{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:11:28Z","timestamp":1761513088429},"reference-count":81,"publisher":"Informa Healthcare","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1517\/13543784.2012.655422","type":"journal-article","created":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T16:00:36Z","timestamp":1328112036000},"page":"265-279","source":"Crossref","is-referenced-by-count":11,"title":["A novel vaginal microbicide containing the rationally designed anti-HIV compound HI-443 (<i>N<\/i>\u2032-[2-(2-thiophene)ethyl]-<i>N<\/i>\u2032-[2-(5-bromopyridyl)] thiourea])"],"prefix":"10.1517","volume":"21","author":[{"given":"Osmond J","family":"D'Cruz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjive","family":"Qazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seang","family":"Yiv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih M","family":"Uckun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3197","published-online":{"date-parts":[[2012,2]]},"reference":[{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1038\/nri2302"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-009-0004-1"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1038\/nature08757"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-080709-124959"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/5.5.506"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki464"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.59.061206.112737"},{"key":"CIT0010","first-page":"152","volume":"9","author":"D'Cruz OJ","year":"2008","journal-title":"Curr Opin Investig Drugs"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193748"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31802bb35f"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043386374"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200001070-00010"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001474"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003784"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5538"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61842-5"},{"key":"CIT0019","first-page":"66","volume-title":"Digital comprehensive summaries of Uppsala dissertations from the Faculty of Science and Technology 834","author":"Elinder M","year":"2011"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1080\/14756360600774413"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.2174\/157016206777709519"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200303280-00002"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1021\/bi970140u"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1128\/JVI.71.4.3023-3030.1997","volume":"71","author":"Borkow G","year":"1997","journal-title":"J Virol"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1089\/088922202760072339"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.9.4440-4446.2006"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah236"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015835"},{"issue":"1","key":"CIT0029","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/095632020101200103","volume":"12","author":"Pani A","year":"2001","journal-title":"Antivir Chem Chemother"},{"key":"CIT0030","first-page":"199","volume":"306","author":"Cole AM","year":"2006","journal-title":"Curr Top Microbiol Immunol"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2011.01.005"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.029603"},{"issue":"142","key":"CIT0033","first-page":"392","volume":"2","author":"Weber J","year":"2005","journal-title":"PLoS Med"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.4.1509-1520.2005"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.7.2336"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200302140-00005"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2004.04.010"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2007.07.004"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318159d5a8"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0200085"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1995.0077"},{"key":"CIT0043","first-page":"404","volume":"53","author":"Noguchi K","year":"2003","journal-title":"Comp Med"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199804010-00006"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200522574"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2008.0184"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1021\/jm960802y"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.337-339.2004"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200307250-00003"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181e3293a"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01426-10"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01096-08"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015835"},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1128\/AAC.42.12.3225","volume":"42","author":"Sudbeck EA","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1177\/095632029901000502"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(99)00235-8"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(99)00624-1"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00408-1"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1021\/jm00025a010"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100362"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1021\/jm950639r"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1107\/S0108270199012044"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.8.5633"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40111399.x"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1086\/432916"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.2.181"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013552"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1086\/378280"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20599"},{"key":"CIT0071","first-page":"278","volume":"57","author":"Uckun FM","year":"2007","journal-title":"Arzneimittelforschung"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2005.07.004"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.2174\/187221109789105658"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.04.028"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1208\/pt060111"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.032870"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.01.131"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.10.001"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1080\/01926230590959866"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21077"},{"key":"CIT0081","first-page":"483","volume":"57","author":"Uckun FM","year":"2007","journal-title":"Arzneimittelforschung"},{"key":"CIT0082","first-page":"330","volume":"57","author":"DuMez D","year":"2007","journal-title":"Arzneimittelforschung"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003174"},{"key":"CIT0084","author":"Johnson TJ","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05237-11"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/13543784.2012.655422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T15:44:15Z","timestamp":1593618255000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/13543784.2012.655422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":81,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,2,6]]},"published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1517\/13543784.2012.655422"],"URL":"https:\/\/doi.org\/10.1517\/13543784.2012.655422","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}