{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:56:46Z","timestamp":1790423806069,"version":"4.1.0"},"reference-count":55,"publisher":"Informa Healthcare","issue":"8","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Pharmacotherapy"],"published-print":{"date-parts":[[2015,5,24]]},"DOI":"10.1517\/14656566.2015.1041504","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T05:41:52Z","timestamp":1430286112000},"page":"1255-1262","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":20,"title":["Ezetimibe plus simvastatin for the treatment of hypercholesterolemia"],"prefix":"10.1517","volume":"16","author":[{"given":"Steven E","family":"Gryn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Hegele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3197","published-online":{"date-parts":[[2015,4,28]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2012.06495.x","volume":"1254","author":"Kovacic JC","year":"2012","journal-title":"Ann N Y Acad Sci"},{"issue":"9841","key":"CIT0002","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(12)60367-5","volume":"380","author":"Cholesterol Treatment Trialists CTT","year":"2012","journal-title":"Lancet"},{"issue":"1","key":"CIT0003","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/CRD.0b013e3181fc212a","volume":"19","author":"Silverman MG","year":"2011","journal-title":"Cardiol Rev"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437738.63853.7a"},{"issue":"4","key":"CIT0005","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cjca.2014.01.009","volume":"30","author":"Anderson TJ","year":"2014","journal-title":"Can J Cardiol"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.09.023"},{"issue":"1","key":"CIT0007","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s11883-012-0296-2","volume":"15","author":"Steinberg D","year":"2013","journal-title":"Curr Atheroscler Rep"},{"key":"CIT0008","first-page":"1","volume":"177","author":"Gu Q","year":"2014","journal-title":"NCHS Data Brief"},{"issue":"5","key":"CIT0009","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/jama.2013.284657","volume":"311","author":"Ioannidis JP","year":"2014","journal-title":"JAMA"},{"issue":"17","key":"CIT0010","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1056\/NEJMsa0801461","volume":"358","author":"Jackevicius CA","year":"2008","journal-title":"N Engl J Med"},{"issue":"9","key":"CIT0011","first-page":"1486","volume":"174","author":"Ross JS","year":"2014","journal-title":"JAMA"},{"issue":"5","key":"CIT0012","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ahj.2014.01.014","volume":"167","author":"Lu L","year":"2014","journal-title":"Am Heart J"},{"issue":"6","key":"CIT0013","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2165\/00129784-200404060-00009","volume":"4","author":"Murdoch D","year":"2004","journal-title":"Am J Cardiovasc Drugs"},{"issue":"1370","key":"CIT0014","first-page":"61","volume":"53","year":"2011","journal-title":"Med Letter Drugs Ther"},{"issue":"1","key":"CIT0016","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1567-5688(03)00003-5","volume":"4","author":"Istvan E","year":"2003","journal-title":"Atherosclerosis Supplements"},{"issue":"9808","key":"CIT0017","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/S0140-6736(11)61125-2","volume":"378","author":"Heart Protection Study Collaborative Group","year":"2011","journal-title":"Lancet"},{"issue":"1","key":"CIT0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/jm030283g","volume":"47","author":"Clader JW","year":"2004","journal-title":"J Med Chem"},{"issue":"3","key":"CIT0019","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5551\/jat.14.99","volume":"14","author":"Davis HR","year":"2007","journal-title":"J Atheroscler Thromb"},{"issue":"3","key":"CIT0020","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/MOL.0b013e3283613a55","volume":"24","author":"Couture P","year":"2013","journal-title":"Curr Opin Lipidol"},{"issue":"7","key":"CIT0021","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1194\/jlr.P800061-JLR200","volume":"50","author":"Tremblay AJ","year":"2009","journal-title":"J Lipid Res"},{"issue":"3","key":"CIT0022","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1194\/jlr.M600439-JLR200","volume":"48","author":"Telford DE","year":"2007","journal-title":"J Lipid Res"},{"issue":"11","key":"CIT0023","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.cjca.2013.08.003","volume":"29","author":"Ziada A","year":"2013","journal-title":"Can J Cardiol"},{"issue":"4","key":"CIT0024","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1586\/14779072.4.4.461","volume":"4","author":"Robinson JG","year":"2006","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"2","key":"CIT0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5414\/CPP44083","volume":"44","author":"Migoya EM","year":"2006","journal-title":"Int J Clin Pharmacol Ther"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2003.25.6.769652"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200847070-00003"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199324030-00002"},{"issue":"8","key":"CIT0029","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1124\/dmd.108.026146","volume":"37","author":"de Waart DR","year":"2009","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"CIT0030","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2165\/00003088-200544050-00002","volume":"44","author":"Kosoglou T","year":"2005","journal-title":"Clin