625-6.00001-5","article-title":"The mitochondrial free radical theory of aging","volume":"127","year":"2014","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref871","doi-asserted-by":"crossref","first-page":"f10","DOI":"10.1136\/bmj.f10","article-title":"Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials","volume":"346","year":"2013","journal-title":"Br. Med. J."},{"key":"ref1091","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/hep.22526","article-title":"Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors","volume":"48","year":"2008","journal-title":"Hepatology"},{"key":"ref1491","first-page":"393192","article-title":"Adipose tissue dysfunction in nascent metabolic syndrome","volume":"2013","year":"2013","journal-title":"J. Obes."},{"key":"ref1291","first-page":"45","article-title":"Histone H3K9 methyltransferase G9a represses PPARgamma expression and adipogenesis","volume":"32","year":"2013b","journal-title":"EMBO J."},{"key":"ref281","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/MJT.0b013e318269175f","article-title":"A randomized, placebo-controlled trial of selenium supplementation in patients with type 2 diabetes: effects on glucose homeostasis, oxidative stress, and lipid profile","volume":"21","year":"2014","journal-title":"Am. J. Ther."},{"key":"ref1891","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/152308603770310202","article-title":"The free radical theory of aging","volume":"5","year":"2003","journal-title":"Antioxid. Redox. Signal"},{"key":"ref2231","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1128\/MCB.24.5.1844-1854.2004","article-title":"The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction","volume":"24","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"ref2501","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1749-6632.2000.tb06187.x","article-title":"Protein oxidation","volume":"899","year":"2000","journal-title":"Ann. NY Acad. Sci."},{"key":"ref511","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/S0891-5849(00)00252-5","article-title":"Reactive oxygen species, cell signaling, and cell injury","volume":"28","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref1151","doi-asserted-by":"crossref","first-page":"217","DOI":"10.7326\/0003-4819-147-4-200708210-00175","article-title":"Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial","volume":"147","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"ref2481","first-page":"1110","article-title":"Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis","volume":"20","year":"2014","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref1781","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2337\/diabetes.54.2.311","article-title":"Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets","volume":"54","year":"2005","journal-title":"Diabetes"},{"key":"ref1391","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.freeradbiomed.2013.07.012","article-title":"Selenium and diabetes\u2013evidence from animal studies","volume":"65","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref2551","doi-asserted-by":"crossref","first-page":"217","DOI":"10.7326\/0003-4819-147-4-200708210-00175","article-title":"Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial","volume":"147","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"ref2011","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","year":"2006","journal-title":"Nature"},{"key":"ref1071","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","year":"2015","journal-title":"Redox. Biol."},{"key":"ref1231","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1172\/JCI28570.","article-title":"TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents","volume":"116","year":"2006","journal-title":"J. Clin. Invest."},{"key":"ref1991","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.metabol.2014.01.009","article-title":"Differences in the redox status of human visceral and subcutaneous adipose tissues\u2013relationships to obesity and metabolic risk","volume":"63","year":"2014","journal-title":"Metabolism"},{"key":"ref2561","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.4161\/epi.29856","article-title":"Methylome, transcriptome, and PPAR(gamma) cistrome analyses reveal two epigenetic transitions in fat cells","volume":"9","year":"2014","journal-title":"Epigenetics"},{"key":"ref2201","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00125-006-0572-1","article-title":"Fat cell enlargement is an independent marker of insulin resistance and \u2018hyperleptinaemia\u2019","volume":"50","year":"2007","journal-title":"Diabetologia"},{"key":"ref1841","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrm2391","article-title":"Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes","volume":"9","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref2141","doi-asserted-by":"crossref","first-page":"10601","DOI":"10.1074\/jbc.M808742200","article-title":"Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion","volume":"284","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref2491","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/hep.22526","article-title":"Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors","volume":"48","year":"2008","journal-title":"Hepatology"},{"key":"ref2781","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.1128\/MCB.23.22.8137-8151.2003","article-title":"Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress","volume":"23","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"ref291","doi-asserted-by":"crossref","first-page":"e18532","DOI":"10.1371\/journal.pone.0018532","article-title":"Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis","volume":"6","year":"2011","journal-title":"PLoS One"},{"key":"ref1601","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1471-4914(03)00031-5","article-title":"Protein carbonylation in human diseases","volume":"9","year":"2003","journal-title":"Trends Mol. Med."