{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T15:13:33Z","timestamp":1778426013900,"version":"3.51.4"},"reference-count":166,"publisher":"Informa UK Limited","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1517\/13543784.2013.787408","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T08:13:53Z","timestamp":1366100033000},"page":"591-618","source":"Crossref","is-referenced-by-count":35,"title":["Potential clinical applications of chelating drugs in diseases targeting transferrin-bound iron and other metals"],"prefix":"10.1517","volume":"22","author":[{"given":"Christina N","family":"Kontoghiorghe","sequence":"first","affiliation":[{"name":"Postgraduate Research Institute of Science, Technology, Environment and Medicine, 3, Ammochostou Street, Limassol, CY 3021, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annita","family":"Kolnagou","sequence":"additional","affiliation":[{"name":"Postgraduate Research Institute of Science, Technology, Environment and Medicine, 3, Ammochostou Street, Limassol, CY 3021, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George J","family":"Kontoghiorghes","sequence":"additional","affiliation":[{"name":"Postgraduate Research Institute of Science, Technology, Environment and Medicine, 3, Ammochostou Street, Limassol, CY 3021, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2013,4,16]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1139\/o01-153"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.2174\/092986705774462969"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1080\/03630260600642450"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200326080-00003"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.2174\/092986705774463003"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(95)90038-1"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/S0021-9258(19)41699-2","volume":"250","author":"Schlabach MR","year":"1975","journal-title":"J Biol Chem"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.11.023"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/0162-0134(84)85049-7"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2742"},{"key":"CIT0011","first-page":"91","volume":"51","author":"Jacobs A","year":"1977","journal-title":"Ciba Found Symp"},{"key":"CIT0012","first-page":"1","volume":"51","author":"Aisen P","year":"1977","journal-title":"Ciba Found Symp"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"12034","DOI":"10.1016\/S0021-9258(18)43229-2","volume":"256","author":"Kojima N","year":"1981","journal-title":"J Biol Chem"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101825"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.2174\/092986705774463030"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb03662.x"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043364685"},{"key":"CIT0018","first-page":"277","volume-title":"Free radicals, oxidant stress and drug action","author":"Kontoghiorghes GJ","year":"1987"},{"key":"CIT0019","first-page":"150","volume":"35","author":"Djaldetti M","year":"1981","journal-title":"Biomedicine"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900040303"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2011.578950"},{"key":"CIT0022","first-page":"659","volume":"43","author":"Sheppard L","year":"1993","journal-title":"Arzheim Forsch Drug Res"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1986.tb02282.x"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.3.250"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.7.657"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.6.3.235"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2011.576906"},{"key":"CIT0029","first-page":"65","volume":"45","author":"Kontoghiorghes GJ","year":"1995","journal-title":"Arzn Forsch Drug Res"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2011.576153"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2010.03.021"},{"key":"CIT0032","first-page":"1099","volume":"37","author":"Kontoghiorghes GJ","year":"1987","journal-title":"Arz Forsch Drug Res"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(86)90288-8"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90164-9"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb00193.x"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1042\/bj2410087"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1693(00)81178-0"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007049701572"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1159\/000205877"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1042\/bj2540239"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)80201-7"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03570.x"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1965.tb54077.x"},{"key":"CIT0044","first-page":"640","volume":"21","author":"Lee P","year":"1993","journal-title":"Drug Metab Dispos"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.022962"},{"key":"CIT0046","first-page":"161","volume":"1","author":"Kontoghiorghes GJ","year":"2009","journal-title":"Front Biosci (Elite Ed)"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1517\/14740330903535845"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-3886(00)00087-4"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1977.tb01026.x"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.3109\/10715768709088079"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.295.6612.1509"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90545-9"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13309-0"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05396.x"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09740-4"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05195.x"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.4.1115"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-11-20"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(71)90300-0"},{"key":"CIT0060","first-page":"1332","volume":"40","author":"Kontoghiorghes GJ","year":"1990","journal-title":"Arzn Forsch Drug Res"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1007\/BF01140577"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1987.tb00776.x"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1693(00)91889-9"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb06441.x"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.10.3457"},{"key":"CIT0066","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1182\/blood.V71.4.1120.1120","volume":"71","author":"Pootrakul P","year":"1988","journal-title":"Blood"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1080\/01913120050118549"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1080\/03630260701726491"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90264-X"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.009118"},{"key":"CIT0071","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1365-2141.2010.08229.x","volume":"150","author":"Kolnagou A","year":"2010","journal-title":"Br J Haematol"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12225-8"},{"key":"CIT0073","unstructured":"Kontoghiorghes GJ. The design of orally active iron chelators for the treatment of thalassaemia. PhD thesis, University of Essex, Colchester UK; British Library Microfilm No D66194\/86 1982. p. 1-243"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.3109\/03630260903217182"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830420403"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(87)90065-1"},{"key":"CIT0077","first-page":"1099","volume":"37","author":"Kontoghiorghes GJ","year":"1987","journal-title":"Arz Forsch Drug