{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:24:22Z","timestamp":1788449062918,"version":"build-2803163510"},"reference-count":87,"publisher":"Informa Healthcare","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Pharmacotherapy"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1517\/14656566.2010.514903","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T13:28:32Z","timestamp":1290518912000},"page":"1-12","source":"Crossref","is-referenced-by-count":33,"title":["Rapidly progressive dementias and the treatment of human prion diseases"],"prefix":"10.1517","volume":"12","author":[{"given":"Brian S","family":"Appleby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine G","family":"Lyketsos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3197","published-online":{"date-parts":[[2010,11,23]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ncl.2007.04.001","volume":"25","author":"Geschwind MD","year":"2007","journal-title":"Neurol Clin"},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ana.21430","volume":"64","author":"Geschwind MD","year":"2008","journal-title":"Ann Neurol"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1055\/s-2007-985337","volume":"27","author":"Woodruff BK","year":"2007","journal-title":"Semin Neurol"},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/archneurol.2008.534","volume":"66","author":"Josephs KA","year":"2009","journal-title":"Arch Neurol"},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/WNN.0b013e318192cc8d","volume":"22","author":"Kelley BJ","year":"2009","journal-title":"Cogn Behav Neurol"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/WAD.0b013e31819e099b","volume":"23","author":"Papageorgiou SG","year":"2009","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/2151043a0","volume":"215","author":"Griffith JS","year":"1967","journal-title":"Nature"},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.6801762","volume":"216","author":"Prusiner SB","year":"1982","journal-title":"Science"},{"key":"CIT0009","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.tibs.2006.01.002","volume":"31","author":"Soto C","year":"2006","journal-title":"Trends in Biochem Sci"},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"14083","DOI":"10.1074\/jbc.C110.113464","volume":"285","author":"Kim J","year":"2010","journal-title":"J Biol Chem"},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.1183748","volume":"327","author":"Wang F","year":"2010","journal-title":"Science"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/0092-8674(93)90360-3","volume":"73","author":"Bueler H","year":"1993","journal-title":"Cell"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/214764a0","volume":"214","author":"Alper T","year":"1967","journal-title":"Nature"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0092-8674(83)90207-6","volume":"35","author":"McKinley MP","year":"1983","journal-title":"Cell"},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1056\/NEJM199812313392707","volume":"339","author":"Johnson RT","year":"1998","journal-title":"N Engl J Med"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1146\/annurev.pathmechdis.3.121806.154326","volume":"3","author":"Aguzzi A","year":"2008","journal-title":"Annu Rev Pathol"},{"key":"CIT0018","first-page":"208","volume":"66","author":"Appleby BS","year":"2009","journal-title":"Arch Neurol"},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1176\/jnp.2007.19.4.428","volume":"19","author":"Appleby B","year":"2007","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.clinph.2005.12.007","volume":"117","author":"Wieser HG","year":"2006","journal-title":"Clin Neurophysiol"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/archneur.60.6.813","volume":"60","author":"Geschwind MD","year":"2003","journal-title":"Arch Neurol"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1093\/brain\/awp191","volume":"132","author":"Zerr I","year":"2009","journal-title":"Brain"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0140-6736(84)92880-0","volume":"323","author":"David A","year":"1984","journal-title":"Lancet"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0140-6736(84)91302-3","volume":"323","author":"Newman PK","year":"1984","journal-title":"Lancet"},{"key":"CIT0025","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1136\/bmj.280.6218.902-a","volume":"280","author":"Kovanen J","year":"1980","journal-title":"Br Med J"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0140-6736(82)90652-3","volume":"320","author":"Furlow T","year":"1982","journal-title":"Lancet"},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1001\/archneur.1983.04050080055010","volume":"40","author":"Terzano MG","year":"1983","journal-title":"Arch Neurol"},{"key":"CIT0028","first-page":"47","volume":"30","author":"Neri G","year":"1984","journal-title":"Riv Neurobiol"},{"key":"CIT0029","first-page":"18","volume":"40","author":"Ratcliffe J","year":"1975","journal-title":"Bull Los Angeles Neurol Soc"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/bmj.4.5781.212","volume":"4","author":"Braham J","year":"1971","journal-title":"Br Med