},{"key":"ref651","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1194\/jlr.M034603","article-title":"Dexamethasone-induced selenoprotein S degradation is required for adipogenesis","volume":"54","year":"2013","journal-title":"J. Lipid. Res."},{"key":"ref1751","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","year":"2004","journal-title":"J. Clin. Invest."},{"key":"ref591","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.metabol.2014.01.009","article-title":"Differences in the redox status of human visceral and subcutaneous adipose tissues\u2013relationships to obesity and metabolic risk","volume":"63","year":"2014","journal-title":"Metabolism"},{"key":"ref1871","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/geronj\/11.3.298","article-title":"Aging: a theory based on free radical and radiation chemistry","volume":"11","year":"1956","journal-title":"J. Gerontol."},{"key":"ref2181","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cmet.2009.08.009","article-title":"Reactive oxygen species enhance insulin sensitivity","volume":"10","year":"2009","journal-title":"Cell Metab."},{"key":"ref701","doi-asserted-by":"crossref","first-page":"10942","DOI":"10.1016\/S0021-9258(18)33914-0","article-title":"Evidence that translocation of the glucose transport activity is the major mechanism of insulin action on glucose transport in fat cells","volume":"257","year":"1982","journal-title":"J. Biol. Chem."},{"key":"ref1901","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/stem.1573","article-title":"EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification","volume":"32","year":"2014","journal-title":"Stem. Cells"},{"key":"ref2771","doi-asserted-by":"crossref","first-page":"E77","DOI":"10.1152\/ajpendo.00380.2010","article-title":"Reducing selenoprotein P expression suppresses adipocyte differentiation as a result of increased preadipocyte inflammation","volume":"300","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref261","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1172\/JCI111075","article-title":"Influence of anatomic site and age on the replication and differentiation of rat adipocyte precursors in culture","volume":"72","year":"1983","journal-title":"J. Clin. Invest."},{"key":"ref941","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1258\/ebm.2010.010063","article-title":"Cell line models for differentiation: preadipocytes and adipocytes","volume":"235","year":"2010","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"ref2151","doi-asserted-by":"crossref","first-page":"734","DOI":"10.14348\/molcells.2014.0180","article-title":"The histone demethylase PHF2 promotes fat cell differentiation as an epigenetic activator of both C\/EBPa and C\/EBPd","volume":"37","year":"2014","journal-title":"Mol. Cells"},{"key":"ref761","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0531-5565(01)00135-8","article-title":"Oxidative modification of proteins during aging","volume":"36","year":"2001","journal-title":"Exp. Gerontol."},{"key":"ref2251","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/nm.2014","article-title":"A crucial role for adipose tissue p53 in the regulation of insulin resistance","volume":"15","year":"2009","journal-title":"Nat. Med."},{"key":"ref1811","doi-asserted-by":"crossref","first-page":"15504","DOI":"10.1074\/jbc.271.26.15504","article-title":"Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome","volume":"271","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref461","doi-asserted-by":"crossref","first-page":"10379","DOI":"10.1074\/jbc.M111.304998","article-title":"NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes","volume":"287","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref2131","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1210\/me.2011-1162","article-title":"Protein arginine methyltransferase 5 (Prmt5) promotes gene expression of peroxisome proliferator-activated receptor g2 (PPARg2) and its target genes during adipogenesis","volume":"26","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"ref1971","first-page":"149","article-title":"Differential redox potential profiles during adipogenesis and osteogenesis","volume":"16","year":"2011","journal-title":"Cell Mol. Biol. Lett."},{"key":"ref611","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","year":"2006","journal-title":"Nature"},{"key":"ref1021","first-page":"E281","article-title":"Effect of liposome-adipocyte interaction on hexose uptake and insulin action","volume":"241","year":"1981","journal-title":"Am. J. Physiol."},{"key":"ref2261","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.biochi.2012.12.014","article-title":"Oxidative stress and lipid peroxidation by-products at the crossroad between adipose organ dysregulation and obesity-linked insulin resistance","volume":"95","year":"2013","journal-title":"Biochimie"},{"key":"ref951","first-page":"29","article-title":"Ascorbic acid is a dose-dependent inhibitor of adipocyte differentiation, probably by reducing cAMP pool","volume":"2","year":"2014","journal-title":"Front Cell Dev. Biol."},{"key":"ref1441","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/47254","article-title":"Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension","volume":"402","year":"1999","journal-title":"Nature"},{"key":"ref2651","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bbalip.2009.12.006","article-title":"Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome\u2013an allostatic perspective","volume":"1801","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref1451","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref691","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.bbadis.2013.05.007","article-title":"Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis","volume":"1842","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/jcp.1132","article-title":"Rapamycin-sensitive phase of 3T3-L1 preadipocyte differentiation after clonal expansion","volume":"189","year":"2001","journal-title":"J. Cell Physiol."