Res"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1693(00)84951-8"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1358\/dof.1990.015.03.115233"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1007\/s007750000149"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(80)90329-3"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003253350"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1080\/03630260701727085"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01499.x"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07970.x"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2010.485890"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(85)80859-0"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1990.147"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.2.110"},{"key":"CIT0090","first-page":"3","volume":"28","author":"Sheppard L","year":"1992","journal-title":"Drugs Today"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb07887.x"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1159\/000089475"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-250308"},{"key":"CIT0094","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/clinchem\/36.1.5","volume":"36","author":"Goddard JG","year":"1990","journal-title":"Clin Chem"},{"key":"CIT0095","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1128\/MMBR.42.1.45-66.1978","volume":"42","author":"Weinberg ED","year":"1978","journal-title":"Microbiol Rev"},{"key":"CIT0096","first-page":"9","volume":"28","author":"Evans RW","year":"1992","journal-title":"Drugs Today"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1080\/03630260701727119"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.2174\/092986705774462996"},{"key":"CIT0099","first-page":"2925","volume":"49","author":"Blatt J","year":"1989","journal-title":"Cancer Res"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(01)00225-6"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.07.002"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2010.483662"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.45.26723"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01411.x"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91136-4"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80606-8"},{"key":"CIT0107","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1182\/blood.V79.2.308.308","volume":"79","author":"Gordeuk VR","year":"1992","journal-title":"Blood"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.4.350"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1988.tb02490.x"},{"key":"CIT0110","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1182\/blood.V72.1.358.358","volume":"72","author":"Heppner DG","year":"1988","journal-title":"Blood"},{"key":"CIT0111","first-page":"17","volume":"115","author":"Mohanty D","year":"2002","journal-title":"Indian J Med Res"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03159.x"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl350"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32338"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(03)00055-X"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04976.x"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(95)03301-U"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.07.020"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-009-0565-x"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1201\/9781420030853"},{"key":"CIT0121","first-page":"598","volume":"119","author":"Halliwell B","year":"1992","journal-title":"J Lab Clin Med"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.3109\/03630260903217141"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21563"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.586"},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830340106"},{"key":"CIT0126","first-page":"35","volume":"9","author":"Vreugdenhil G","year":"1991","journal-title":"Clin Exp Rheumatol"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92011-4"},{"key":"CIT0128","unstructured":"Baldamus CA, Scigalla P, Wieczorek L, Koch KM. editors. Erythropoietin: from molecular structure to clinical application. Karger, Pub, Germany; 1989. p. 1-350"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6450.961"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-065433"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-010-0212-7"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22002"},{"key":"CIT0134","first-page":"57","volume":"18","author":"Rajapurkar MM","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"CIT0135","first-page":"329A","volume":"18","author":"Rajapurkar MM","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.2174\/092986705774462987"},{"key":"CIT0137","first-page":"522","volume":"44","author":"Kontoghiorghes GJ","year":"1994","journal-title":"Arzn Forsch Drug Res"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90544-X"},{"key":"CIT0139","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1693(00)84710-6"},{"key":"CIT0140","first-page":"169","volume":"28","author":"Volf V","year":"1992","journal-title":"Drugs Today"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1007\/BF02345915"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1021\/bi00403a033"},{"key":"CIT0143","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2008.08.002"},{"key":"CIT0144","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-6-199403150-00008"},{"key":"CIT0145","first-page":"1103","volume":"11","author":"Sava G","year":"1991","journal-title":"Anticancer Res"},{"key":"CIT0146","doi-asserted-by":"crossref","first-page":"14717","DOI":"10.1016\/S0021-9258(17)38631-3","volume":"260","author":"Ponka P","year":"1985","journal-title":"J Biol Chem"},{"key":"CIT0147","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2012.730558"},{"key":"CIT0148","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14085-8"},{"key":"CIT0149","unstructured":"Exjade (deferasirox) tablets for oral suspension. Highlights of prescribing information. Novartis Pharmaceutical Corp, USA; T2011-106 2011. p. 1-16"},{"issue":"12","key":"CIT0150","first-page":"1","volume":"15","author":"Anonymous","year":"2010","journal-title":"ISMP Medication Safety Alert"},{"key":"CIT0154","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199005020-00005"},{"key":"CIT0155","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-065805"},{"issue":"88","key":"CIT0156","first-page":"72","volume":"16","year":"2007","journal-title":"Prescrire Int"},{"key":"CIT0157","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.03.013"},{"key":"CIT0158","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M440"},{"key":"CIT0159","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181ec0c38"},{"key":"CIT0160","doi-asserted-by":"publisher","DOI":"10.1177\/0003319710394160"},{"key":"CIT0161","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11782"},{"key":"CIT0162","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.70.5.373"},{"key":"CIT0163","first-page":"176","volume":"29","author":"Cases A","year":"1988","journal-title":"Clin Nephrol"},{"key":"CIT0164","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90641-7"},{"key":"CIT0165","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02357-6"},{"key":"CIT0166","doi-asserted-by":"publisher","DOI":"10.3109\/03630260903212043"},{"key":"CIT0167","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12413"},{"key":"CIT0168","first-page":"CD007476","volume":"2","author":"Meerpohl JJ","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"91","key":"CIT0169","first-page":"196","volume":"16","author":"Anonymous","year":"2007","journal-title":"Prescrire Int"},{"key":"CIT0170","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2011.03.007"},{"key":"CIT0171","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.070607"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/13543784.2013.787408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T23:45:22Z","timestamp":1715211922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1517\/13543784.2013.787408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,16]]},"references-count":166,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,3,22]]},"published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1517\/13543784.2013.787408"],"URL":"https:\/\/doi.org\/10.1517\/13543784.2013.787408","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,16]]}}}