J"},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/jnnp.36.4.581","volume":"36","author":"Sanders WL","year":"1973","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/jnnp.42.10.960","volume":"42","author":"Sanders WL","year":"1979","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF02043951","volume":"3","author":"Villa G","year":"1982","journal-title":"Ital J Neurol Sci"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1099\/0022-1317-68-1-219","volume":"68","author":"Pocchiari M","year":"1987","journal-title":"J Gen Virol"},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/infdis\/165.4.784","volume":"165","author":"Masullo C","year":"1992","journal-title":"J Infect Dis"},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0140-6736(03)12273-8","volume":"361","author":"Floel A","year":"2003","journal-title":"Lancet"},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1590\/S0004-282X2004000200029","volume":"62","author":"Arruda WO","year":"2004","journal-title":"Arq Neuropsiquiatr"},{"key":"CIT0038","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000069083","volume":"49","author":"Imperiale D","year":"2003","journal-title":"Eur Neurol"},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yebeh.2009.10.016","volume":"17","author":"Belcastro V","year":"2010","journal-title":"Epilepsy Behav"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2002.10719189"},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1006\/exnr.1997.6559","volume":"147","author":"Perovic S","year":"1997","journal-title":"Exp Neurol"},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1212\/01.WNL.0000113764.35026.EF","volume":"62","author":"Otto M","year":"2004","journal-title":"Neurology"},{"key":"CIT0043","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1093\/brain\/awh249","volume":"127","author":"Pocchiari M","year":"2004","journal-title":"Brain"},{"key":"CIT0044","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2174\/187152709789542014","volume":"8","author":"Riemer C","year":"2009","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"CIT0045","doi-asserted-by":"crossref","first-page":"9836","DOI":"10.1073\/pnas.161274798","volume":"98","author":"Korth C","year":"2001","journal-title":"Proc Natl Acad Sci"},{"key":"CIT0046","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/ana.10530","volume":"53","author":"Scoazec J","year":"2003","journal-title":"Ann Neurol"},{"key":"CIT0047","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000076350","volume":"17","author":"Nakajima M","year":"2004","journal-title":"Dement Geriatr Cogn Disord"},{"key":"CIT0048","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s10571-004-6926-7","volume":"24","author":"Satoh K","year":"2004","journal-title":"Cell Mol Neurobiol"},{"key":"CIT0049","first-page":"403","volume":"43","author":"Kobayashi Y","year":"2003","journal-title":"Rinsho Shinkeigaku"},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.surneu.2005.03.035","volume":"64","author":"Martinez-Lage JF","year":"2005","journal-title":"Surg Neurol"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/01.wnf.0000134853.36429.0e","volume":"27","author":"Benito-Leon J","year":"2004","journal-title":"Clin Neuropharmacol"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0035-3787(05)85062-3","volume":"161","author":"Bertrand A","year":"2005","journal-title":"Rev Neurol"},{"key":"CIT0053","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S1474-4422(09)70049-3","volume":"8","author":"Collinge J","year":"2009","journal-title":"Lancet Neurol"},{"key":"CIT0054","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1212\/01.WNL.0000148596.15681.4D","volume":"63","author":"Haik S","year":"2004","journal-title":"Neurology"},{"key":"CIT0055","unstructured":"Geschwind M, Kuo A, Raudabaugh B, A randomized, double-blind, controlled study of the efficacy of quinacrine in the treatment of sporadic CJD. Poster presentation at Thessaloniki-Chalkidiki: Prion 2009"},{"key":"CIT0057","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2174\/187152709789541961","volume":"8","author":"Appleby BS","year":"2009","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"CIT0058","first-page":"194","volume":"27","author":"Dervaux A","year":"2001","journal-title":"Encephale"},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/mds.870070118","volume":"7","author":"Clarke CE","year":"1992","journal-title":"Mov Disord"},{"key":"CIT0060","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1099\/0022-1317-65-8-1325","volume":"65","author":"Ehlers B","year":"1984","journal-title":"J Gen Virol"},{"key":"CIT0061","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1128\/JVI.78.10.4999-5006.2004","volume":"78","author":"Doh-ura K","year":"2004","journal-title":"J Virol"},{"key":"CIT0062","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/bmj.326.7379.8\/a","volume":"326","author":"Dyer O","year":"2003","journal-title":"BMJ"},{"key":"CIT0063","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/bmj.327.7418.770-b","volume":"327","author":"Gould M","year":"2003","journal-title":"BMJ"},{"key":"CIT0064","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/bmj.327.7418.765","volume":"327","author":"Mayor