{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T06:41:18Z","timestamp":1656312078691},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The enthalpies of solution of alcohols were determined by calorimetry in HEPES and (HEPES + trehalose) at 298.15 K. The used methodology and experiment\u2019s design allowed us to extract from a single titration experiment the enthalpy of solution (\u0394<jats:sub>sol<\/jats:sub>\n                  <jats:italic>H<\/jats:italic>\n                  <jats:sub>m<\/jats:sub>), the limiting solubility of the alcohol in each aqueous media, and an estimation of the enthalpy of solution of water in the alcohol phase. From these values the changes in Gibbs energy (\u0394<jats:sub>sol<\/jats:sub>\n                  <jats:italic>G<\/jats:italic>\n                  <jats:sub>m<\/jats:sub>) and in entropy (\u0394<jats:sub>sol<\/jats:sub>\n                  <jats:italic>S<\/jats:italic>\n                  <jats:sub>m<\/jats:sub>) of solution were derived. A decrease in solubility for 1-butanol and 1-pentanol in the crowded media (HEPES + trehalose) was observed which is driven by a significant decrease in the favorable enthalpy of solution. The partial molar heat capacity, <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/j_pac-2014-5014_fig_001.jpg\" \/> in each media was determined in our heat capacity drop calorimeter, also at 298.15 K. A significant decrease of the partial molar heat capacity was observed for both alcohols in (HEPES + trehalose), which together with the obtained decrease in favorable \u0394<jats:sub>sol<\/jats:sub>\n                  <jats:italic>H<\/jats:italic>\n                  <jats:sub>m<\/jats:sub>, is consistent with a decrease in hydrophobic solvation, as a result of a decrease in free solvent availability induced by the trehalose. Finally, we tentatively predict that in the aqueous media of the crowded solutions that characterize cells and biological fluids, solutes with low aqueous solubility will be more soluble, whereas the solubility of highly polar solutes will be reduced.<\/jats:p>","DOI":"10.1515\/pac-2014-5014","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T08:51:12Z","timestamp":1395046272000},"page":"223-231","source":"Crossref","is-referenced-by-count":2,"title":["Enthalpies of solution, limiting solubilities, and partial molar heat capacities of n-alcohols in water and in trehalose crowded media"],"prefix":"10.1515","volume":"86","author":[{"given":"Guangyue","family":"Bai","sequence":"first","affiliation":[{"name":"CIQ (UP), Faculty of Sciences, Department of Chemistry and Biochemistry, University of Porto, R. Campo Alegre, 687, P-4169-007 Porto, Portugal"},{"name":"School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, China"}]},{"given":"Sandra C.C.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Coimbra Chemistry Center, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"given":"Marisa A.A.","family":"Rocha","sequence":"additional","affiliation":[{"name":"CIQ (UP), Faculty of Sciences, Department of Chemistry and Biochemistry, University of Porto, R. Campo Alegre, 687, P-4169-007 Porto, Portugal"}]},{"given":"Lu\u00eds M.N.B.F.","family":"Santos","sequence":"additional","affiliation":[{"name":"CIQ (UP), Faculty of Sciences, Department of Chemistry and Biochemistry, University of Porto, R. Campo Alegre, 687, P-4169-007 Porto, Portugal"}]},{"given":"M. Ermelinda S.","family":"Eus\u00e9bio","sequence":"additional","affiliation":[{"name":"Coimbra Chemistry Center, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"given":"M. Jo\u00e3o","family":"Moreno","sequence":"additional","affiliation":[{"name":"Coimbra Chemistry Center, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"given":"Margarida","family":"Bastos","sequence":"additional","affiliation":[{"name":"CIQ (UP), Faculty of Sciences, Department of Chemistry and Biochemistry, University of Porto, R. Campo Alegre, 687, P-4169-007 Porto, Portugal"}]}],"member":"374","published-online":{"date-parts":[[2014,1,17]]},"reference":[{"key":"2022062615015064161_j_pac-2014-5014_ref_001","doi-asserted-by":"crossref","unstructured":"M. Bastos, T. Kimura, I. Wads\u00f6. J. Chem. Thermodynamics23, 1069 (1991).","DOI":"10.1016\/S0021-9614(05)80112-0"},{"key":"2022062615015064161_j_pac-2014-5014_ref_002","unstructured":"M. Bastos, S.-O. 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