{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:49:38Z","timestamp":1777978178295,"version":"3.51.4"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jpm-2018-0163_s_999_w2aab3b7c74b1b6b1aab1c15b1Aa\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The ductus venosus agenesis (DVA) is a rare condition with a variable prognosis that relies partly on the presence of associated conditions. The purpose of our study was to analyze the literature regarding the post-natal outcome of fetuses with DVA associated with fetal malformations, in order to discuss the best management options for couples.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0163_s_998_w2aab3b7c74b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a systematic review of the literature of MEDLINE and SCOPUS electronic databases in a 25-year period from 1992 to September 2017.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0163_s_997_w2aab3b7c74b1b6b1aab1c15b3Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We found 340 cases of DVA associated with fetal abnormalities. The most common chromosomal abnormalities were: monosomy X (12\/48, 25%), trisomy 21 (11\/48, 22.9%) and trisomy 18 (6\/48, 12.5%). From the 340 cases with DVA, in 31 cases the umbilical venous shunt type was not reported. Of the fetuses, 60.8% (188\/309) had an extrahepatic umbilical venous drainage while 39.2% (121\/309) presented an intrahepatic connection. The DVA was associated in 71 cases (23.0%) with cardiac abnormalities, in 82 cases (26.5%) with extracardiac abnormalities and in 85 cases (27.5%) with both cardiac and extracardiac abnormalities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jpm-2018-0163_s_996_w2aab3b7c74b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>DVA associated with both cardiac and extracardiac malformations may confer a poorer fetal outcome, a clinically relevant fact that should clarify what can be expected from this entity and help prenatal counseling.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jpm-2018-0163","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T05:50:10Z","timestamp":1531461010000},"page":"1-11","source":"Crossref","is-referenced-by-count":29,"title":["Ductus venosus agenesis and fetal malformations: what can we expect? \u2013 a systematic review of the literature"],"prefix":"10.1515","volume":"47","author":[{"given":"Diana","family":"Pacheco","sequence":"first","affiliation":[{"name":"Faculty of Medicine , University of Porto , Porto , Portugal , Tel.: +351938619352"},{"name":"Hospital S. Jo\u00e3o, Alameda Professor Hern\u00e2ni Monteiro , 4200-319 Porto , Portugal"}]},{"given":"Ot\u00edlia","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centro Hospitalar de S. Jo\u00e3o , Porto , Portugal"}]},{"given":"Nuno","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Centro Hospitalar de S. Jo\u00e3o, Faculty of Medicine, EPIUnit , University of Porto , Porto , Portugal"}]},{"given":"Alexandra","family":"Matias","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Centro Hospitalar de S. Jo\u00e3o, Faculty of Medicine , University of Porto , Porto , Portugal"}]}],"member":"374","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"2021021321162037539_j_jpm-2018-0163_ref_001_w2aab3b7c74b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Kiserud T, Acharya G. The fetal circulation. Prenat Diagn 2004;24:1049\u201359.","DOI":"10.1002\/pd.1062"},{"key":"2021021321162037539_j_jpm-2018-0163_ref_002_w2aab3b7c74b1b6b1ab2b1b2Aa","unstructured":"Mende D. Lnsertionis venae umbilicalis in partem atrii cordis dextri anteriorem, unius vero arteriae umbilicalis, ex aorta abdominali prorumpentis, in foetu masculo maturo ac neonato: singularem casum. Nova acta physico-medica Academiae Caesareae Leopoldino-Carolinae Naturae Curiosum 1826; 869\u201374."},{"key":"2021021321162037539_j_jpm-2018-0163_ref_003_w2aab3b7c74b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Staboulidou I, Pereira S, Cruz Jde J, Syngelaki A, Nicolaides KH. Prevalence and outcome of absence of ductus venosus at 11(+0) to 13(+6) weeks. 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Twin Res 2000;3:65\u201370."},{"key":"2021021321162037539_j_jpm-2018-0163_ref_023_w2aab3b7c74b1b6b1ab2b1c23Aa","doi-asserted-by":"crossref","unstructured":"Wiechec M, Nocun A, Matyszkiewicz A, Wiercinska E, Lata\u0142a E. First trimester severe ductus venosus flow abnormalities in isolation or combination with other markers of aneuploidy and fetal anomalies. J Perinat Med 2016;44:201\u20139.","DOI":"10.1515\/jpm-2014-0323"},{"key":"2021021321162037539_j_jpm-2018-0163_ref_024_w2aab3b7c74b1b6b1ab2b1c24Aa","doi-asserted-by":"crossref","unstructured":"Volpe P, Marasini M, Caruso G, Lituania M, Marzullo A, Volpe G, et al. Prenatal diagnosis of ductus venosus agenesis and its association with cytogenetic\/congenital anomalies. Prenat Diagn 2002;22:995\u20131000.","DOI":"10.1002\/pd.456"},{"key":"2021021321162037539_j_jpm-2018-0163_ref_025_w2aab3b7c74b1b6b1ab2b1c25Aa","doi-asserted-by":"crossref","unstructured":"Rudolph CD, Meyers RL, Paulick RP, Rudolph AM. 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