},{"key":"ref411","doi-asserted-by":"crossref","first-page":"15504","DOI":"10.1074\/jbc.271.26.15504","article-title":"Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome","volume":"271","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref1761","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/jcp.1132","article-title":"Rapamycin-sensitive phase of 3T3-L1 preadipocyte differentiation after clonal expansion","volume":"189","year":"2001","journal-title":"J. Cell Physiol."},{"key":"ref191","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3945\/ajcn.2009.27635","article-title":"Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults","volume":"90","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref621","doi-asserted-by":"crossref","first-page":"R1772","DOI":"10.1152\/ajpregu.2001.280.6.R1772","article-title":"Altered expression of C\/EBP family members results in decreased adipogenesis with aging","volume":"280","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref1191","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.cmet.2011.08.007","article-title":"Mitochondrial complex III ROS regulate adipocyte differentiation","volume":"14","year":"2011","journal-title":"Cell Metab."},{"key":"ref1061","doi-asserted-by":"crossref","first-page":"8735","DOI":"10.1074\/jbc.R113.544635","article-title":"Role of metabolic H2O2 generation: redox signaling and oxidative stress","volume":"289","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref2761","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1016\/j.febslet.2007.04.048","article-title":"The lipid peroxidation end-product 4-HNE induces COX-2 expression through p38MAPK activation in 3T3-L1 adipose cell","volume":"581","year":"2007","journal-title":"FEBS Lett."},{"key":"ref171","doi-asserted-by":"crossref","first-page":"E1466","DOI":"10.1210\/jc.2014-1074","article-title":"Adipocyte size threshold matters: link with risk of type 2 diabetes and improved insulin resistance after gastric bypass","volume":"99","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref1731","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1741-7007-7-38","article-title":"Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes","volume":"7","year":"2009","journal-title":"BMC Biol."},{"key":"ref1981","doi-asserted-by":"crossref","first-page":"e27401","DOI":"10.1371\/journal.pone.0027401","article-title":"Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes","volume":"6","year":"2011","journal-title":"PLoS One"},{"key":"ref2381","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1089\/ars.2010.3363","article-title":"Mitochondrial ROS generation and its regulation: mechanisms involved in H(2)O(2) signaling","volume":"14","year":"2011","journal-title":"Antioxid. Redox. Signal."},{"key":"ref1161","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.4161\/epi.29856","article-title":"Methylome, transcriptome, and PPAR(gamma) cistrome analyses reveal two epigenetic transitions in fat cells","volume":"9","year":"2014","journal-title":"Epigenetics"},{"key":"ref1131","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/ars.2013.5246","article-title":"Toward understanding success and failures in the use of selenium for cancer prevention","volume":"19","year":"2013","journal-title":"Antioxid. Redox. Signal."},{"key":"ref1421","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1172\/JCI37048","article-title":"Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans","volume":"119","year":"2009","journal-title":"J. Clin. Invest."},{"key":"ref2001","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.mam.2009.04.001","article-title":"The proteasomal system","volume":"30","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"ref1221","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3945\/jn.108.096131","article-title":"Tocotrienol suppresses adipocyte differentiation and Akt phosphorylation in 3T3-L1 preadipocytes","volume":"139","year":"2009","journal-title":"J. Nutr."},{"key":"ref1101","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1749-6632.2000.tb06187.x","article-title":"Protein oxidation","volume":"899","year":"2000","journal-title":"Ann. NY Acad. Sci."},{"key":"ref1861","doi-asserted-by":"crossref","first-page":"10379","DOI":"10.1074\/jbc.M111.304998","article-title":"NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes","volume":"287","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref541","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature04634","article-title":"Reactive oxygen species have a causal role in multiple forms of insulin resistance","volume":"440","year":"2006","journal-title":"Nature"},{"key":"ref1001","first-page":"E935","article-title":"Oxidant stress reduces insulin responsiveness in 3T3-L1 adipocytes","volume":"272","year":"1997","journal-title":"Am. J. Physiol."},{"key":"ref01","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nm0909-996","article-title":"Connecting obesity, aging and diabetes","volume":"15","year":"2009","journal-title":"Nat. Med."},{"key":"ref1471","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1021\/pr500324y","article-title":"Carbonylated plasma proteins as potential biomarkers of obesity induced type 2 diabetes mellitus","volume":"13","year":"2014","journal-title":"J. Proteome. Res."},{"key":"ref2211","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.1016\/S0021-9258(20)81883-3","article-title":"Induction of lipogenesis during differentiation in a \u201cpreadipocyte\u201d cell line","volume":"251","year":"1976","journal-title":"J. Biol. Chem."