{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:43:44Z","timestamp":1785782624923,"version":"3.56.0"},"reference-count":134,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Emerging Drugs"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1517\/14728214.9.2.223","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T15:28:56Z","timestamp":1103729336000},"page":"223-236","source":"Crossref","is-referenced-by-count":11,"title":["Use of cytokines in infection"],"prefix":"10.1517","volume":"9","author":[{"given":"Naoko","family":"Aoki","sequence":"first","affiliation":[{"name":"McMaster University, Department of Pathology and Molecular Medicine, Infectious Diseases Division, Centre for Gene Therapeutics, Rm. 4012 - MDCL, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Xing","sequence":"additional","affiliation":[{"name":"McMaster University, Department of Pathology and Molecular Medicine, Infectious Diseases Division, Centre for Gene Therapeutics, Rm. 4012 - MDCL, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5. xingz@mcmaster.ca"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2005,2,24]]},"reference":[{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612003400623"},{"key":"e_1_2_1_4_1","unstructured":"\u2022A well-organised review about the use of cytokines as therapeutics."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.12.8.1297"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2002.tb02691.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319523"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2003.12.002"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.296.5567.490"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","unstructured":"NGUYEN KB WATFORD WT SALOMON R et al.: Critical role for STAT4 activation by Type 1 interferons in the interferon-gamma response to viral infection. Science (2002) 297 (5589):2063\u20132066.","DOI":"10.1126\/science.1074900"},{"issue":"10","key":"e_1_2_1_11_1","first-page":"5794","volume":"77","author":"BOT A","year":"2003","unstructured":"BOT A, RODRIGO E, WOLFE T, BOT S, VON HERRATH MG: Infection-triggered regulatory mechanisms over-ride the role of STAT 4 in control of the immune response to influenza virus antigens. Vim\/. (2003) 77(10):5794\u20135800.","journal-title":"Vim\/"},{"issue":"4","key":"e_1_2_1_12_1","first-page":"689","volume":"47","author":"XING Z","year":"2001","unstructured":"XING Z: Breach of IL-12 monopoly in the initiation of Type 1 immunity to intracellular infections: IL-12 is not required for host defense against viral infection. Cell. Ma Biol. (2001) 47(4):689\u2013694.","journal-title":"Cell. Ma Biol"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(02)00210-9"},{"issue":"3","key":"e_1_2_1_14_1","first-page":"223","volume":"8","author":"KIDD P","year":"2003","unstructured":"KIDD P: Thl\/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Ahern. Med.. Rev (2003) 8(3):223\u2013246.","journal-title":"Ahern. Med.. Rev"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80702-3"},{"key":"e_1_2_1_16_1","unstructured":"\u2022\u2022The new finding of the transcription factorT-bet which controls Thl immunity."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215093"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","unstructured":"ZHENG W FLAVELL RA: The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 89(4):587\u2013596.","DOI":"10.1016\/S0092-8674(00)80240-8"},{"issue":"2","key":"e_1_2_1_19_1","first-page":"129","volume":"9","author":"SHIRAFUJI Y","year":"1999","unstructured":"SHIRAFUJI Y, MATSUURA H, SATO A, KANZAKI H, KATAYAMA H, ARATA J: Hyperimmunoglobin E syndrome: a sign of TH1\/TH2 imbalance? Eur: Dermatol (1999) 9(2):129\u2013131.","journal-title":"Eur: Dermatol"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2001.tb01308.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.4.993"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(98)00097-7"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","unstructured":"HUBEL K DALE DC LILES WC: Therapeutic use of cytokines to modulate phagocyte function for the treatment of infectious diseases: current status of granulocyte colony-stimulating factor granulocyte-macrophage colony-stimulating factor macrophage colony-stimulating factor and interferon-gamma. Infect. Dis. (2002) 185(10):1490\u20131501. Epub 2002 Apr 19.","DOI":"10.1086\/340221"},{"issue":"6","key":"e_1_2_1_24_1","first-page":"665","volume":"6","author":"RODRIGUEZ FH","year":"2000","unstructured":"RODRIGUEZ FH, NELSON S, KOLLS JK: Cytokine therapeutics for infectious diseases. Can: Pharm. Des. (2000) 6(6):665\u2013680.","journal-title":"Can: Pharm. Des"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.6.1737.1737"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119758"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90046-2"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.1.109"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00241-4"},{"key":"e_1_2_1_30_1","unstructured":"CAIRO MS PLUNKETT JM MAUSS D VAN DE VEN C: Seven-day administration of recombinant human granulocyte colony-stimulating factor to"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.9.1788.1788"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200003100-00012"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(02)90116-8"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-3-199508010-00009"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(98)00007-0"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6224"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199612263352602"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199612263352604"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2901"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324038"},{"key":"e_1_2_1_41_1","unstructured":"\u2022\u2022Consideration of redundant role of IL-12in defence against infection other than mycobacteria and salmonella."