{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:32:19Z","timestamp":1787164339950,"version":"build-2736575974"},"reference-count":75,"publisher":"Informa UK Limited","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1517\/13543770903270532","type":"journal-article","created":{"date-parts":[[2009,9,10]],"date-time":"2009-09-10T09:51:22Z","timestamp":1252576282000},"page":"1535-1580","source":"Crossref","is-referenced-by-count":31,"title":["Novel factor Xa inhibitors: a patent review"],"prefix":"10.1517","volume":"19","author":[{"given":"Modesto","family":"de Candia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Lopopolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Altomare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2009,9,10]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nature06797","volume":"451","author":"Mackman N","year":"2008","journal-title":"Nature"},{"key":"CIT0002","unstructured":"World Health Organization. Atlas of Heart Disease and Stroke. World Health Organization, Geneva, Switzerland; 2004"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000264509.36234.51"},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1517\/13543784.16.3.271","volume":"16","author":"Weitz JI","year":"2007","journal-title":"Expert Opin Investig Drugs"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S1367-5931(00)00112-5","volume":"4","author":"Vacca JP","year":"2000","journal-title":"Curr Opin Chem Biol"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1055\/s-0029-1145260","volume":"34","author":"Harenberg J","year":"2008","journal-title":"Semin Thromb Hemost"},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1124\/jpet.106.117952","volume":"322","author":"Krynetskly E","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01352.x"},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1056\/NEJMcp052967","volume":"355","author":"Arepally GM","year":"2006","journal-title":"N Engl J Med"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02011.x"},{"issue":"1","key":"CIT0012","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1538-7836.2007.02499.x","volume":"5","author":"Eikelboom JW","year":"2007","journal-title":"J Thromb Haemost"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.jacc.2004.05.084","volume":"44","author":"P\u00e9rez-G\u00f3mez F","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/CIRCULATIONAHA.106.655910","volume":"116","author":"Schneider DJ","year":"2007","journal-title":"Circulation"},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1021\/jm048984g","volume":"48","author":"Anderluh P\u0160","year":"2005","journal-title":"J Med Chem"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1021\/jm801141f","volume":"52","author":"de Candia M","year":"2009","journal-title":"J Med Chem"},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.2174\/0929867043364540","volume":"11","author":"Steinmettzer T","year":"2004","journal-title":"Curr Med Chem"},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.2174\/1381612033453901","volume":"9","author":"Gould WR","year":"2003","journal-title":"Curr Pharm Des"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200528040-00006"},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1021\/jm0109513","volume":"45","author":"Hauel NH","year":"2002","journal-title":"J Med Chem"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(07)61445-7","volume":"370","author":"Eriksson BI","year":"2007","journal-title":"Lancet"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrd2622","volume":"7","author":"Eriksson BI","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/1568026013395380","volume":"1","author":"Leadley RJ","year":"2001","journal-title":"Curr Top Med Chem"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev.med.56.082103.104708","volume":"56","author":"Linkins L-A","year":"2005","journal-title":"Annu Rev Med"},{"key":"CIT0025","first-page":"460","volume":"7","author":"Quan ML","year":"2004","journal-title":"Curr Opin Drug Discov Dev"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2174\/1568026013395461","volume":"1","author":"Maignan S","year":"2001","journal-title":"Curr Top Med Chem"},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1517\/13543776.9.7.931","volume":"9","author":"Al-Obeidi F","year":"1999","journal-title":"Expert Opin Ther Patents"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1021\/jm020578e","volume":"46","author":"Lam PY","year":"2003","journal-title":"J Med Chem"},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1517\/13543776.16.2.119","volume":"16","author":"Casimiro-Garcia A","year":"2006","journal-title":"Expert Opin Ther Patents"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1021\/jm00034a018","volume":"37","author":"Nagahara T","year":"1994","journal-title":"J Med Chem"},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/S0960-894X(02)00213-5","volume":"12","author":"Guertin KR","year":"2002","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1021\/jm000409z","volume":"44","author":"Pinto DJ","year":"2001","journal-title":"J Med Chem"},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1527-3466.2002.tb00188.x","volume":"20","author":"Wong PC","year":"2002","journal-title":"Cardiovasc Drug Rev"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1021\/jm0497949","volume":"48","author":"Quan MI","year":"2005","journal-title":"J Med Chem"},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"5900","DOI":"10.1021\/jm050101d","volume":"48","author":"Roherig S","year":"2005","journal-title":"J Med Chem"},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.1021\/jm070245n","volume":"50","author":"Pinto DJ","year":"2007","journal-title":"J Med Chem"},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1021\/jm0203837","volume":"46","author":"Maignan S","year":"2003","journal-title":"J Med Chem"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1021\/jm0490540"},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1021\/jm049187l","volume":"48","author":"Matter H","year":"2005","journal-title":"J Med