},{"key":"ref231","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2353\/ajpath.2009.081155","article-title":"Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations","volume":"175","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref721","first-page":"908539","article-title":"Oxidative stress and metabolic pathologies: from an adipocentric point of view","volume":"2014","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref2081","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0531-5565(02)00014-1","article-title":"Adipogenesis and aging: does aging make fat go MAD?","volume":"37","year":"2002","journal-title":"Exp. Gerontol."},{"key":"ref1281","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/febs.12096","article-title":"Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes","volume":"280","year":"2013a","journal-title":"FEBS J."},{"key":"ref711","doi-asserted-by":"crossref","first-page":"H2031","DOI":"10.1152\/ajpheart.01058.2004","article-title":"Adipokines: molecular links between obesity and atheroslcerosis","volume":"288","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref771","doi-asserted-by":"crossref","first-page":"10888","DOI":"10.1016\/S0021-9258(19)70390-1","article-title":"Effects of hydrogen peroxide on basal and hormone-stimulated lipolysis in perifused rat fat cells in relation to the mechanism of action of insulin","volume":"255","year":"1980","journal-title":"J. Biol. Chem."},{"key":"ref1741","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1038\/ncomms3262","article-title":"PPAR\u03b3-induced PARylation promotes local DNA demethylation by production of 5-hydroxymethylcytosine","volume":"4","year":"2013","journal-title":"Nat. Commun."},{"key":"ref831","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1128\/MCB.24.5.1844-1854.2004","article-title":"The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction","volume":"24","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"ref681","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0531-5565(02)00014-1","article-title":"Adipogenesis and aging: does aging make fat go MAD?","volume":"37","year":"2002","journal-title":"Exp. Gerontol."},{"key":"ref1561","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.envres.2015.03.020","article-title":"Serum selenium and lipid levels: Associations observed in the National Health and Nutrition Examination Survey (NHANES) 2011\u20132012","volume":"140","year":"2015","journal-title":"Environ. Res."},{"key":"ref1881","first-page":"24","article-title":"Aging and oxidative stress","volume":"10","year":"1998","journal-title":"J. Int. Fed. Clin. Chem."},{"key":"ref501","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/stem.1573","article-title":"EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification","volume":"32","year":"2014","journal-title":"Stem. Cells"},{"key":"ref2121","first-page":"908539","article-title":"Oxidative stress and metabolic pathologies: from an adipocentric point of view","volume":"2014","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref2461","doi-asserted-by":"crossref","first-page":"8735","DOI":"10.1074\/jbc.R113.544635","article-title":"Role of metabolic H2O2 generation: redox signaling and oxidative stress","volume":"289","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref801","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00125-006-0572-1","article-title":"Fat cell enlargement is an independent marker of insulin resistance and \u2018hyperleptinaemia\u2019","volume":"50","year":"2007","journal-title":"Diabetologia"},{"key":"ref1271","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/oby.2009.456","article-title":"Respiration in adipocytes is inhibited by reactive oxygen species","volume":"18","year":"2010b","journal-title":"Obesity (Silver Spring)"},{"key":"ref2021","doi-asserted-by":"crossref","first-page":"R1772","DOI":"10.1152\/ajpregu.2001.280.6.R1772","article-title":"Altered expression of C\/EBP family members results in decreased adipogenesis with aging","volume":"280","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref2101","doi-asserted-by":"crossref","first-page":"10942","DOI":"10.1016\/S0021-9258(18)33914-0","article-title":"Evidence that translocation of the glucose transport activity is the major mechanism of insulin action on glucose transport in fat cells","volume":"257","year":"1982","journal-title":"J. Biol. Chem."},{"key":"ref2391","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nrm2066","article-title":"Adipocyte differentiation from the inside out","volume":"7","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref531","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jprot.2013.01.004","article-title":"Protein oxidation in aging and the removal of oxidized proteins","volume":"92","year":"2013","journal-title":"J. Proteomics."},{"key":"ref2701","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12937-015-0007-2","article-title":"The association between dietary selenium intake and diabetes: a cross-sectional study among middle-aged and older adults","volume":"14","year":"2015","journal-title":"Nutr. J."},{"key":"ref1121","first-page":"40","article-title":"High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism","volume":"48","year":"2011","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref1401","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nm0909-996","article-title":"Connecting obesity, aging and diabetes","volume":"15","year":"2009","journal-title":"Nat. Med."