Pharmacokinet"},{"issue":"1","key":"CIT0031","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/clpt.2014.82","volume":"96","author":"Gryn SE","year":"2014","journal-title":"Clin Pharmacol Ther"},{"issue":"4","key":"CIT0032","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/clpt.2014.125","volume":"96","author":"Ramsey LB","year":"2014","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"CIT0033","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/clpt.2012.57","volume":"92","author":"Wilke RA","year":"2012","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"CIT0034","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1399-0004.2004.00388.x","volume":"67","author":"Wang J","year":"2005","journal-title":"Clin Genet"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-4-16"},{"issue":"6","key":"CIT0036","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.ygeno.2005.08.007","volume":"86","author":"Simon JS","year":"2005","journal-title":"Genomics"},{"issue":"6","key":"CIT0037","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1073\/pnas.0508483103","volume":"103","author":"Cohen JC","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"CIT0038","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1210\/jc.2009-1952","volume":"95","author":"Lakoski SG","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"CIT0039","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1194\/jlr.P001172","volume":"51","author":"Polisecki E","year":"2010","journal-title":"J Lipid Res"},{"issue":"22","key":"CIT0040","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1056\/NEJMoa1405386","volume":"371","author":"Myocardial Infarction Genetics Consortium I","year":"2014","journal-title":"N Engl J Med"},{"key":"CIT0041","volume-title":"IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT Trial): A Comparison of Ezetimibe\/Simvastatin versus Simvastatin Monotherapy on Cardiovascular Outcomes After Acute Coronary Syndromes","author":"Cannon CP","year":"2014"},{"issue":"6","key":"CIT0042","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1161\/CIRCGENETICS.114.000606","volume":"7","author":"Snowden SG","year":"2014","journal-title":"Circ Cardiovasc Gen"},{"issue":"14","key":"CIT0043","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1056\/NEJMoa0800742","volume":"358","author":"Kastelein JJ","year":"2008","journal-title":"N Engl J Med"},{"issue":"3","key":"CIT0044","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1161\/ATVBAHA.114.305012","volume":"35","author":"McPherson R","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"25","key":"CIT0045","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/j.jacc.2008.10.031","volume":"52","author":"Fleg JL","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"22","key":"CIT0046","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1056\/NEJMoa0907569","volume":"361","author":"Taylor AJ","year":"2009","journal-title":"N Engl J Med"},{"issue":"1","key":"CIT0047","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.atherosclerosis.2011.05.028","volume":"218","author":"Taylor AJ","year":"2011","journal-title":"Atherosclerosis"},{"issue":"9784","key":"CIT0048","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/S0140-6736(11)60739-3","volume":"377","author":"Baigent C","year":"2011","journal-title":"Lancet"},{"issue":"4","key":"CIT0049","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/1074248412449384","volume":"17","author":"Ye Y","year":"2012","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"1","key":"CIT0050","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.atherosclerosis.2012.11.028","volume":"227","author":"Westerink J","year":"2013","journal-title":"Atherosclerosis"},{"issue":"12","key":"CIT0051","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.cjca.2014.08.020","volume":"30","author":"Wise SJ","year":"2014","journal-title":"Can J Cardiol"},{"key":"CIT0052","author":"Luo L","year":"2015","journal-title":"Int Med J"},{"issue":"2","key":"CIT0053","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.clinthera.2005.02.011","volume":"27","author":"Masana L","year":"2005","journal-title":"Clin Ther"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.4030"},{"issue":"1","key":"CIT0055","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijcard.2014.06.049","volume":"176","author":"Roth EM","year":"2014","journal-title":"Int J Cardiol"},{"issue":"11","key":"CIT0056","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1517\/13543784.2013.822485","volume":"22","author":"Lee P","year":"2013","journal-title":"Expert Opin Investig Drugs"}],"container-title":["Expert Opinion on Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14656566.2015.1041504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T10:30:23Z","timestamp":1498213823000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/14656566.2015.1041504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,28]]},"references-count":55,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,4,26]]},"published-print":{"date-parts":[[2015,5,24]]}},"alternative-id":["10.1517\/14656566.2015.1041504"],"URL":"https:\/\/doi.org\/10.1517\/14656566.2015.1041504","relation":{},"ISSN":["1465-6566","1744-7666"],"issn-type":[{"value":"1465-6566","type":"print"},{"value":"1744-7666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,28]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieop20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieop20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}