{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:22:35Z","timestamp":1790407355488,"version":"4.1.0"},"reference-count":86,"publisher":"Informa UK Limited","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1517\/13543784.2010.510513","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T11:57:17Z","timestamp":1281614237000},"page":"1147-1159","source":"Crossref","is-referenced-by-count":13,"title":["Investigational agents for Crohn's disease"],"prefix":"10.1517","volume":"19","author":[{"given":"Mario","family":"Cottone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambrogio","family":"Orlando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Renna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2010,8,12]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.03.014"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.02.001"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03681.x"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804647"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800710821"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040725"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20174"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90687-8"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00868.x"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.111872"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20602"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70013-2"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007056"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02942.x"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0157-y"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.07.016"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00171-9"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.9370"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20377"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0171-0"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68265-2"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91024-2"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1038\/35079107"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2009.08.011"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00661-9"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.11.1591"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1038\/ng2061"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1038\/ng.483"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041109"},{"issue":"2","key":"CIT0030","first-page":"A 103","volume":"132","author":"Feagan BG","year":"2007","journal-title":"Gastroenterology"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.165738"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0029-7"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.4049\/jimmunol.136.7.2348","volume":"136","author":"Mosmann TR","year":"1986","journal-title":"J Immunol"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20212"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.163667"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9247454"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.1.42"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5483.1352"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.03.028"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70550-0"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01179.x"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00356.x"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.012"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.09.058"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033402"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1097\/01.ibd.0000225337.14356.31"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.07.014"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02024.x"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.079434"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.079392"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21038"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03778.x"},{"key":"CIT0054","unstructured":"Abbas A, Lichtman A, Pillai S. Cellular and molecular immunolology. 6th edition. Elsevier; 2007"},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.4049\/jimmunol.163.7.4049","volume":"163","author":"Liu Z","year":"1999","journal-title":"J Immunol"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02526.x"},{"issue":"4","key":"CIT0057","first-page":"CD007277","author":"Maxwell L","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.26260"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020732"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043335"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.024"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20014"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.06.007"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70418-4"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01341.x"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.1.30"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.11.001"},{"key":"CIT0068","first-page":"OP-G-93","volume":"22","author":"Keshav S","year":"2006","journal-title":"Gut"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.30770"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2005.11.013"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1002\/art.27348"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1517\/14622416.5.5.479"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.024"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710093371502"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905063401804"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.030"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.106781"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.06.064"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067594"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02285.x"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08512-4"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030815"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.051"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.106781"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.041"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062897"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70332-X"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/13543784.2010.510513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T11:22:54Z","timestamp":1711711374000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/13543784.2010.510513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,12]]},"references-count":86,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2010,8,26]]},"published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1517\/13543784.2010.510513"],"URL":"https:\/\/doi.org\/10.1517\/13543784.2010.510513","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,12]]}}}