},{"key":"ref2671","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/oby.2009.456","article-title":"Respiration in adipocytes is inhibited by reactive oxygen species","volume":"18","year":"2010b","journal-title":"Obesity (Silver Spring)"},{"key":"ref1921","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.freeradbiomed.2014.02.028","article-title":"Pathophysiological importance of aggregated damaged proteins","volume":"71","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref2401","first-page":"E935","article-title":"Oxidant stress reduces insulin responsiveness in 3T3-L1 adipocytes","volume":"272","year":"1997","journal-title":"Am. J. Physiol."},{"key":"ref151","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0014-5793(04)00112-7","article-title":"Redox regulation of PTEN and protein tyrosine phosphatases in H2O2 mediated cell signaling","volume":"560","year":"2004","journal-title":"FEBS Lett."},{"key":"ref2311","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1101\/gad.1089403","article-title":"Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2","volume":"17","year":"2003","journal-title":"Genes. Dev."},{"key":"ref2741","doi-asserted-by":"crossref","first-page":"10396","DOI":"10.1021\/ja4028346","article-title":"Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals","volume":"135","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref2271","doi-asserted-by":"crossref","first-page":"f10","DOI":"10.1136\/bmj.f10","article-title":"Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials","volume":"346","year":"2013","journal-title":"Br. Med. J."},{"key":"ref111","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.devcel.2010.02.018","article-title":"S6K1 plays a critical role in early adipocyte differentiation","volume":"18","year":"2010","journal-title":"Dev. Cell"},{"key":"ref891","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/sj.emboj.7600599","article-title":"Role of oxidative carbonylation in protein quality control and senescence","volume":"24","year":"2005","journal-title":"EMBO J."},{"key":"ref1721","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3945\/an.112.003319","article-title":"Protein carbonylation, mitochondrial dysfunction, and insulin resistance","volume":"4","year":"2013","journal-title":"Adv. Nutrition"},{"key":"ref2711","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","year":"2003","journal-title":"J. Clin. Invest."},{"key":"ref961","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.freeradbiomed.2010.12.006","article-title":"Oxidative stress, insulin signaling, and diabetes","volume":"50","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref1531","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.freeradbiomed.2012.06.005","article-title":"Carbonylation of the cytoskeletal protein actin leads to aggregate formation","volume":"53","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref2191","first-page":"490613","article-title":"Integrated haematological profiles of redox status, lipid, and inflammatory protein biomarkers in benign obesity and unhealthy obesity with metabolic syndrome","volume":"2015","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref581","doi-asserted-by":"crossref","first-page":"e27401","DOI":"10.1371\/journal.pone.0027401","article-title":"Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes","volume":"6","year":"2011","journal-title":"PLoS One"},{"key":"ref1821","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1096\/fasebj.11.7.9212076","article-title":"Degradation of oxidized proteins in mammalian cells","volume":"11","year":"1997","journal-title":"FASEB J."},{"key":"ref2061","doi-asserted-by":"crossref","first-page":"C206","DOI":"10.1152\/ajpcell.1990.258.2.C206","article-title":"Age, anatomic site, and the replication and differentiation of adipocyte precursors","volume":"258","year":"1990","journal-title":"Am. J. Physiol."},{"key":"ref1321","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1097-2765(00)80306-8","article-title":"Cross-regulation of C\/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity","volume":"3","year":"1999","journal-title":"Mol. Cell"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1093\/jn\/131.11.2892","article-title":"Dietary sesame seeds elevate a- and g-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil","volume":"131","year":"2001","journal-title":"J. Nutr."},{"key":"ref1461","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1001\/jama.2013.277028","article-title":"Antioxidant supplements to prevent mortality","volume":"310","year":"2013","journal-title":"J. Am. Med. Assoc."},{"key":"ref161","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.envres.2015.03.020","article-title":"Serum selenium and lipid levels: Associations observed in the National Health and Nutrition Examination Survey (NHANES) 2011\u20132012","volume":"140","year":"2015","journal-title":"Environ. Res."},{"key":"ref271","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/clpt.2012.149","article-title":"The genetic and epigenetic basis of type 2 diabetes and obesity","volume":"92","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref1251","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bbalip.2009.12.006","article-title":"Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome\u2013an allostatic perspective","volume":"1801","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref481","first-page":"24","article-title":"Aging and oxidative stress","volume":"10","year":"1998","journal-title":"J. Int. Fed. Clin. Chem."},{"key":"ref781","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cmet.2009.08.009","article-title":"Reactive oxygen species enhance insulin sensitivity","volume":"10","year":"2009","journal-title":"Cell Metab."},{"key":"ref751","doi-asserted-by":"crossref","first-page":"734","DOI":"10.14348\/molcells.2014.0180","article-title":"The histone demethylase PHF2 promotes fat cell differentiation as an epigenetic activator of both C\/EBPa and C\/EBPd","volume":"37","year":"2014","journal-title":"Mol. Cells"},{"key":"ref2371","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1042\/bj3350637","article-title":"Comparative resistance of the 20S and 26S proteasome to oxidative stress","volume":"335","year":"1998","journal-title":"Biochem. J."