{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:13:34Z","timestamp":1793924014768,"version":"4.8.0"},"reference-count":91,"publisher":"Informa Healthcare","issue":"5","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Pharmacotherapy"],"published-print":{"date-parts":[[2015,3,24]]},"DOI":"10.1517\/14656566.2015.1013937","type":"journal-article","created":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T07:37:59Z","timestamp":1423553879000},"page":"711-726","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":18,"title":["Treating pulmonary hypertension in pediatrics"],"prefix":"10.1517","volume":"16","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Lador","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Sekarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Beghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3197","published-online":{"date-parts":[[2015,2,9]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.032"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.029"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"D34","DOI":"10.1016\/j.jacc.2013.10.025","volume":"62","author":"Tuder RM","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMra040291","author":"Humbert M","year":"2004","journal-title":"N Engl J Med"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306173282402"},{"issue":"1","key":"CIT0006","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.jacc.2009.04.006","volume":"54","author":"Hassoun PM","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nrcardio.2011.104","volume":"8","author":"O\u2019Callaghan DS","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092306"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1668OC"},{"issue":"2","key":"CIT0010","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/CIRCULATIONAHA.109.911818","volume":"122","author":"Humbert M","year":"2010","journal-title":"Circulation"},{"issue":"1","key":"CIT0011","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/CIRCULATIONAHA.111.026591","volume":"125","author":"Barst RJ","year":"2012","journal-title":"Circulation"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61621-8"},{"issue":"2","key":"CIT0013","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jpeds.2009.02.036","volume":"155","author":"van Loon RL","year":"2009","journal-title":"J Pediatr"},{"issue":"1","key":"CIT0014","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.amjcard.2010.02.023","volume":"106","author":"van Loon RL","year":"2010","journal-title":"Am J Cardiol"},{"issue":"4","key":"CIT0015","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1136\/hrt.2008.150086","volume":"95","author":"Haworth SG","year":"2009","journal-title":"Heart"},{"issue":"2","key":"CIT0016","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4103\/2045-8932.83456","volume":"1","author":"Cerro MJ","year":"2011","journal-title":"Pulm Circ"},{"issue":"1","key":"CIT0017","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/j.semperi.2005.02.003","volume":"29","author":"Farrow KN","year":"2005","journal-title":"Semin Perinatol"},{"issue":"16","key":"CIT0018","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1161\/CIRCULATIONAHA.110.969584","volume":"124","author":"van Loon RL","year":"2011","journal-title":"Circulation"},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1183\/09031936.00056110","volume":"37","author":"Barst RJ","year":"2011","journal-title":"Eur Respir J"},{"issue":"3","key":"CIT0020","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1183\/09031936.00140112","volume":"42","author":"Beghetti M","year":"2013","journal-title":"Eur Respir J"},{"issue":"24","key":"CIT0021","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1093\/eurheartj\/ehr282","volume":"32","author":"Douwes JM","year":"2011","journal-title":"Eur Heart J"},{"issue":"5","key":"CIT0022","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7326\/0003-4819-115-5-343","volume":"115","author":"D\u2019Alonzo GE","year":"1991","journal-title":"Ann Intern Med"},{"issue":"2","key":"CIT0023","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/0735-1097(94)00391-3","volume":"25","author":"Sandoval J","year":"1995","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"CIT0024","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/eurheartj\/eht072","volume":"35","author":"Manes A","year":"2014","journal-title":"Eur Heart J"},{"key":"CIT0025","doi-asserted-by":"crossref","first-page":"D117","DOI":"10.1016\/j.jacc.2013.10.028","volume":"62","author":"Ivy DD","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1093\/eurheartj\/ehp297","volume":"30","author":"Gali\u00e8 N","year":"2009","journal-title":"Eur Heart J"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.182378"},{"issue":"3","key":"CIT0028","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1378\/chest.114.3.787","volume":"114","author":"Rich S","year":"1998","journal-title":"Chest"},{"issue":"3","key":"CIT0029","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1747-0803.2012.00633.x","volume":"7","author":"Sandoval J","year":"2012","journal-title":"Congenit Heart Dis"},{"issue":"6","key":"CIT0030","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1183\/09031936.00030414","volume":"44","author":"Ploegstra MJ","year":"2014","journal-title":"Eur Respir J"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.031"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138104.83366.E9"},{"issue":"24","key":"CIT0033","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1093\/eurheartj\/ehr282","volume":"32","author":"Douwes JM","year":"2011","journal-title":"Eur Heart J"},{"issue":"9","key":"CIT0034","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1161\/01.CIR.99.9.1197","volume":"99","author":"Barst RJ","year":"1999","journal-title":"Circulation"},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ppedcard.2009.09.005","volume":"27","author":"Kulik T","year":"2009","journal-title":"Prog Pediatr Cardiol"},{"issue":"4","key":"CIT0036","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1378\/chest.89.4.497","volume":"89","author":"Barst RJ","year":"1986","journal-title":"Chest"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207093270203"},{"issue":"23","key":"CIT0038","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1161\/CIRCULATIONAHA.104.488486","volume":"111","author":"Sitbon O","year":"2005","journal-title":"Circulation"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06250-X"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012212"},{"issue":"4","key":"CIT0041","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0009-9236(03)00005-5","volume":"73","author":"Barst RJ","year":"2003","journal-title":"Clin Pharmacol Ther"},{"key":"CIT0042","volume-title":"Full Prescribing Information","author":"Tracleer (Bosentan)","year":"2011"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0688-2"},{"issue":"2","key":"CIT0044","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1183\/09031936.00194810","volume":"37","author":"Gali\u00e8 N","year":"2011","journal-title":"Eur Respir