{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:01:37Z","timestamp":1770508897790,"version":"3.49.0"},"reference-count":66,"publisher":"Informa UK Limited","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Pharmacotherapy"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1517\/14656566.2013.765859","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T07:31:16Z","timestamp":1359444676000},"page":"489-504","source":"Crossref","is-referenced-by-count":11,"title":["Asenapine for the treatment of manic and mixed episodes associated with bipolar I disorder: from clinical research to clinical practice"],"prefix":"10.1517","volume":"14","author":[{"given":"Andrea","family":"Fagiolini","sequence":"first","affiliation":[{"name":"University of Siena, Departments of Mental Health and Molecular Medicine","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco N","family":"Forgione","sequence":"additional","affiliation":[{"name":"University of Siena, Departments of Mental Health and Molecular Medicine","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetto","family":"Morana","sequence":"additional","affiliation":[{"name":"Morana Hospital and Clinic","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Maccari","sequence":"additional","affiliation":[{"name":"University of Siena, Departments of Mental Health and Molecular Medicine","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Goracci","sequence":"additional","affiliation":[{"name":"University of Siena, Departments of Mental Health and Molecular Medicine","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Bossini","sequence":"additional","affiliation":[{"name":"University of Siena, Departments of Mental Health and Molecular Medicine","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"University of Siena, Departments of Mental Health and Molecular Medicine","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Cuomo","sequence":"additional","affiliation":[{"name":"University of Siena, Departments of Mental Health and Molecular Medicine","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Casamassima","sequence":"additional","affiliation":[{"name":"University of Siena, Departments of Mental Health and Molecular Medicine","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2013,1,29]]},"reference":[{"key":"e_1_3_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.6.530"},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-440X(96)90018-8"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.15"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.06.003"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200321090-00001"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200822080-00004"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181bef8a6"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0320"},{"issue":"2","key":"e_1_3_1_10_1","first-page":"20","article-title":"Managing anticholinergic side effects","volume":"6","author":"Lieberman JA","year":"2004","unstructured":"Lieberman JA III. Managing anticholinergic side effects. Prim Care Companion J Clin Psychiatry 2004;6(Suppl 2):20-3","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806994"},{"key":"e_1_3_1_12_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/104012371102300107","article-title":"Cardiovascular morbidity and mortality in bipolar disorder","volume":"23","author":"Weiner M","year":"2011","unstructured":"Weiner M, Warren L, Fiedorowicz JG. Cardiovascular morbidity and mortality in bipolar disorder. Ann Clin Psychiatry 2011;23:40-7","journal-title":"Ann Clin Psychiatry"},{"key":"e_1_3_1_13_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10m05997"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02228.x"},{"key":"e_1_3_1_15_1","unstructured":"FDA Psychopharmacologic Drugs Advisory Committee Meeting SAPHRIS\u00ae (asenapine) Sublingual Tablets (NDA 22-117). 2009;Available from: http:\/\/www.fda.gov\/downloads\/AdvisoryCommittees\/CommitteesMeetingMaterials\/Drugs\/PsychopharmacologicDrugsAdvisoryCommittee\/UCM173876.pdf [[Accessed 13 October 2012]; Saphris package insert. Available from: http:\/\/www.spfiles.com\/pisaphrisv1.pdf [[Accessed October 2012]"},{"key":"e_1_3_1_16_1","unstructured":"Hulskotte E Spaans E Timmer C Effects of water intake and smoking on absorption of sublingually administered asenapine. Poster presented at the 110th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT); 18 \u2013 21 March 2009; Washington USA"},{"key":"e_1_3_1_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881107082944"},{"key":"e_1_3_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2008.11.001"},{"key":"e_1_3_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1098-7"},{"key":"e_1_3_1_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900025086"},{"key":"e_1_3_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300027"},{"key":"e_1_3_1_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125311430112"},{"key":"e_1_3_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20618"},{"key":"e_1_3_1_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108095704"},{"key":"e_1_3_1_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709990824"},{"key":"e_1_3_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00748.x"},{"key":"e_1_3_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.12.028"},{"key":"e_1_3_1_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31823f872f"},{"key":"e_1_3_1_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-11-101"},{"key":"e_1_3_1_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00749.x"},{"key":"e_1_3_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.04.005"},{"key":"e_1_3_1_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009344855"},{"key":"e_1_3_1_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S29891"},{"key":"e_1_3_1_34_1","article-title":"Asenapine for elderly bipolar manic patients","author":"Baruch Y","year":"2012","unstructured":"Baruch Y, Tadger S, Plopski I, Barak Y. Asenapine for elderly bipolar manic patients. J Affect Disord 2012; Epub ahead of print","journal-title":"J Affect Disord"},{"key":"e_1_3_1_35_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.9.1651"},{"key":"e_1_3_1_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000169068.34322.70"},{"key":"e_1_3_1_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881106059693"},{"key":"e_1_3_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2005.02.006"},{"key":"e_1_3_1_39_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0116"},{"key":"e_1_3_1_40_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.6.1057"},{"key":"e_1_3_1_41_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.187.3.235"},{"key":"e_1_3_1_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.12.1218"},{"key":"e_1_3_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2004.06.003"},{"key":"e_1_3_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60873-8"},{"key":"e_1_3_1_45_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0611"},{"key":"e_1_3_1_46_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.1.112"},{"key":"e_1_3_1_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00234.x"},{"key":"e_1_3_1_48_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0423c"},{"key":"e_1_3_1_49_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.7075su1c.04"},{"key":"e_1_3_1_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622970902823202"},{"key":"e_1_3_1_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051688"},{"key":"e_1_3_1_52_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0704"},{"key":"e_1_3_1_53_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0401"},{"key":"e_1_3_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.01.036"},{"issue":"8","key":"e_1_3_1_55_1","first-page":"30","article-title":"Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxiety","volume":"66","author":"Blier P","year":"2005","unstructured":"Blier P, Szabo ST. Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxiety. J Clin Psychiatry 2005;66(Suppl 8):30-40; Review","journal-title":"J Clin Psychiatry"},{"key":"e_1_3_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.11.015"},{"key":"e_1_3_1_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1456-5"},{"key":"e_1_3_1_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1570-z"},{"key":"e_1_3_1_59_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1019628"},{"key":"e_1_3_1_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.11.1079"},{"key":"e_1_3_1_61_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.7.1263"},{"key":"e_1_3_1_62_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1281"},{"key":"e_1_3_1_63_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.247"},{"key":"e_1_3_1_64_1","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1097\/01.yic.0000405712.98984.94","article-title":"Early improvement predicts later outcome in manic or mixed episodes associated with bipolar I disorder: post hoc analyses of asenapine studies","volume":"26","author":"Prowse A","year":"2011","unstructured":"Prowse A, Zhao J, Ha X, Early improvement predicts later outcome in manic or mixed episodes associated with bipolar I disorder: post hoc analyses of asenapine studies. Int Clin Psychophar 2011;26:e47","journal-title":"Int Clin Psychophar"},{"key":"e_1_3_1_65_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0217"},{"key":"e_1_3_1_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2009.07.004"},{"key":"e_1_3_1_67_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.4.442"}],"container-title":["Expert Opinion on Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14656566.2013.765859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T18:25:50Z","timestamp":1770402350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1517\/14656566.2013.765859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,29]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1517\/14656566.2013.765859"],"URL":"https:\/\/doi.org\/10.1517\/14656566.2013.765859","relation":{},"ISSN":["1465-6566","1744-7666"],"issn-type":[{"value":"1465-6566","type":"print"},{"value":"1744-7666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,29]]}}}