},{"key":"ref631","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.freeradbiomed.2012.05.039","article-title":"Chaperones, but not oxidized proteins, are ubiquitinated after oxidative stress","volume":"53","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref2161","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0531-5565(01)00135-8","article-title":"Oxidative modification of proteins during aging","volume":"36","year":"2001","journal-title":"Exp. Gerontol."},{"key":"ref2351","first-page":"29","article-title":"Ascorbic acid is a dose-dependent inhibitor of adipocyte differentiation, probably by reducing cAMP pool","volume":"2","year":"2014","journal-title":"Front Cell Dev. Biol."},{"key":"ref1541","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11010-014-2236-7","article-title":"Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects","volume":"399","year":"2015","journal-title":"Mol. Cell Biochem."},{"key":"ref1951","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1093\/jn\/131.11.2892","article-title":"Dietary sesame seeds elevate a- and g-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil","volume":"131","year":"2001","journal-title":"J. Nutr."},{"key":"ref2791","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.freeradbiomed.2013.07.012","article-title":"Selenium and diabetes\u2013evidence from animal studies","volume":"65","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref2321","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1371\/journal.pmed.0050051","article-title":"Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity","volume":"5","year":"2008","journal-title":"PLoS Med."},{"key":"ref2611","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nature02866","article-title":"Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity","volume":"431","year":"2004","journal-title":"Nature"},{"key":"ref1571","doi-asserted-by":"crossref","first-page":"E1466","DOI":"10.1210\/jc.2014-1074","article-title":"Adipocyte size threshold matters: link with risk of type 2 diabetes and improved insulin resistance after gastric bypass","volume":"99","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1172\/JCI37048","article-title":"Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans","volume":"119","year":"2009","journal-title":"J. Clin. Invest."},{"key":"ref1381","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.1128\/MCB.23.22.8137-8151.2003","article-title":"Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress","volume":"23","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"ref1671","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/clpt.2012.149","article-title":"The genetic and epigenetic basis of type 2 diabetes and obesity","volume":"92","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref211","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.freeradbiomed.2011.08.001","article-title":"Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress","volume":"51","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref861","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.biochi.2012.12.014","article-title":"Oxidative stress and lipid peroxidation by-products at the crossroad between adipose organ dysregulation and obesity-linked insulin resistance","volume":"95","year":"2013","journal-title":"Biochimie"},{"key":"ref2661","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1073\/pnas.1000031107","article-title":"Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis","volume":"107","year":"2010a","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref1711","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.2337\/diabetes.52.9.2346","article-title":"The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey","volume":"52","year":"2003","journal-title":"Diabetes"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.2337\/diabetes.52.9.2346","article-title":"The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey","volume":"52","year":"2003","journal-title":"Diabetes"},{"key":"ref731","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1210\/me.2011-1162","article-title":"Protein arginine methyltransferase 5 (Prmt5) promotes gene expression of peroxisome proliferator-activated receptor g2 (PPARg2) and its target genes during adipogenesis","volume":"26","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"ref1411","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/1474651411407558","article-title":"Dietary antioxidant interventions in type 2 diabetes patients: a meta-analysis","volume":"11","year":"2011","journal-title":"Br. J. Diabetes Vas. Dis."},{"key":"ref2451","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/emboj.2011.65","article-title":"Extensive chromatin remodelling and establishment of transcription factor \u2018hotspots\u2019 during early adipogenesis","volume":"30","year":"2011","journal-title":"EMBO J."