{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:49:03Z","timestamp":1747198143637,"version":"3.40.5"},"reference-count":55,"publisher":"Walter de Gruyter GmbH","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpem-2022-0593_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Premature adrenarche is often linked to a cluster of endocrine-metabolic risk factors. Our objective was to explore the association of dehydroepiandrosterone sulfate (DHEAS) levels at age 7 with cardio-metabolic traits at ages 10 and 13, independently of adiposity and pubertal stage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0593_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Longitudinal study of 603 individuals (301 girls\/302 boys) from the Generation XXI birth cohort. DHEAS at age 7 was measured by immunoassay. Anthropometrics, pubertal staging, blood pressure, and metabolic outcomes were evaluated at ages 7, 10, and 13. Pearson correlations between DHEAS and cardio-metabolic traits (insulin, HOMA-IR, triglycerides, LDL-cholesterol, high-sensitivity C-reactive protein, and systolic and diastolic blood pressure) were computed. Path analysis was used to estimate the effect of DHEAS at age 7 on cardiometabolic traits at ages 10 and 13, adjusted for body mass index (BMI) z-score and Tanner stage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0593_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>DHEAS at age 7 correlated positively with insulin and HOMA-IR at ages 7 and 10 in both sexes, and at age 13 in girls, but not in boys. In girls, DHEAS levels at age 7 directly influenced HOMA-IR at age 13, controlling for BMI and Tanner stage. In boys, DHEAS at age 7 did not influence HOMA-IR at ages 10 and 13. DHEAS at age 7 did not influence the other cardio-metabolic outcomes analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpem-2022-0593_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>DHEAS levels in mid-childhood have a positive longitudinal association with on insulin-resistance that persists, in girls, but not in boys, at least until age 13. No association was found regarding dyslipidemia, hypertension, or low-grade inflammation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpem-2022-0593","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T17:08:56Z","timestamp":1683220136000},"source":"Crossref","is-referenced-by-count":1,"title":["Dehydroepiandrosterone sulfate levels at 7 years old and cardio-metabolic factors at 10 and 13 years old\u00a0\u2013 the generation XXI birth cohort"],"prefix":"10.1515","volume":"0","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-3399","authenticated-orcid":false,"given":"Rita","family":"Santos-Silva","sequence":"first","affiliation":[{"name":"EPIUnit , Instituto de Sa\u00fade P\u00fablica, Universidade do Porto , Porto , Portugal"},{"name":"Unidade de Endocrinologia Pedi\u00e1trica , Servi\u00e7o de Pediatria, Centro Hospitalar Universit\u00e1rio de S. Jo\u00e3o , Porto , Portugal"},{"name":"Departamento de Ginecologia-Obstetr\u00edcia e Pediatria , Faculdade de Medicina, Universidade do Porto , Porto , Portugal"},{"name":"ITR\u00a0\u2013 Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional , Porto , Portugal"}]},{"given":"Manuel","family":"Fontoura","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia Pedi\u00e1trica , Servi\u00e7o de Pediatria, Centro Hospitalar Universit\u00e1rio de S. Jo\u00e3o , Porto , Portugal"},{"name":"Departamento de Ginecologia-Obstetr\u00edcia e Pediatria , Faculdade de Medicina, Universidade do Porto , Porto , Portugal"}]},{"given":"Milton","family":"Severo","sequence":"additional","affiliation":[{"name":"EPIUnit , Instituto de Sa\u00fade P\u00fablica, Universidade do Porto , Porto , Portugal"},{"name":"ITR\u00a0\u2013 Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional , Porto , Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica , Faculdade de Medicina, Universidade do Porto , Porto , Portugal"}]},{"given":"Ana Cristina","family":"Santos","sequence":"additional","affiliation":[{"name":"EPIUnit , Instituto de Sa\u00fade P\u00fablica, Universidade do Porto , Porto , Portugal"},{"name":"ITR\u00a0\u2013 Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional , Porto , Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica , Faculdade de Medicina, Universidade do Porto , Porto , Portugal"}]}],"member":"374","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"2023050417070117817_j_jpem-2022-0593_ref_001","doi-asserted-by":"crossref","unstructured":"Utriainen, P, Laakso, S, Liimatta, J, Jaaskelainen, J, Voutilainen, R. 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