{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:49:31Z","timestamp":1792183771905,"version":"4.4.0"},"reference-count":87,"publisher":"Informa UK Limited","issue":"7","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Biological Therapy"],"published-print":{"date-parts":[[2013,8,1]]},"DOI":"10.1517\/14712598.2013.779251","type":"journal-article","created":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T09:02:36Z","timestamp":1363078956000},"page":"1029-1038","source":"Crossref","is-referenced-by-count":7,"title":["Using TRIM5\u03b1 as an HIV therapeutic: the alpha gene?"],"prefix":"10.1517","volume":"13","author":[{"given":"Joseph S","family":"Anderson","sequence":"first","affiliation":[{"name":"University of California Davis, Internal Medicine","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.334.6061.1338"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e328340ffa6"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1385\/IR:25:1:53"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-1-200107030-00005"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-009-0037-5"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000233310.90484.16"},{"key":"e_1_3_1_9_1","first-page":"156","article-title":"Update of the drug resistance mutations in HIV-1: december 2010","volume":"18","author":"Johnson VA","year":"2010","unstructured":"Johnson VA, Brun-Vezinet F, Clotet B, et al. Update of the drug resistance mutations in HIV-1: december 2010. Top HIV Med 2010;18:156-63","journal-title":"Top HIV Med"},{"key":"e_1_3_1_10_1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.coviro.2011.10.020","article-title":"Drug resistance in HIV-1","volume":"1","author":"Kuritzkes DR","year":"2011","unstructured":"Kuritzkes DR. Drug resistance in HIV-1. Curr Opin Virol 2011;1:582-9","journal-title":"Curr Opin Virol"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.20.10948"},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/135965350000500101"},{"key":"e_1_3_1_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.9.2475-2484.2000"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1293.2001.00078.x"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181f25574"},{"key":"e_1_3_1_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01109-10"},{"key":"e_1_3_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21651"},{"key":"e_1_3_1_18_1","first-page":"88","article-title":"Failure to reconstitute CD4+ T-cells despite suppression of HIV replication under HAART","volume":"8","author":"Aiuti F and Mezzaroma I","year":"2006","unstructured":"Aiuti F and Mezzaroma I. Failure to reconstitute CD4+ T-cells despite suppression of HIV replication under HAART. AIDS Rev 2006;8:88-97","journal-title":"AIDS Rev"},{"key":"e_1_3_1_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318134257a"},{"key":"e_1_3_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283324283"},{"key":"e_1_3_1_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/595851"},{"key":"e_1_3_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200209270-00002"},{"key":"e_1_3_1_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/597093"},{"key":"e_1_3_1_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/595888"},{"key":"e_1_3_1_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f47082"},{"key":"e_1_3_1_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir626"},{"key":"e_1_3_1_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016210790442713"},{"key":"e_1_3_1_28_1","first-page":"112","article-title":"Fat redistribution syndromes associated with HIV-1 infection and combination antiretroviral therapy","volume":"14","author":"Domingo P","year":"2012","unstructured":"Domingo P, Estrada V, Lopez-Aldeguer J, et al. Fat redistribution syndromes associated with HIV-1 infection and combination antiretroviral therapy. AIDS Rev 2012;14:112-23","journal-title":"AIDS Rev"},{"key":"e_1_3_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.01.020"},{"key":"e_1_3_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2004.03.005"},{"key":"e_1_3_1_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1932"},{"key":"e_1_3_1_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000931"},{"key":"e_1_3_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.12.015"},{"key":"e_1_3_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.02.024"},{"key":"e_1_3_1_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06300-11"},{"key":"e_1_3_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(92)90002-V"},{"key":"e_1_3_1_37_1","first-page":"313","article-title":"Umbilical cord blood hematopoietic stem and repopulating cells in human clinical transplantation","volume":"17","author":"Broxmeyer HE","year":"1991","unstructured":"Broxmeyer HE, Kurtzberg J, Gluckman E, et al. Umbilical cord blood hematopoietic stem and repopulating cells in human clinical transplantation. Blood Cells 1991;17:313-29","journal-title":"Blood Cells"},{"key":"e_1_3_1_38_1","first-page":"437","article-title":"Gene therapy using hematopoietic stem cells","volume":"1","author":"Kohn DB","year":"1999","unstructured":"Kohn DB. Gene therapy using hematopoietic stem cells. Curr Opin Mol Ther 1999;1:437-42","journal-title":"Curr Opin Mol Ther"},{"key":"e_1_3_1_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802905"},{"key":"e_1_3_1_40_1","first-page":"267","article-title":"Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply exposed individuals to HIV-1 infection","volume":"86","author":"Liu R","year":"1996","unstructured":"Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply