{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:39:35Z","timestamp":1790627975371,"version":"4.1.0"},"reference-count":127,"publisher":"Informa UK Limited","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1517\/13543784.2013.772979","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T13:57:55Z","timestamp":1361455075000},"page":"443-462","source":"Crossref","is-referenced-by-count":79,"title":["Optimizing biologically targeted clinical trials for neurofibromatosis"],"prefix":"10.1517","volume":"22","author":[{"given":"David H","family":"Gutmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaishri O","family":"Blakeley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R","family":"Korf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J","family":"Packer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550010065042"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33139"},{"key":"CIT0003","first-page":"26704","author":"Huson SM","year":"1989","journal-title":"J Med Genet"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.1.71"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.12.841"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20776"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990326)89:1<31::AID-AJMG7>3.0.CO;2-W"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.061051"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70092-1"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318165eb75"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34217-8"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21107"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.5.0747"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos076"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.6.1652"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000257095.33125.48"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.5.311"},{"key":"CIT0018","first-page":"36751","volume":"13","author":"Warbey V","year":"2009","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.5-6-477"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.049346"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33045"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.10.048"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2007.12.004"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.136457"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200205000-00002"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206002131"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162201001876"},{"key":"CIT0028","first-page":"91","volume":"70","author":"Evans GR","year":"2011","journal-title":"Adv Otorhinolaryngol"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nop010"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902579"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31825e73f5"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.3171\/2010.11.SPINE10350"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070010555030"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-002-0535-7"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1126\/science.2134734"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90252-A"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90017-9"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199911)46:5<777::AID-ANA15>3.0.CO;2-H"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.7.989"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002020309"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90151-4"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1038\/ng0296-144"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1038\/nn792"},{"key":"CIT0044","doi-asserted-by":"crossref","first-page":"8949","DOI":"10.1523\/JNEUROSCI.23-26-08949.2003","volume":"23","author":"Dasgupta B","year":"2003","journal-title":"J Neurosci"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3994-09.2010"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90406-G"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1038\/363515a0"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.2.267"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.10.004"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002314"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1964810"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0866"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01581-08"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01392-08"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200703010"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1038\/nature08279"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63193"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4058"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5916"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60578"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068452"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.14.5100-5113.2002"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02162"},{"key":"CIT0064","first-page":"8573","volume":"63","author":"Bajenaru ML","year":"2003","journal-title":"Cancer Res"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70414-X"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.041"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm059"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1038\/79075"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-011-9380-0"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401236101"},{"key":"CIT0071","author":"Blakeley JO","year":"2011","journal-title":"Am J Med Genet A"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-9867-7"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200601000-00020"},{"key":"CIT0074","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1200\/JCO.1991.9.12.2225","volume":"9","author":"O'Shaughnessy JA","year":"1991","journal-title":"J Clin Oncol"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000250332.89420.e6"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000333303.79931.83"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035711"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.21931"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.04.008"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.8638"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3107"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.3171\/2012.6.JNS112263"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2011.06.016"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0061"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1038\/nature10937"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4577"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.03.017"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.05.036"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.4161\/cc.11.2.19022"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3410"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.08.013"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1038\/ng0397-281"},{"key":"CIT0094","author":"Diggs-Andrews KA","journal-title":"Ann Neurol"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq382"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.060"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6867"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.07.004"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4558"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.12.027"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5447.2172"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5447.2176"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.07.011"},{"key":"CIT0105","author":"El-Hoss J","year":"2011","journal-title":"J Bone Miner Res"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr310"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.03.760"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2650"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1007\/BF02738732"},{"key":"CIT0110","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1101\/gad.14.13.1617","volume":"14","author":"Giovannini M","year":"2000","journal-title":"Genes Dev"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.8.978"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.609"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1101\/gad.226302"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.01.030"},{"key":"CIT0115","author":"Schulz A","journal-title":"Nat Med"},{"key":"CIT0116","first-page":"12","volume":"54","author":"Gupta A","year":"2000","journal-title":"Neurology"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.10.1461"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000243231.12248.67"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2007.01.009"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nor090"},{"key":"CIT0124","author":"Kim A","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"CIT0125","doi-asserted-by":"crossref","first-page":"524s","DOI":"10.1200\/jco.2006.24.18_suppl.9518","volume":"24","author":"Albritton KH","year":"2006","journal-title":"J Clin Oncol"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.4495"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.5054"},{"key":"CIT0128","first-page":"15s","volume":"28","author":"Schuetze S","year":"2009","journal-title":"J Clin Oncol"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680260047004"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.2165\/11634580-000000000-00000"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199905000-00007"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos146"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/13543784.2013.772979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T04:40:59Z","timestamp":1644381659000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/13543784.2013.772979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,21]]},"references-count":127,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,3,13]]},"published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1517\/13543784.2013.772979"],"URL":"https:\/\/doi.org\/10.1517\/13543784.2013.772979","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,21]]}}}