{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:01:33Z","timestamp":1777932093044,"version":"3.51.4"},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2017-0132_s_999_w2aab3b7b9b1b6b1aab1c16b1Aa\">\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare levels of \u03b2-hCG and estradiol collected during the first trimester in singleton and twin pregnancies following assisted reproduction technologies (ART).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2017-0132_s_998_w2aab3b7b9b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We prospectively evaluated 50 singleton and 47 dichorionic twin pregnancies that eventually ended in live births. Patients were recruited from a single ART center with standard treatment protocols followed by fresh embryo transfers. Hormone measurements were performed within a narrow gestational age range and analyzed in a single laboratory thus minimizing inter- and intra-assay variability. We measured serum \u03b2-hCG at 13 days after embryo transfer as well as samples of \u03b2-hCG and estradiol at 8\u20139 weeks+6 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2017-0132_s_997_w2aab3b7b9b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>No significant differences existed between singletons and twins in respect to demographic and cycle characteristics. \u03b2-hCG and estradiol were all significantly higher in twins (P&lt;0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2017-0132_s_996_w2aab3b7b9b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The data confirms the higher levels of \u03b2-hCG and estradiol in twins, pointing to the potential role of these placental hormones in early support of a twin pregnancy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2017-0132","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T10:07:53Z","timestamp":1501236473000},"page":"853-856","source":"Crossref","is-referenced-by-count":16,"title":["First trimester \u03b2-hCG and estradiol levels in singleton and twin pregnancies after assisted reproduction"],"prefix":"10.1515","volume":"46","author":[{"given":"Ana","family":"P\u00f3voa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , Unit of Reproductive Medicine, Hospitalar Center S\u00e3o Jo\u00e3o, Alameda Prof. Hern\u00e2ni Monteiro , 4200-319 Porto , Portugal"}]},{"given":"Pedro","family":"Xavier","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Unit of Reproductive Medicine, Hospitalar Center S\u00e3o Jo\u00e3o, Alameda Prof. Hern\u00e2ni Monteiro , 4200-319 Porto , Portugal"}]},{"given":"Alexandra","family":"Matias","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Faculty of Medicine, University of Porto\/Hospitalar Center S. Jo\u00e3o, Alameda Prof. Hern\u00e2ni Monteiro , 4200-319 Porto , Portugal"},{"name":"I3S Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade , Universidade do Porto , Porto , Portugal"}]},{"given":"Isaac","family":"Blickstein","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Kaplan Medical Center , Rehovot , Israel"},{"name":"The Hadassah-Hebrew University School of Medicine , Jerusalem , Israel"}]}],"member":"374","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"2021021318312047565_j_jpm-2017-0132_ref_001_w2aab3b7b9b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Sunderam S, Kissin DM, Crawford S, Anderson JE, Folger SG, Jamieson DJ, et al. Assisted reproductive technology surveillance \u2013 United States, 2012. 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