exposed individuals to HIV-1 infection. Cell 1996;86:267-77","journal-title":"Cell"},{"key":"e_1_3_1_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1196-1240"},{"key":"e_1_3_1_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.7.3114-3124.2002"},{"key":"e_1_3_1_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328340fe28"},{"key":"e_1_3_1_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.1.368.413a47_368_371"},{"key":"e_1_3_1_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2008.124"},{"key":"e_1_3_1_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302801"},{"key":"e_1_3_1_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2842"},{"key":"e_1_3_1_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.187"},{"key":"e_1_3_1_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302958"},{"key":"e_1_3_1_50_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2007.108"},{"key":"e_1_3_1_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.21.11531-11535.2003"},{"key":"e_1_3_1_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02343"},{"key":"e_1_3_1_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.7.3930-3937.2005"},{"key":"e_1_3_1_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403364101"},{"key":"e_1_3_1_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402876101"},{"key":"e_1_3_1_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402474101"},{"key":"e_1_3_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.09.048"},{"key":"e_1_3_1_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402361101"},{"key":"e_1_3_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.07.291"},{"key":"e_1_3_1_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1248"},{"key":"e_1_3_1_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7883-7888.2005"},{"key":"e_1_3_1_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505659102"},{"key":"e_1_3_1_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02777"},{"key":"e_1_3_1_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09976"},{"key":"e_1_3_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.10.035"},{"key":"e_1_3_1_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.5.3139-3145.2005"},{"key":"e_1_3_1_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1203536109"},{"key":"e_1_3_1_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1210903109"},{"key":"e_1_3_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.05.017"},{"key":"e_1_3_1_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02318-06"},{"key":"e_1_3_1_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1562"},{"key":"e_1_3_1_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.01.003"},{"key":"e_1_3_1_73_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00270-06"},{"key":"e_1_3_1_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409853102"},{"key":"e_1_3_1_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.12.042"},{"key":"e_1_3_1_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2010.40"},{"key":"e_1_3_1_77_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39354"},{"key":"e_1_3_1_78_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2012.083"},{"key":"e_1_3_1_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.03.023"},{"key":"e_1_3_1_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-4-40"},{"key":"e_1_3_1_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.08.032"},{"key":"e_1_3_1_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/372359a0"},{"key":"e_1_3_1_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709511105"},{"key":"e_1_3_1_84_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000003"},{"key":"e_1_3_1_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709258105"},{"key":"e_1_3_1_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709003105"},{"key":"e_1_3_1_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.09.019"},{"key":"e_1_3_1_88_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/sj.gt.3302852","article-title":"Inhibition of HIV-1 replication by simian restriction factors","volume":"14","author":"Sakuma JA","year":"2007","unstructured":"Sakuma JA, Noser JA, Ohmine S, et al. Inhibition of HIV-1 replication by simian restriction factors. Gene Ther 2007;14:185-9","journal-title":"Gene Ther"},{"key":"e_1_3_1_89_1","article-title":"Generation of an HIV resistant T-cell line by targeted \u201cStacking\u201d of restriction factors","author":"Voit RA","year":"2013","unstructured":"Voit RA, McMahon MA, Sawyer SL, et al. Generation of an HIV resistant T-cell line by targeted \u201cStacking\u201d of restriction factors. Mol Ther 2013; [Epub ahead of print]","journal-title":"Mol Ther"}],"container-title":["Expert Opinion on Biological Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14712598.2013.779251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1517\/14712598.2013.779251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14712598.2013.779251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:37:59Z","timestamp":1785159479000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1517\/14712598.2013.779251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,12]]},"references-count":87,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,8,1]]}},"alternative-id":["10.1517\/14712598.2013.779251"],"URL":"https:\/\/doi.org\/10.1517\/14712598.2013.779251","relation":{},"ISSN":["1471-2598","1744-7682"],"issn-type":[{"value":"1471-2598","type":"print"},{"value":"1744-7682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,12]]}}}