S","year":"2003","journal-title":"BMJ"},{"key":"CIT0065","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jinf.2004.07.015","volume":"50","author":"Todd N","year":"2005","journal-title":"J Infect"},{"key":"CIT0066","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00701-006-0772-y","volume":"148","author":"Whittle IR","year":"2006","journal-title":"Acta Neurochir"},{"key":"CIT0067","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1136\/jnnp.2006.104505","volume":"78","author":"Parry A","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"CIT0068","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1600-0404.2009.01272.x","volume":"121","author":"Terada T","year":"2010","journal-title":"Acta Neurol Scand"},{"key":"CIT0069","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1517\/14712598.7.5.713","volume":"7","author":"Rainov NG","year":"2007","journal-title":"Expert Opin Biol Ther"},{"key":"CIT0070","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1468-1331.2008.02108.x","volume":"15","author":"Bone I","year":"2008","journal-title":"Eur J Neurol"},{"key":"CIT0071","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1440-1789.2009.01058.x","volume":"29","author":"Tsuboi Y","year":"2009","journal-title":"Neuropathology"},{"key":"CIT0072","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2174\/1871526510909010023","volume":"9","author":"Forloni G","year":"2009","journal-title":"Infect Disord Drug Targets"},{"key":"CIT0073","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2174\/1871526510909010092","volume":"9","author":"Zerr I","year":"2009","journal-title":"Infect Disord Drug Targets"},{"key":"CIT0074","doi-asserted-by":"crossref","first-page":"e1888","DOI":"10.1371\/journal.pone.0001888","volume":"3","author":"De Luigi A","year":"2008","journal-title":"PLoS ONE"},{"key":"CIT0075","unstructured":"Zerr I. Clinical diagnosis of CJD: are there predictors of treatment response? Oral presentation at Thessaloniki-Chalkidiki: Prion 2009"},{"key":"CIT0076","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.neurol.2009.10.013","volume":"166","author":"Brandel J","year":"2010","journal-title":"Rev Neurol"},{"key":"CIT0077","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2174\/092986609787601804","volume":"16","author":"Sakaguchi S","year":"2009","journal-title":"Protein Pept Lett"},{"key":"CIT0078","doi-asserted-by":"crossref","first-page":"342","DOI":"10.2174\/187152709789541934","volume":"8","author":"White MD","year":"2009","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"CIT0079","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1126\/science.1090187","volume":"302","author":"Mallucci G","year":"2003","journal-title":"Science"},{"key":"CIT0080","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neuron.2007.01.005","volume":"53","author":"Mallucci GR","year":"2007","journal-title":"Neuron"},{"key":"CIT0081","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1152\/physrev.00007.2007","volume":"88","author":"Linden R","year":"2008","journal-title":"Physiol Rev"},{"key":"CIT0082","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/370295a0","volume":"370","author":"Collinge J","year":"1994","journal-title":"Nature"},{"key":"CIT0083","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/brain\/awl003","volume":"129","author":"Cortelli P","year":"2006","journal-title":"Brain"},{"key":"CIT0084","unstructured":"Appleby BS, Appleby KK, Onyike CU, Wallin MT. Initial diagnosis predicts survival time in human prion disease. Poster presentation at Madrid: Prion 2008"},{"key":"CIT0085","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1093\/brain\/awl150","volume":"129","author":"Trevitt CR","year":"2006","journal-title":"Brain"},{"key":"CIT0086","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1212\/01.wnl.0000308955.25760.c2","volume":"70","author":"Stewart L","year":"2008","journal-title":"Neurology"},{"key":"CIT0087","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2174\/187152709789541989","volume":"8","author":"Brown P","year":"2009","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"CIT0088","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1468-1331.2008.02109.x","volume":"15","author":"Pocchiari M","year":"2008","journal-title":"Eur J Neurol"},{"key":"CIT0089","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W","volume":"46","author":"Parchi P","year":"1999","journal-title":"Ann Neurol"}],"container-title":["Expert Opinion on Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14656566.2010.514903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T16:27:46Z","timestamp":1497889666000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/14656566.2010.514903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,23]]},"references-count":87,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,11,23]]},"published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1517\/14656566.2010.514903"],"URL":"https:\/\/doi.org\/10.1517\/14656566.2010.514903","relation":{},"ISSN":["1465-6566","1744-7666"],"issn-type":[{"value":"1465-6566","type":"print"},{"value":"1744-7666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,23]]}}}