J"},{"issue":"2","key":"CIT0045","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2174\/157016109787455653","volume":"7","author":"Beghetti M","year":"2009","journal-title":"Curr Vasc Pharmacol"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318179954c"},{"issue":"1","key":"CIT0047","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.106.630715","volume":"114","author":"Galie N","year":"2006","journal-title":"Circulation"},{"issue":"1","key":"CIT0048","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1183\/09031936.00053510","volume":"38","author":"Hislop AA","year":"2011","journal-title":"Eur Respir J"},{"issue":"4","key":"CIT0049","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.jacc.2005.01.066","volume":"46","author":"Rosenzweig EB","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"CIT0050","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.amjcard.2010.06.064","volume":"106","author":"Ivy DD","year":"2010","journal-title":"Am J Cardiol"},{"issue":"4","key":"CIT0051","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.ahj.2007.06.003","volume":"154","author":"van Loon RL","year":"2007","journal-title":"Am Heart J"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.742510"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.033"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22555"},{"issue":"9","key":"CIT0055","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.amjcard.2010.12.051","volume":"107","author":"Zuckerman WA","year":"2011","journal-title":"Am J Cardiol"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213917"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.655266"},{"issue":"20","key":"CIT0058","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1056\/NEJMoa050010","volume":"353","author":"Galie N","year":"2005","journal-title":"N Engl J Med"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.09.002"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.09.021"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.016667"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005698"},{"issue":"4","key":"CIT0064","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0022-5223(98)70369-1","volume":"115","author":"Ivy DD","year":"1998","journal-title":"J Thorac Cardiovasc Surg"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.06.012"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.839274"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0180-4"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209655"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209657"},{"issue":"6","key":"CIT0070","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1164\/ajrccm.159.6.9804054","volume":"159","author":"Tuder RM","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"CIT0071","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.amjcard.2009.12.075","volume":"105","author":"Melnick L","year":"2010","journal-title":"Am J Cardiol"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.6.2106079"},{"issue":"5","key":"CIT0073","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.amjcard.2006.09.119","volume":"99","author":"Ivy DD","year":"2007","journal-title":"Am J Cardiol"},{"issue":"2","key":"CIT0074","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jacc.2007.09.031","volume":"51","author":"Ivy DD","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"CIT0075","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/01.CIR.103.4.544","volume":"103","author":"Rimensberger PC","year":"2001","journal-title":"Circulation"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01786-2"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00463-7"},{"issue":"4","key":"CIT0078","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1183\/09031936.00137511","volume":"40","author":"Simonneau G","year":"2012","journal-title":"Eur Respir J"},{"issue":"20","key":"CIT0079","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.jacc.2014.02.575","volume":"63","author":"Zijlstra WM","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"CIT0080","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1007\/s00246-012-0597-9","volume":"34","author":"Takatsuki S","year":"2013","journal-title":"Pediatr Cardiol"},{"issue":"3","key":"CIT0081","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1136\/heartjnl-2013-304895","volume":"100","author":"Douwes JM","year":"2014","journal-title":"Heart"},{"issue":"2","key":"CIT0082","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jacc.2007.09.031","volume":"51","author":"Ivy DD","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"CIT0083","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.healun.2013.01.1055","volume":"32","author":"Siehr SL","year":"2013","journal-title":"J Heart Lung Transplant"},{"issue":"5","key":"CIT0084","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1183\/09031936.05.00075305","volume":"26","author":"Hoeper MM","year":"2005","journal-title":"Eur Respir J"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00028404"},{"issue":"11","key":"CIT0086","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1164\/rccm.200603-358OC","volume":"174","author":"McLaughlin VV","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-8-200810210-00004"},{"issue":"6","key":"CIT0088","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1183\/09031936.00116313","volume":"43","author":"Sitbon O","year":"2014","journal-title":"Eur Respir J"},{"issue":"25","key":"CIT0089","doi-asserted-by":"crossref","first-page":"D73","DOI":"10.1016\/j.jacc.2013.10.034","volume":"62","author":"McLaughlin VV","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"CIT0090","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0735-1097(98)00238-1","volume":"32","author":"Sandoval J","year":"1998","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"CIT0091","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.athoracsur.2012.10.069","volume":"96","author":"Latus H","year":"2013","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"CIT0092","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1183\/09031936.00030414","volume":"44","author":"Ploegstra MJ","journal-title":"Eur Respir J"}],"container-title":["Expert Opinion on Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14656566.2015.1013937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T20:15:04Z","timestamp":1566332104000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/14656566.2015.1013937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,9]]},"references-count":91,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,2,3]]},"published-print":{"date-parts":[[2015,3,24]]}},"alternative-id":["10.1517\/14656566.2015.1013937"],"URL":"https:\/\/doi.org\/10.1517\/14656566.2015.1013937","relation":{},"ISSN":["1465-6566","1744-7666"],"issn-type":[{"value":"1465-6566","type":"print"},{"value":"1744-7666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,9]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieop20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieop20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}