{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:50:27Z","timestamp":1761540627560},"reference-count":106,"publisher":"Informa Healthcare","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2003,5]]},"DOI":"10.1517\/13543784.12.5.781","type":"journal-article","created":{"date-parts":[[2005,5,4]],"date-time":"2005-05-04T20:54:02Z","timestamp":1115240042000},"page":"781-797","source":"Crossref","is-referenced-by-count":35,"title":["New antithrombotic drugs on the horizon"],"prefix":"10.1517","volume":"12","author":[{"given":"Johannes","family":"Ruef","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo A","family":"Katus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3197","published-online":{"date-parts":[[2005,3,2]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07493-4"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7329.71"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-000-0049-7"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1021\/bi00107a001"},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1055\/s-0037-1616529","volume":"86","author":"MUTCH NJ","year":"2001","journal-title":"Thromb. Haemost."},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-200301000-00004"},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1055\/s-0038-1646193","volume":"70","author":"VLASUK GP","year":"1993","journal-title":"Thromb. Haemost."},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"9718","DOI":"10.1016\/S0021-9258(18)47993-8","volume":"262","author":"TUSZYNSKI GP","year":"1987","journal-title":"Biol Chem."},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012160703533"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1023\/A:1019802310702"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200109000-00016"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.22.2658"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-1738(02)00174-3"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252643299"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(83)90550-8"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011100"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08648-8"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.22.2726"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.11.3.397"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1182\/blood.V91.11.4197","volume":"91","author":"HERBERT JM","year":"1998","journal-title":"Blood"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200301000-00011"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1055\/s-0037-1613122","volume":"87","author":"HERAULT JP","year":"2002","journal-title":"Thromb. Haemost."},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1055\/s-0037-1612979","volume":"87","author":"HERAULT JP","year":"2002","journal-title":"Thromb. Haemost."},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.9.7.1595"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1080\/004982500237514"},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1055\/s-0037-1613294","volume":"88","author":"SHIMBO D","year":"2002","journal-title":"Thromb. Haemost."},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016351.12759.52"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1021\/jm000409z"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2002.tb00188.x"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(01)00328-0"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704182"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(00)00227-9"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.2174\/1568026013395498"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1159\/000056154"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(02)00024-5"},{"key":"CIT0049","first-page":"212","volume":"295","author":"WONG PC","year":"2000","journal-title":"Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis.' Pharmacol. Exp. Ther."},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2583.2002.00375.x"},{"key":"CIT0052","first-page":"1187","volume":"50","author":"NISHIDA H","year":"2002","journal-title":"Substituent effect on biological activities. Chem. Pharm. Bull."},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(01)00418-7"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(00)00458-3"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00942-0"},{"key":"CIT0056","first-page":"457377","author":"WATERWORTH C","year":"2002","journal-title":"IDdb..? Report"},{"key":"CIT0057","first-page":"1","volume":"1806","author":"The IDdb reference report","year":"2002","journal-title":"Pharma Japan"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(02)00921-6"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1053\/shem.2002.34092"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1002421"},{"key":"CIT0061","first-page":"751","volume":"57","author":"HAUPTMANN J","year":"2002","journal-title":"A review of small-molecule thrombin inhibitors. Eui: I Clin. Pharmacol."},{"key":"CIT0063","first-page":"57","volume":"57","author":"GLYNN","year":"2003","journal-title":"hat. Gin. Piaci"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11469-3"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(02)00259-1"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1021\/jm990557t"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1021\/jm0109513"},{"key":"CIT0069","first-page":"905","volume":"3","author":"MUNGALL D","year":"2002","journal-title":"Carr. Opin. Investig. Drugs"},{"key":"CIT0070","first-page":"263572","author":"BUCKLE DR","year":"1997","journal-title":"IDdb..? Report"},{"key":"CIT0071","first-page":"453507","author":"KAKKAR S","year":"2002","journal-title":"SMI Conference - Advances in Hypertension and Cardiovascular Therapeutics. IDdb..? Report"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008900109285"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026555510258"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(99)00219-4"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1021\/jm011110z"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1021\/jm9705014"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(02)00585-1"},{"key":"CIT0084","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1055\/s-0037-1614128","volume":"84","author":"FRIEDERICH PW","year":"2000","journal-title":"Thromb. Haemost."},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4892(01)00031-5"},{"key":"CIT0087","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1055\/s-0038-1657572","volume":"78","author":"BAJAJ MS","year":"1997","journal-title":"Thromb. Haemost."},{"key":"CIT0090","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1055\/s-0038-1650632","volume":"76","author":"KAMIKUBO Y","year":"1996","journal-title":"Thromb. Haemost."},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01018-4"},{"key":"CIT0092","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1055\/s-0037-1613025","volume":"87","author":"YANG J","year":"2002","journal-title":"Thromb. Haemost."},{"key":"CIT0093","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1055\/s-0037-1615608","volume":"85","author":"HIMBER J","year":"2001","journal-title":"Thromb. Haemost."},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1038\/35006574"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1021\/bi010591l"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00781.x"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202507200"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1161\/hc2601.091386"},{"key":"CIT0103","first-page":"415130","author":"SO L","year":"2001","journal-title":"IDdb Report"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011955018052"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021445"},{"key":"CIT0108","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1055\/s-0038-1650371","volume":"75","author":"CHARLTON PA","year":"1996","journal-title":"Thromb. Haemost."},{"key":"CIT0109","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1055\/s-0037-1616758","volume":"86","author":"RUPIN A","year":"2001","journal-title":"Thromb. Haemost."},{"key":"CIT0110","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1055\/s-0037-1614900","volume":"82","author":"MOHRI M","year":"1999","journal-title":"Thromb. Haemost."},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1053\/shem.2002.34093"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.9.3235"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(01)00314-0"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1177\/107602960100700210"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04080.x"},{"issue":"36","key":"CIT0122","first-page":"1620\u2013","volume":"2002","author":"HOWARD PA","year":"1624","journal-title":"Ann. Pharmacother"},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(01)00353-X"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.10.2303"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01590-X"},{"key":"CIT0129","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1055\/s-0037-1614136","volume":"84","author":"GUREVITZ","year":"2000","journal-title":"Thromb. Haemost."},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.4.459"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703761"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016703.93845.AF"},{"key":"CIT0133","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00313-4"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)00733-6"},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12257"},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.1038\/nm760"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00514-4"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00223-5"},{"key":"CIT0139","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039341.57809.1E"},{"key":"CIT0140","doi-asserted-by":"publisher","DOI":"10.1159\/000139506"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01885-X"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1177\/107602960100700303"},{"key":"CIT0145","first-page":"E17\u2013E20","volume":"80","author":"PATRONO C","year":"1997","journal-title":"Am. Cardial"},{"key":"CIT0146","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09409-6"},{"key":"CIT0147","doi-asserted-by":"publisher","DOI":"10.1345\/aph.10079"},{"key":"CIT0148","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.7.2.299"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/13543784.12.5.781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T15:26:09Z","timestamp":1625930769000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/13543784.12.5.781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":106,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2005,3,2]]},"published-print":{"date-parts":[[2003,5]]}},"alternative-id":["10.1517\/13543784.12.5.781"],"URL":"https:\/\/doi.org\/10.1517\/13543784.12.5.781","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5]]}}}