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Because they are substances with narrow therapeutic windows, and since they are capable of interacting with other classes of compounds, monitoring of these compounds is of relevance, minimizing the risk of medical interactions as well as side and toxic effects. In addition, understanding the extent of their use, their detection through routine toxicology tests and development of new methods for detection and monitoring is of extreme importance concerning public health, patient well-being, and implications in clinical and forensic situations. The main objective of this work is to perform a critical review on the biological samples used in the detection and quantification of antidepressants with special focus on the techniques for sample preparation.<\/jats:p>","DOI":"10.1515\/revac-2021-0124","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T02:24:14Z","timestamp":1617589454000},"page":"12-32","source":"Crossref","is-referenced-by-count":15,"title":["A review of current bioanalytical approaches in sample pretreatment techniques for the determination of antidepressants in biological specimens"],"prefix":"10.1515","volume":"40","author":[{"given":"Sofia","family":"Soares","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI) , Universidade da Beira Interior , Covilh\u00e3 , Portugal ; Laborat\u00f3rio de F\u00e1rmaco-Toxicologia \u2013 UBIMedical , Universidade da Beira Interior , Covilh\u00e3 , Portugal"}]},{"given":"M\u00e1rio","family":"Barroso","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Qu\u00edmica e Toxicologia Forenses, Instituto Nacional de Medicina Legal e Ci\u00eancias Forenses , Delega\u00e7\u00e3o do Sul , Lisboa , Portugal"}]},{"given":"Eugenia","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI) , Universidade da Beira Interior , Av. Infante D. Henrique , , Covilh\u00e3 , Portugal ; Laborat\u00f3rio de F\u00e1rmaco-Toxicologia \u2013 UBIMedical , Universidade da Beira Interior , Covilh\u00e3 , Portugal"}]}],"member":"374","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"2025120909534361361_j_revac-2021-0124_ref_001","unstructured":"World Health Organization. New WHO guidelines to improve the physical health of people with severe mental disorders [Internet]. World Health Organization; 2018. Available from: https:\/\/www.who.int\/mental_health\/en\/"},{"key":"2025120909534361361_j_revac-2021-0124_ref_002","doi-asserted-by":"crossref","unstructured":"Spielmans GI, Berman MI, Linardatos E, Rosenlicht NZ, Perry A, Tsai AC. Adjunctive atypical antipsychotic treatment for major depressive disorder: a meta-analysis of depression, quality of life, and safety outcomes. 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