{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:31:09Z","timestamp":1764102669002},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Aim:<\/jats:bold> To perform a systematic review to assess the accuracy of first-trimester ultrasound (US) in the diagnoses of major structural malformations in chromosomally normal fetuses.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> References were obtained from the MEDLINE database, without time range limitations. For each, the risk of bias was evaluated and the important data were extracted. Only studies that used first-trimester US to diagnose major structural malformations were included. We evaluated the sensitivity of US over a low-risk unselected population of pregnant women carrying euploid fetuses.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> A total of 19 studies were included, contributing to 126,937 fetuses and 1399 major malformations. The prevalence of lethal and severe malformations obtained was 1.2% [95% confidence interval (CI), 1.0\u20131.4]. Both averaged and pooled sensitivity, 50.0% (95% CI 44.1\u201355.9) and 45.2%, respectively, presented a moderate value for first-trimester US in the detection of structural malformations.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> Based on our analysis of the data, the average sensitivity of first-trimester US to detect structural malformations was 50%. It is our conviction that US has the potential to evolve in this role by exploiting the natural history of malformations and the development of US techniques.<\/jats:p>","DOI":"10.1515\/jpm-2013-0130","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T20:14:10Z","timestamp":1384200850000},"page":"141-149","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of the role of first-trimester obstetric ultrasound in the detection of major anomalies: a systematic review"],"prefix":"10.1515","volume":"42","author":[{"given":"S\u00edlvia","family":"Farraposo","sequence":"first","affiliation":[{"name":"Faculty of Medicine of University of Porto, Department of Obstetrics and Gynecology, Hospital S. Jo\u00e3o, Porto, Portugal"}]},{"given":"Nuno","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of University of Porto, Department of Obstetrics and Gynecology, Hospital S. Jo\u00e3o, Porto, Portugal"}]},{"given":"Alexandra","family":"Matias","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of University of Porto, Department of Obstetrics and Gynecology, Hospital S. Jo\u00e3o, Porto, Portugal"}]}],"member":"374","published-online":{"date-parts":[[2013,11,9]]},"container-title":["Journal of Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0130\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0130\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T03:25:35Z","timestamp":1678764335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpm-2013-0130\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,9]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,11,21]]},"published-print":{"date-parts":[[2014,3,1]]}},"alternative-id":["10.1515\/jpm-2013-0130"],"URL":"https:\/\/doi.org\/10.1515\/jpm-2013-0130","relation":{},"ISSN":["1619-3997","0300-5577"],"issn-type":[{"value":"1619-3997","type":"electronic"},{"value":"0300-5577","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11,9]]}}}