{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:18:41Z","timestamp":1761196721095},"reference-count":83,"publisher":"Informa Healthcare","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1517\/13543784.15.8.833","type":"journal-article","created":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T13:52:58Z","timestamp":1153489978000},"page":"833-842","source":"Crossref","is-referenced-by-count":12,"title":["Investigational agents for sickle cell disease"],"prefix":"10.1517","volume":"15","author":[{"given":"Iheanyi","family":"Okpala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3197","published-online":{"date-parts":[[2006,7,21]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1038\/180326a0"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1002\/9780470988398.ch3"},{"key":"CIT0003","author":"UNESCO","year":"2005","journal-title":"General Conference, 33rd Session"},{"key":"CIT0004","first-page":"118","volume":"7","author":"KONOTEY-AHULU","year":"1968","journal-title":"Ghana Med. J."},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90524-X"},{"key":"CIT0006","unstructured":"AFRICANUS HORTON JB: The diseases of tropical climates and their treatment. Churchill, London, UK (1874)."},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1910.00050330050003"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2005.08.004"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17192-4"},{"key":"CIT0010","first-page":"15","volume":"34","author":"CHARACHE","year":"1997","journal-title":"Semin. Hematol."},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200316672"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1182\/blood.V89.7.2554","volume":"89","author":"STYLES","year":"1997","journal-title":"Blood"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02040.x"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.13.1645"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197304192881601"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb24158.x"},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1182\/blood.V91.9.3423","volume":"91","author":"MOLLAPOUR","year":"1998","journal-title":"Blood"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1998.tb01036.x"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1738"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05332.x"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"666a","DOI":"10.1182\/blood.V106.11.2347.2347","volume":"106","author":"ABDULMALIK","year":"2005","journal-title":"Blood"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1021\/jm0498001"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1182\/blood.V77.6.1334.1334","volume":"77","author":"ABRAHAM","year":"1991","journal-title":"Blood"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1984.tb10775.x"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90941-4"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1021\/jf00017a016"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-393X(01)80039-4"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03593.x"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04536.x"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00040"},{"key":"CIT0031","author":"XECHEM","year":"2004","journal-title":"27th Annual Meeting of National Sickle Cell Program"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.1998.0759"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0713"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.17.7538"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000190108.62414.06"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2005.08.002"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.9.3356"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(03)00037-7"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.02775.x"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0196"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1080\/mic.11.2.129.151"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01150.2003"},{"key":"CIT0043","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1182\/blood.V96.7.2451","volume":"96","author":"BELCHER","year":"2000","journal-title":"Blood"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00367-8"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1955"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2329"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00052.2003"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(01)90023-X"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117149"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1433"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"33a","DOI":"10.1182\/blood.V104.11.1665.1665","volume":"104","author":"ATAGA","year":"2004","journal-title":"Blood"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000219658.57915.d4"},{"key":"CIT0053","first-page":"298","volume":"3","author":"PUTHENVEETIL","year":"2004","journal-title":"Curr. Hematol. Rep."},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200103000-00001"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04143.x"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065806"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1122"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302243"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(01)90055-1"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3652"},{"key":"CIT0061","doi-asserted-by":"crossref","first-page":"243a","DOI":"10.1182\/blood.V106.11.243.243","volume":"106","author":"CABANTCHIK","year":"2005","journal-title":"Blood"},{"key":"CIT0062","doi-asserted-by":"crossref","first-page":"242a","DOI":"10.1182\/blood.V106.11.823.823","volume":"106","author":"BRISSOT","year":"2005","journal-title":"Blood"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2386"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199911000-00013"},{"key":"CIT0065","first-page":"1591","volume":"8","author":"LUE","year":"2002","journal-title":"Campbell\u2019s Urology"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03691.x"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2005.08.003"},{"key":"CIT0068","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S0022-5347(17)41904-5","volume":"140","author":"WINTER","year":"1988","journal-title":"J. Urol."},{"key":"CIT0069","author":"DRUGDEX","year":"2004","journal-title":"Thompson MICROMEDEX"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(96)00027-1"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1136\/adc.85.1.52"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2002.03022.x"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1002\/9780470988398.ch14"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2005.07.007"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70401-9"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.03.034"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20238"},{"key":"CIT0078","author":"ONYEKWERE","year":"2005","journal-title":"28th Annual Meeting of the National Sickle Cell Program"},{"key":"CIT0079","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/02724936.2000.11748143","volume":"20","author":"WALI","year":"2000","journal-title":"Ann. Trop. Paediatr."},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1981.00340070071015"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1989.00390020137029"},{"key":"CIT0082","first-page":"120","author":"EL-BESHLAWY","year":"1999","journal-title":"Abstract Book of the 25th Meeting of the International Society of Haematology-African & European Division"},{"key":"CIT0083","first-page":"452a","volume":"100","author":"MORRIS","year":"2002","journal-title":"Blood"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/13543784.15.8.833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T03:55:20Z","timestamp":1627617320000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/13543784.15.8.833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,21]]},"references-count":83,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2006,7,21]]},"published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1517\/13543784.15.8.833"],"URL":"https:\/\/doi.org\/10.1517\/13543784.15.8.833","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,21]]}}}