Chem"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1021\/jm070125f"},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/j.bmcl.2004.03.036","volume":"14","author":"Haginoya N","year":"2004","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrd2851","volume":"8","author":"Melnikoca I","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"CIT0043","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1160\/TH06-09-0539","volume":"97","author":"Fisher WD","year":"2007","journal-title":"Thromb Haemost"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802361499"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200847030-00006"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02764.x"},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1111\/j.1538-7836.2008.03064.x","volume":"6","author":"Furugohri T","year":"2008","journal-title":"J Thromb Haemost"},{"key":"CIT0050","first-page":"778","volume":"8","author":"Hylek E","year":"2007","journal-title":"Curr Opin Investig Drugs"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1160\/TH07-04-0312","volume":"98","author":"Zafar MU","year":"2007","journal-title":"Thromb Hemost"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.2165\/0003088-200948010-00001"},{"key":"CIT0054","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.2174\/156802605775009702","volume":"5","author":"Saiah E","year":"2005","journal-title":"Curr Top Med Chem"},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1016\/S0968-0896(02)00106-2","volume":"10","author":"Hirayama F","year":"2002","journal-title":"Bioorg Med Chem"},{"key":"CIT0058","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/cmdc.200700031","volume":"2","author":"St\u00fcrzebecher A","year":"2007","journal-title":"ChemMedChem"},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1016\/j.bmcl.2007.03.105","volume":"17","author":"D\u00f6nnecke D","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0063","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/j.1538-7836.2006.01793.x","volume":"4","author":"Rossi C","year":"2006","journal-title":"J Thromb Haemost"},{"key":"CIT0065","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1021\/jm701217r","volume":"51","author":"Lee Y-K","year":"2008","journal-title":"J Med Chem"},{"key":"CIT0104","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.1016\/j.bmcl.2007.06.029","volume":"17","author":"Qiao JX","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0105","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1016\/j.bmcl.2007.07.020","volume":"17","author":"Qiao JX","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0109","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1016\/j.ejmech.2008.12.025","volume":"44","author":"Groebke Zbinden K","year":"2009","journal-title":"Eur J Med Chem"},{"key":"CIT0116","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1016\/j.bmcl.2008.03.092","volume":"18","author":"Corte JR","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0118","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1016\/j.bmcl.2006.04.044","volume":"16","author":"Fevig JM","year":"2006","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0119","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1016\/j.bmcl.2006.02.069","volume":"16","author":"Pinto DJP","year":"2006","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0124","doi-asserted-by":"crossref","first-page":"5584","DOI":"10.1016\/j.bmcl.2006.08.027","volume":"16","author":"Pinto DJP","year":"2006","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0125","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.bmcl.2006.11.071","volume":"17","author":"Qiao JX","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0126","first-page":"1020","volume":"9","author":"Shantsila E","year":"2008","journal-title":"Curr Opin Invest Drugs"},{"key":"CIT0127","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1160\/TH08-07-0486","volume":"101","author":"Jiang X","year":"2009","journal-title":"Thromb Haemost"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02939.x"},{"key":"CIT0135","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/j.bmcl.2009.02.111","volume":"19","author":"Zhang P","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0136","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1016\/j.bmcl.2009.02.114","volume":"19","author":"Zhang P","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0143","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1021\/jm060870c","volume":"50","author":"Chan C","year":"2007","journal-title":"J Med Chem"},{"key":"CIT0144","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1016\/j.bmcl.2007.03.080","volume":"17","author":"Young RJ","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0152","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.bmc.2005.09.056","volume":"14","author":"Komoriya S","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"CIT0153","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1016\/j.bmcl.2007.05.068","volume":"17","author":"Nagata T","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0173","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1747-0285.2007.00520.x","volume":"69","author":"Van Huis CA","year":"2007","journal-title":"Chem Biol Drug Des"},{"key":"CIT0181","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1248\/cpb.54.1535","volume":"54","author":"Saitoh F","year":"2006","journal-title":"Chem Pharm Bull"},{"key":"CIT0182","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1248\/cpb.55.317","volume":"55","author":"Saitoh F","year":"2007","journal-title":"Chem Pharm Bull"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/13543770903270532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T08:01:22Z","timestamp":1710576082000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/13543770903270532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,10]]},"references-count":75,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2009,10,26]]},"published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1517\/13543770903270532"],"URL":"https:\/\/doi.org\/10.1517\/13543770903270532","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,10]]}}}