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Molecular dynamics simulations are presented which indicate both the viability of this mechanism for folding and its limitations in the presence of a Markovian thermal bath. An analysis of a set of protein structures formed only of helices and loops suggests that bending sites are correlated with regions bounded, on the N-side, by positively charged amino acids like Lysine and Histidine and on the C-side by negatively charged amino acids like Aspartic acid.<\/jats:p>","DOI":"10.1515\/pac-2019-0301","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T09:01:38Z","timestamp":1577437298000},"page":"179-191","source":"Crossref","is-referenced-by-count":3,"title":["The VES KM: a pathway for protein folding in vivo"],"prefix":"10.1515","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7958-6435","authenticated-orcid":false,"given":"Leonor","family":"Cruzeiro","sequence":"first","affiliation":[{"name":"CCMAR and Physics, FCT, Universidade do Algarve , Campus de Gambelas , 8005-139 Faro , Portugal"}]}],"member":"374","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"key":"2023040102514270154_j_pac-2019-0301_ref_001","doi-asserted-by":"crossref","unstructured":"P. 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