},{"key":"ref1591","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3945\/ajcn.2009.27635","article-title":"Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults","volume":"90","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref2341","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1258\/ebm.2010.010063","article-title":"Cell line models for differentiation: preadipocytes and adipocytes","volume":"235","year":"2010","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.2337\/db09-1105","article-title":"Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction","volume":"59","year":"2010","journal-title":"Diabetes"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.freeradbiomed.2012.06.005","article-title":"Carbonylation of the cytoskeletal protein actin leads to aggregate formation","volume":"53","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/47254","article-title":"Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension","volume":"402","year":"1999","journal-title":"Nature"},{"key":"ref2731","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.2337\/db11-1716","article-title":"Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice","volume":"61","year":"2012","journal-title":"Diabetes"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1056\/NEJMoa1007487","article-title":"Perilipin deficiency and autosomal dominant partial lipodystrophy","volume":"364","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref2541","first-page":"948","article-title":"Adipose-cell size and immunoreactive insulin levels in obese and normal-weight adults","volume":"2","year":"1972","journal-title":"Lancet"},{"key":"ref561","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/109662004322984699","article-title":"Effects of tocopherols and tocotrienols on body composition and bone calcium content in adrenalectomized rats replaced with dexamethasone","volume":"7","year":"2004","journal-title":"J. Med. Food"},{"key":"ref2051","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1194\/jlr.M034603","article-title":"Dexamethasone-induced selenoprotein S degradation is required for adipogenesis","volume":"54","year":"2013","journal-title":"J. Lipid. Res."},{"key":"ref1961","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/109662004322984699","article-title":"Effects of tocopherols and tocotrienols on body composition and bone calcium content in adrenalectomized rats replaced with dexamethasone","volume":"7","year":"2004","journal-title":"J. Med. Food"},{"key":"ref2521","first-page":"40","article-title":"High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism","volume":"48","year":"2011","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref921","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1371\/journal.pmed.0050051","article-title":"Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity","volume":"5","year":"2008","journal-title":"PLoS Med."},{"key":"ref571","first-page":"149","article-title":"Differential redox potential profiles during adipogenesis and osteogenesis","volume":"16","year":"2011","journal-title":"Cell Mol. Biol. Lett."},{"key":"ref2691","first-page":"45","article-title":"Histone H3K9 methyltransferase G9a represses PPARgamma expression and adipogenesis","volume":"32","year":"2013b","journal-title":"EMBO J."},{"key":"ref301","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tem.2011.12.008","article-title":"Linking mitochondrial bioenergetics to insulin resistance via redox biology","volume":"23","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"ref1361","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1016\/j.febslet.2007.04.048","article-title":"The lipid peroxidation end-product 4-HNE induces COX-2 expression through p38MAPK activation in 3T3-L1 adipose cell","volume":"581","year":"2007","journal-title":"FEBS Lett."},{"key":"ref2531","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/ars.2013.5246","article-title":"Toward understanding success and failures in the use of selenium for cancer prevention","volume":"19","year":"2013","journal-title":"Antioxid. Redox. Signal."},{"key":"ref2241","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1016\/S0021-9258(17)30209-0","article-title":"Insulin-stimulated intracellular hydrogen peroxide production in rat epididymal fat cells","volume":"254","year":"1979","journal-title":"J. Biol. Chem."},{"key":"ref2291","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/sj.emboj.7600599","article-title":"Role of oxidative carbonylation in protein quality control and senescence","volume":"24","year":"2005","journal-title":"EMBO J."},{"key":"ref1631","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2353\/ajpath.2009.081155","article-title":"Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations","volume":"175","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref1831","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0006-291X(03)00809-X","article-title":"Selective degradation of oxidatively modified protein substrates by the proteasome","volume":"305","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref2221","doi-asserted-by":"crossref","first-page":"48662","DOI":"10.1074\/jbc.M105061200","article-title":"Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes","volume":"276","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref2681","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/febs.12096","article-title":"Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes","volume":"280","year":"2013a","journal-title":"FEBS J."},{"key":"ref2591","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.cmet.2011.08.007","article-title":"Mitochondrial complex III ROS regulate adipocyte differentiation","volume":"14","year":"2011","journal-title":"Cell Metab."},{"key":"ref821","doi-asserted-by":"crossref","first-page":"48662","DOI":"10.1074\/jbc.M105061200","article-title":"Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes","volume":"276","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref671","doi-asserted-by":"crossref","first-page":"B31","DOI":"10.1093\/geronj\/49.1.B31","article-title":"Effects of age and anatomic site on preadipocyte number in rat fat depots","volume":"49","year":"1994","journal-title":"J. Gerontol."},{"key":"ref2431","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/sj.emboj.7601623","article-title":"Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4","volume":"26","year":"2007","journal-title":"EMBO J."