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Discovers ICOS as a CD28 homologue on activated human T cells, and shows that ICOS crosslinking in conjunction with a T cell receptor signal upregulates cytokine production, particularly of IL-10 but not of IL\u20132.","DOI":"10.1038\/16717"},{"key":"CIT0017","first-page":"3887","volume":"11","author":"ISHIDA Y","year":"1992","journal-title":"A novel member of the immunoglobulin gene superfamily, upon programmed cell death. 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