{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:24:08Z","timestamp":1783038248830,"version":"3.54.6"},"reference-count":51,"publisher":"Informa UK Limited","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1517\/13543776.2011.593511","type":"journal-article","created":{"date-parts":[[2011,6,25]],"date-time":"2011-06-25T09:00:37Z","timestamp":1308992437000},"page":"1433-1451","source":"Crossref","is-referenced-by-count":38,"title":["Farnesyl pyrophosphate synthase modulators: a patent review (2006 \u2013 2010)"],"prefix":"10.1517","volume":"21","author":[{"given":"Shuting","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2011,6,25]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1021\/cr9600464","volume":"98","author":"Ogura K","year":"1998","journal-title":"Chem Rev"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.03014.x"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"45","DOI":"10.18388\/abp.2005_3485","volume":"52","author":"Szkopinska A","year":"2005","journal-title":"Acta Biochim Pol"},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1126\/science.277.5333.1788","volume":"277","author":"Sacchettini JC","year":"1997","journal-title":"Science"},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s11745-004-1233-3","volume":"39","author":"Holstein SA","year":"2004","journal-title":"Lipids"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/ange.19590712102","volume":"71","author":"Lynen F","year":"1959","journal-title":"Angew Chem Int Ed"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"6562","DOI":"10.1021\/bi900371p","volume":"48","author":"Liang PH","year":"2009","journal-title":"Biochemistry"},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/153537020422900701","volume":"229","author":"Mo H","year":"2004","journal-title":"Exp Biol Med (Maywood)"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.12.3.253"},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"526","DOI":"10.2174\/187152009788451860","volume":"9","author":"Wiemer AJ","year":"2009","journal-title":"Anticancer Agents Med Chem"},{"issue":"10","key":"CIT0011","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.2174\/156802610793176602","author":"Wiemer AJ","year":"2010","journal-title":"Curr Top Med Chem"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1006\/bbrc.1999.1499","volume":"264","author":"van Beek E","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1073\/pnas.0601643103","volume":"103","author":"Kavanagh KL","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1359\/jbmr.2000.15.8.1467","volume":"15","author":"Coxon FP","year":"2000","journal-title":"J Bone Miner Res"},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0022-3565(24)38786-5","volume":"296","author":"Dunford JE","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"8526","DOI":"10.1074\/jbc.C300511200","volume":"279","author":"Hosfield DJ","year":"2004","journal-title":"J Biol Chem"},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/cmdc.200500059","volume":"1","author":"Rondeau JM","year":"2006","journal-title":"ChemMedChem"},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00198-007-0540-8","volume":"19","author":"Russell RGG","year":"2008","journal-title":"Osteoporos Int"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.2174\/138161210793563635"},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.2174\/138161210793563617","volume":"16","author":"Dunford JE","year":"2010","journal-title":"Curr Pharm Des"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2011.02.058"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1006\/bbrc.1999.1404","volume":"263","author":"Martin MB","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.2174\/092986711794088335"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1016\/j.jorganchem.2005.03.005","volume":"690","author":"Ebetino FH","year":"2005","journal-title":"J Organomet Chem"},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1021\/ja808285e","volume":"131","author":"Zhang YH","year":"2009","journal-title":"J Am Chem Soc"},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1021\/jm00050a010","volume":"37","author":"Klebe G","year":"1994","journal-title":"J Med Chem"},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1021\/jm0302344","volume":"46","author":"Sanders JM","year":"2003","journal-title":"J Med Chem"},{"key":"CIT0038","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1021\/jm010412y","volume":"45","author":"Szabo CM","year":"2002","journal-title":"J Med Chem"},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"10022","DOI":"10.1073\/pnas.0702254104","volume":"104","author":"Guo RT","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"CIT0045","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1021\/jm0702884","volume":"50","author":"Marma MS","year":"2007","journal-title":"J Med Chem"},{"key":"CIT0047","first-page":"139","volume-title":"Bisphosphonates on Bones","author":"Ebetino FH","year":"1995"},{"key":"CIT0048","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/j.bmcl.2008.03.088","volume":"18","author":"Deprele S","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1021\/jm7015733","volume":"51","author":"Dunford JE","year":"2008","journal-title":"J Med Chem"},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1021\/jm900232u","volume":"53","author":"McKenna CE","year":"2010","journal-title":"J Med Chem"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"48213","DOI":"10.1074\/jbc.M106473200","volume":"276","author":"Coxon FP","year":"2001","journal-title":"J Biol Chem"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bone.2005.04.021","volume":"37","author":"Coxon FP","year":"2005","journal-title":"Bone"},{"key":"CIT0053","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.1074\/jbc.M806952200","volume":"284","author":"Baron RA","year":"2009","journal-title":"J Biol Chem"},{"key":"CIT0054","author":"Blazewska KM","journal-title":"Eur J Med Chem"},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1038\/emboj.2008.164","volume":"27","author":"Guo Z","year":"2008","journal-title":"EMBO J"},{"key":"CIT0056","doi-asserted-by":"crossref","first-page":"8025","DOI":"10.1021\/jm901117d","volume":"52","author":"Tan KT","year":"2009","journal-title":"J Med Chem"},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nchembio.421","volume":"6","author":"Jahnke W","year":"2010","journal-title":"Nat Chem Biol"},{"key":"CIT0062","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00217308","volume":"238","author":"van Rooijen N","year":"1984","journal-title":"Cell Tissue Res"},{"key":"CIT0063","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1002\/eji.1830271023","volume":"27","author":"Seiler P","year":"1997","journal-title":"Eur J Immunol"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg374"},{"key":"CIT0073","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2165\/00003495-200666050-00011","volume":"66","author":"McCormack PL","year":"2006","journal-title":"Drugs"},{"key":"CIT0074","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2165\/00003495-200767050-00011","volume":"67","author":"Keating GM","year":"2007","journal-title":"Drugs"},{"key":"CIT0075","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2174\/092986707779941096","volume":"14","author":"Linares GE","year":"2007","journal-title":"Curr Med Chem"},{"key":"CIT0082","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1021\/bc800369c","volume":"19","author":"Kashemirov BA","year":"2008","journal-title":"Bioconjug Chem"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1080\/10426507.2010.526674"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.091009"},{"key":"CIT0087","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bone.2011.03.774","volume":"49","author":"Ebetino FH","year":"2011","journal-title":"Bone"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/13543776.2011.593511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T17:07:44Z","timestamp":1741280864000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/13543776.2011.593511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,25]]},"references-count":51,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,8,16]]},"published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1517\/13543776.2011.593511"],"URL":"https:\/\/doi.org\/10.1517\/13543776.2011.593511","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,25]]}}}