},{"key":"ref1801","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1074\/jbc.270.5.2344","article-title":"Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome","volume":"270","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref981","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1089\/ars.2010.3363","article-title":"Mitochondrial ROS generation and its regulation: mechanisms involved in H(2)O(2) signaling","volume":"14","year":"2011","journal-title":"Antioxid. Redox. Signal."},{"key":"ref1111","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.freeradbiomed.2013.07.016","article-title":"Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism","volume":"65","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref1771","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1056\/NEJMoa1007487","article-title":"Perilipin deficiency and autosomal dominant partial lipodystrophy","volume":"364","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref2281","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.2337\/db13-1459","article-title":"Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes","volume":"63","year":"2014","journal-title":"Diabetes"},{"key":"ref2471","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","year":"2015","journal-title":"Redox. Biol."},{"key":"ref421","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1096\/fasebj.11.7.9212076","article-title":"Degradation of oxidized proteins in mammalian cells","volume":"11","year":"1997","journal-title":"FASEB J."},{"key":"ref1641","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1089\/ars.2014.5939","article-title":"Proteasome dysfunction associated to oxidative stress and proteotoxicity in adipocytes compromises insulin sensitivity in human obesity","volume":"23","year":"2015","journal-title":"Antioxid. Redox. Signal."},{"key":"ref1611","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.freeradbiomed.2011.08.001","article-title":"Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress","volume":"51","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref881","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.2337\/db13-1459","article-title":"Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes","volume":"63","year":"2014","journal-title":"Diabetes"},{"key":"ref661","doi-asserted-by":"crossref","first-page":"C206","DOI":"10.1152\/ajpcell.1990.258.2.C206","article-title":"Age, anatomic site, and the replication and differentiation of adipocyte precursors","volume":"258","year":"1990","journal-title":"Am. J. Physiol."},{"key":"ref1371","doi-asserted-by":"crossref","first-page":"E77","DOI":"10.1152\/ajpendo.00380.2010","article-title":"Reducing selenoprotein P expression suppresses adipocyte differentiation as a result of increased preadipocyte inflammation","volume":"300","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref1931","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jprot.2013.01.004","article-title":"Protein oxidation in aging and the removal of oxidized proteins","volume":"92","year":"2013","journal-title":"J. Proteomics."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/1474651411407558","article-title":"Dietary antioxidant interventions in type 2 diabetes patients: a meta-analysis","volume":"11","year":"2011","journal-title":"Br. J. Diabetes Vas. Dis."},{"key":"ref1431","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-394625-6.00001-5","article-title":"The mitochondrial free radical theory of aging","volume":"127","year":"2014","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref1171","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.2337\/diabetes.51.7.2045","article-title":"Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes","volume":"51","year":"2002","journal-title":"Diabetes"},{"key":"ref1941","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature04634","article-title":"Reactive oxygen species have a causal role in multiple forms of insulin resistance","volume":"440","year":"2006","journal-title":"Nature"},{"key":"ref2111","doi-asserted-by":"crossref","first-page":"H2031","DOI":"10.1152\/ajpheart.01058.2004","article-title":"Adipokines: molecular links between obesity and atheroslcerosis","volume":"288","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref791","first-page":"490613","article-title":"Integrated haematological profiles of redox status, lipid, and inflammatory protein biomarkers in benign obesity and unhealthy obesity with metabolic syndrome","volume":"2015","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref201","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1471-4914(03)00031-5","article-title":"Protein carbonylation in human diseases","volume":"9","year":"2003","journal-title":"Trends Mol. Med."},{"key":"ref341","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1038\/ncomms3262","article-title":"PPAR\u03b3-induced PARylation promotes local DNA demethylation by production of 5-hydroxymethylcytosine","volume":"4","year":"2013","journal-title":"Nat. Commun."},{"key":"ref2361","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.freeradbiomed.2010.12.006","article-title":"Oxidative stress, insulin signaling, and diabetes","volume":"50","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref121","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0014-5793(03)00862-7","article-title":"Inhibition of preadipocyte proliferation by mitochondrial reactive oxygen species","volume":"550","year":"2003","journal-title":"FEBS Lett."},{"key":"ref1341","doi-asserted-by":"crossref","first-page":"10396","DOI":"10.1021\/ja4028346","article-title":"Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals","volume":"135","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref1651","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.freeradbiomed.2011.06.033","article-title":"Cross talk between mitochondria and NADPH oxidases","volume":"51","year":"2011","journal-title":"Free Radic. Biol. 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