{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:38:45Z","timestamp":1769834325710,"version":"3.49.0"},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2019-0102_s_999_w2aab2b8c51b1b7b1aab1c16b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Arterial stiffness is a consequence of aging, but there are several diseases that contribute to this process. The evaluation of pulse wave velocity (PWV) allows a dynamic evaluation of vascular distensibility and the detection of atherosclerosis at an early stage. It was intended to evaluate the PWV in children and adolescents with type 1 diabetes mellitus (T1DM) and to compare their outcome according to the type of treatment used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0102_s_998_w2aab2b8c51b1b7b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Forty-eight patients were randomly selected. Inclusion criteria: T1DM, under intensive insulin therapy (multiple daily insulin administrations [MDI] or continuous insulin infusion system [CIIS]). Exclusion criteria: existence of another chronic pathology or microvascular complications. Echocardiography was performed and three measurements of PWV were done, with their mean calculated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0102_s_997_w2aab2b8c51b1b7b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Most of the children and adolescents presented a PWV \u2265 the 75th centile. There was a statistically significant difference for hemoglobin A<jats:sub>1c<\/jats:sub> (HbA<jats:sub>1c<\/jats:sub>) (7.8 in CIIS vs. 9 in MDI, p\u2009&lt;\u20090.05). There were not statistically significant differences in the PWV between the two groups. This can be attributed to the fact that children with CIIS are those who previously presented greater glycemic instability. There was a significant correlation between PWV and disease duration (Pearson\u2019s correlation coefficient [r]\u2009=\u20090.314, p\u2009=\u20090.036).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2019-0102_s_996_w2aab2b8c51b1b7b1aab1c16b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study showed that in children and adolescents with T1DM, there is an important prevalence of arterial stiffness, translated by an increase in PWV. This increase in PWV appears to exist even in very young children with little disease evolution time.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2019-0102","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T21:10:50Z","timestamp":1561237850000},"page":"837-841","source":"Crossref","is-referenced-by-count":6,"title":["Arterial stiffness in children and adolescents with and without continuous insulin infusion"],"prefix":"10.1515","volume":"32","author":[{"given":"C\u00edntia","family":"Castro-Correia","sequence":"first","affiliation":[{"name":"Alameda Hern\u00e2ni Monteiro, Hospital S Jo\u00e3o, Servi\u00e7o de Pediatria , 4200 Porto , Portugal"},{"name":"Servi\u00e7o de Pediatria, Hospital Pedi\u00e1trico Integrado S Jo\u00e3o, Faculdade de Medicina da Universidade do Porto , Porto , Portugal"}]},{"given":"Cl\u00e1udia","family":"Moura","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Cardiologia Pedi\u00e1trica, Hospital Pedi\u00e1trico Integrado S Jo\u00e3o, Faculdade de Medicina da Universidade do Porto , Porto , Portugal"}]},{"given":"Cl\u00e1udia","family":"Mota","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Cardiologia Pedi\u00e1trica, Hospital Pedi\u00e1trico Integrado S Jo\u00e3o, Faculdade de Medicina da Universidade do Porto , Porto , Portugal"}]},{"given":"Rita","family":"Santos-Silva","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Pediatria, Hospital Pedi\u00e1trico Integrado S Jo\u00e3o, Faculdade de Medicina da Universidade do Porto , Porto , Portugal"}]},{"given":"J. Carlos","family":"Areias","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Cardiologia Pedi\u00e1trica, Hospital Pedi\u00e1trico Integrado S Jo\u00e3o, Faculdade de Medicina da Universidade do Porto , Porto , Portugal"}]},{"given":"Concei\u00e7\u00e3o","family":"Calhau","sequence":"additional","affiliation":[{"name":"CINTESIS, Center for Research in Health Technologies and Information Systems , Porto , Portugal"},{"name":"Nutrition and Metabolism, NOVA Medical School, FCM Universidade Nova de Lisboa , Lisbon , Portugal"}]},{"given":"Manuel","family":"Fontoura","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Pediatria, Hospital Pedi\u00e1trico Integrado S Jo\u00e3o, Faculdade de Medicina da Universidade do Porto , Porto , Portugal"}]}],"member":"374","published-online":{"date-parts":[[2019,6,22]]},"reference":[{"key":"2023040101054204870_j_jpem-2019-0102_ref_001_w2aab2b8c51b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Savant JD, Furth SL, Meyersa EC. 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