{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:34:46Z","timestamp":1782513286896,"version":"3.54.5"},"reference-count":78,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1517\/13543776.16.2.189","type":"journal-article","created":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T15:55:21Z","timestamp":1138118121000},"page":"189-200","source":"Crossref","is-referenced-by-count":19,"title":["Antimetabolites and cancer: emerging data with a focus on antifolates"],"prefix":"10.1517","volume":"16","author":[{"given":"Giorgio V","family":"Scagliotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Selvaggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2006,1,24]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1056\/NEJM194806032382301","volume":"238","author":"FARBER","year":"1948","journal-title":"N. Engl. J. Med."},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1517\/14622416.5.7.819","volume":"5","author":"KRAJINOVIC","year":"2004","journal-title":"Pharmacogenomics"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"8470","DOI":"10.1016\/S0021-9258(19)38912-4","volume":"265","author":"CHU","year":"1990","journal-title":"J. Biol. Chem."},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0022-3565(24)36936-8","volume":"282","author":"FISKERSTRAND","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0005","first-page":"13","volume":"225","author":"PHILIPS","year":"2004","journal-title":"Sci."},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1073\/pnas.0408107102","volume":"102","author":"WINTER-VANN","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"CIT0007","unstructured":"CHU E, MOTA AC, FOGARASI MC: Antimetabolites. In:CANCER. Principles and practice of oncology.De Vita Jr VT, Hellmann S, Rosenberg SA (Eds), Lippincott W&W, Philadelphia, USA (2001):388-415."},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1039\/b503664j","volume":"3","author":"WEI","year":"2005","journal-title":"Org. Biomol. Chem."},{"key":"CIT0009","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0925-4439(02)00079-0","volume":"1587","author":"BANERJEE","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/(SICI)1098-1004(1998)11:4<259::AID-HUMU1>3.0.CO;2-W","volume":"11","author":"BLAKLEY","year":"1998","journal-title":"Hum. Mutat."},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/09674845.2003.11783687","volume":"60","author":"BOSSON","year":"2003","journal-title":"Br. J. Biomed. Sci."},{"key":"CIT0012","first-page":"4599","volume":"61","author":"COLE","year":"2001","journal-title":"Cancer Res."},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ng1215","volume":"34","author":"ALBERTSON","year":"2003","journal-title":"Nat. Genet."},{"key":"CIT0014","doi-asserted-by":"crossref","unstructured":"MORALES C, RIBAS M, AIZA G, PEINADO MA: Genetic determinants of methotrexate responsiveness and resistance in colon cancer cells.Oncogene(2005) Epub ahead of print.","DOI":"10.1038\/sj.onc.1208834"},{"key":"CIT0015","first-page":"609","volume":"47","author":"LIN","year":"1987","journal-title":"Cancer Res."},{"key":"CIT0016","first-page":"156","volume":"3","author":"BENNET","year":"1995","journal-title":"Clin. Perform Qual. Health Care"},{"key":"CIT0017","first-page":"649","volume":"9","author":"TAKIMOTO","year":"1995","journal-title":"Oncology"},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/01.coc.0000054903.27866.31","volume":"27","author":"MACHIAVELLI","year":"2004","journal-title":"Am. J. Clin. Oncol."},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/bjc.1998.423","volume":"77","author":"BLACKLEDGE","year":"1998","journal-title":"Br. J. Cancer"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00668-8"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.123"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"6881","DOI":"10.1200\/JCO.20005.14.589","volume":"23","author":"VAN MEERBECK","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/0959-8049(95)00502-1","volume":"31","author":"CUNNINGHAM","year":"1995","journal-title":"Eur. J. Cancer"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1200\/JCO.1998.16.9.2943","volume":"16","author":"COCCONI","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"CIT0025","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0959-8049(02)00005-9","volume":"38","author":"FELIU","year":"2002","journal-title":"Eur. J. Cancer"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.3816\/CLC.2004.s.003","author":"ADJEI","year":"2004","journal-title":"Clin. Lung Cancer"},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1586\/14737140.3.2.145","volume":"3","author":"ADJEI","year":"2003","journal-title":"Expert Rev. Anticancer Ther."},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1158\/1078-0432.1294.11.3","volume":"11","author":"ZHAO","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1158\/0008-5472.CAN-03-3953","volume":"64","author":"ZHAO","year":"2004","journal-title":"Cancer Res."},{"key":"CIT0030","first-page":"545","volume":"1","author":"NIYIKIZA","year":"2002","journal-title":"Mol. Cancer Ther."},{"key":"CIT0031","first-page":"3235","volume":"18","author":"WORZALLA","year":"1998","journal-title":"Anti-Cancer Res."},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1124\/mol.104.009373","volume":"68","author":"GIOVANNETTI","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","volume":"21","author":"VOGELZANG","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1200\/JCO.2004.08.163","volume":"22","author":"HANNA","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.06.122"},{"key":"CIT0036","unstructured":"PACKAGE INSERT: Alimta (pemetrexed). Indianapolis, IN, USA. Eli Lilly, (August 2004)."},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1124\/jpet.105.090043","volume":"5","author":"DAI","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2005.n.016"},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/annonc\/mdf115","volume":"13","author":"CLARKE","year":"2002","journal-title":"Ann. Oncol."},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1200\/JCO.1999.17.4.1194","volume":"17","author":"RUSTHOVEN","year":"1999","journal-title":"J. Clin. Oncol."},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/1097-0142(20010801)92:3<595::AID-CNCR1359>3.0.CO;2-D","volume":"92","author":"SHEPHERD","year":"2001","journal-title":"Cancer"},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1023\/A:1008336931378","volume":"11","author":"MANEGOLD","year":"2000","journal-title":"Ann. Oncol."},{"key":"CIT0043","first-page":"483","volume":"25","author":"BAYES","year":"2003","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"CIT0044","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s002800050823","volume":"42","author":"SIROTNAK","year":"1998","journal-title":"Cancer Chemother. Pharmacol."},{"key":"CIT0045","first-page":"2072","volume":"9","author":"KRUG","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"CIT0046","first-page":"3199","volume":"7","author":"KHOKHAR","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"CIT0047","first-page":"1","volume":"31","author":"FURY","year":"2005","journal-title":"Cancer Chemother. Pharmacol."},{"key":"CIT0048","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1470-2045(02)00788-X","volume":"3","author":"GALMARINI","year":"2002","journal-title":"Lancet Oncol."},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1002\/cncr.21005","volume":"103","author":"FADERL","year":"2005","journal-title":"Cancer"},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1038\/nrd1729","volume":"4","author":"PUI","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"CIT0051","first-page":"3","volume":"23","author":"PLUNKETT","year":"1996","journal-title":"Semin. Oncol."},{"key":"CIT0052","first-page":"4417","volume":"50","author":"HERTEL","year":"1990","journal-title":"Cancer Res."},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970715)80:2<286::AID-CNCR17>3.0.CO;2-Q"},{"key":"CIT0054","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00280-004-0869-z","volume":"55","author":"DE CASTRO","year":"2005","journal-title":"Cancer Chemother. Pharmacol."},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1349-7006.2004.tb03189.x","volume":"95","author":"MATSUDA","year":"2004","journal-title":"Cancer Sci."},{"key":"CIT0056","first-page":"273","volume":"8","author":"KOIZUMI","year":"2001","journal-title":"Int. J. Mol. Med."},{"key":"CIT0057","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1349-7006.2005.00046.x","volume":"96","author":"KAZUNO","year":"2005","journal-title":"Cancer Sci."},{"key":"CIT0058","first-page":"2289","volume":"5","author":"LAMONT","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1200\/JCO.2005.17.749","volume":"23","author":"KELLY","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"CIT0060","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1200\/JCO.1998.16.1.301","volume":"16","author":"META-ANALYSIS","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"CIT0061","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1200\/JCO.2004.03.104","volume":"22","author":"THIRION","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.10.017"},{"key":"CIT0063","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1046\/j.1365-2125.1996.34212.x","volume":"41","author":"MCMURROUGH","year":"1996","journal-title":"Br. J. Clin. Pharmacol."},{"key":"CIT0064","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1517\/14656566.6.7.1231","volume":"6","author":"MCKENDRICK","year":"2005","journal-title":"Expert Opin. Pharmacother."},{"key":"CIT0065","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1200\/JCO.2001.19.21.4097","volume":"19","author":"VAN CUTSEM","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"CIT0066","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0006-2952(98)00318-9","volume":"57","author":"BERGMAN","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"CIT0067","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1368-7646(02)00002-X","volume":"5","author":"BERGMAN","year":"2002","journal-title":"Drug Resist Update"},{"key":"CIT0068","doi-asserted-by":"crossref","first-page":"9510","DOI":"10.1158\/0008-5472.CAN-05-0989","volume":"65","author":"BERGMAN","year":"2005","journal-title":"Cancer Res."},{"key":"CIT0069","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1158\/1535-7163.MCT-05-0121","volume":"4","author":"JORDHEIM","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"CIT0070","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1200\/JCO.2005.19.752","volume":"23","author":"ALLEN","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"CIT0071","first-page":"4306","volume":"52","author":"JOHNSTON","year":"1992","journal-title":"Cancer Res."},{"key":"CIT0072","first-page":"1227","volume":"4","author":"LENZ","year":"1998","journal-title":"Clin. Cancer Res."},{"key":"CIT0073","first-page":"1322","volume":"6","author":"SALONGA","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"CIT0074","first-page":"792","volume":"9","author":"FARRUGIA","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"CIT0075","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1038\/nrd1731","volume":"4","author":"GIBBS","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"CIT0076","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1067\/mtc.2001.111176","volume":"121","author":"BUENO","year":"2001","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"CIT0077","unstructured":"EC 2.7.1.48"},{"key":"CIT0078","unstructured":"GENBANK AF236637"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/13543776.16.2.189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T10:49:54Z","timestamp":1736246994000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/13543776.16.2.189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,24]]},"references-count":78,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,1,24]]},"published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1517\/13543776.16.2.189"],"URL":"https:\/\/doi.org\/10.1517\/13543776.16.2.189","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,24]]}}}