},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8456301"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.4.1435"},{"issue":"6","key":"e_1_2_1_44_1","first-page":"827","volume":"75","author":"DECKERT-SCHLUTER M","year":"1996","unstructured":"DECKERT-SCHLUTER M, RANG A, WEINER D et al.: Interferon-gamma receptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation. Lab. Invest. (1996) 75(6):827\u2013841.","journal-title":"Lab. Invest"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8456300"},{"key":"e_1_2_1_46_1","unstructured":"GALLIN JI: Delineation of the phagocyte NADPH wddase through studies of chronic granulomatous diseases of childhood. bit. .1 Tissue React. (1993) 15(3):99\u2013103."},{"key":"e_1_2_1_47_1","doi-asserted-by":"crossref","unstructured":"VERCELLI D JABARA HH CUNNINGHAM-RUNDLES C: Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome. .1. Clin. Invest. (1990) 85(5):1666\u20131671.","DOI":"10.1172\/JCI114618"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82151-1"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15109-4"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00118-9"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2002.01101.x"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.9.1403"},{"key":"e_1_2_1_53_1","doi-asserted-by":"crossref","unstructured":"COOPER AM KIPNIS A TURNER J MAGRAM J FERRANTE J ORME IM: Mice lacking bioactive IL-12 can generate protective antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. .1. Immunol (2002) 168(3):1322\u20131327.","DOI":"10.4049\/jimmunol.168.3.1322"},{"key":"e_1_2_1_54_1","doi-asserted-by":"crossref","unstructured":"OPPMANN B LESLEY R BLOM B et al.: Novel p19 protein engages IL-12p40 to form a cytokine IL-23 with biological activities similar as well as distinct from IL-12. Immunity (2000) 13(5):715\u2013725.","DOI":"10.1016\/S1074-7613(00)00070-4"},{"key":"e_1_2_1_55_1","unstructured":"\u2022\u2022It reports the finding of a new Type 1cytokine IL-23 composed of IL-12p40 and novel p19."},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0602326"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00324-2"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612003400533"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401189"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612033392567"},{"key":"e_1_2_1_61_1","unstructured":"\u2022History and prospects of cytokine therapy against bacterial sepsis."},{"issue":"2","key":"e_1_2_1_62_1","first-page":"524","volume":"21","author":"DINARELLO CA","year":"2003","unstructured":"DINARELLO CA: Anticytoldne therapeutics and infections. Vaccine (2003) 21 (Suppl. 2):524\u201334.","journal-title":"Vaccine"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011110"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18991"},{"key":"e_1_2_1_65_1","unstructured":"\u2022This paper reveals a new role by TNF in host defence and cautions the clinical use of the TNF inhibitors."},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1388"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5270.1955"},{"key":"e_1_2_1_68_1","unstructured":"\u2022\u2022This article illustrates that CCR5 is aprimary co-receptor for macrophage-tropic HIV."},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/40894"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5243.1811"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/382829a0"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/382833a0"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200402000-00003"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570162033485357"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440521"},{"key":"e_1_2_1_76_1","doi-asserted-by":"crossref","unstructured":"GONZALEZ E ROVIN BH SEN L et al.: HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels. Proc. Nati Acad. Sci. USA (2002) 99(21):13795\u201313800. Epub 2002 Oct 08.","DOI":"10.1073\/pnas.202357499"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199811000-00014"},{"key":"e_1_2_1_78_1","doi-asserted-by":"crossref","unstructured":"XING Z: The hunt for new tuberculosis vaccines: antiTB immunity and rational design of vaccines. Carr: Pharm. Des.(2001) 7(11):1015\u20131037.","DOI":"10.2174\/1381612013397636"},{"key":"e_1_2_1_79_1","unstructured":"\u2022An in-depth review of antituberculosis immunity and vaccine development."},{"key":"e_1_2_1_80_1","doi-asserted-by":"crossref","unstructured":"MANTOVANI A LOCATI M VECCHI A SOZZANI S ALLAVENA P: Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines. Trends Immunol (2001) 22(6):328\u2013336.","DOI":"10.1016\/S1471-4906(01)01941-X"},{"key":"e_1_2_1_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.1.1"},{"key":"e_1_2_1_82_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.12.6448"},{"key":"e_1_2_1_83_1","doi-asserted-by":"crossref","unstructured":"CRIBBS DH GHOCHIKYAN A VASILEVKO V et al.: Adjuvant-dependent modulation of Thl and Th2 responses to immunization with beta-amyloid.Int. Immunol (2003) 15(4):505\u2013514.","DOI":"10.1093\/intimm\/dxg049"},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.238-246.2004"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2002.01078.x"},{"issue":"3","key":"e_1_2_1_86_1","first-page":"341","volume":"1","author":"WANG J","year":"2002","unstructured":"WANG J, XING Z: Tuberculosis vaccines: the past, present and future. Expert Rev. Vaccines (2002) 1(3):341\u2013354.","journal-title":"Vaccines"},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1396"},{"key":"e_1_2_1_88_1","doi-asserted-by":"crossref","unstructured":"MARTIN GS MANNINO DM EATON S MOSS M: Epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med. (2003) 348 (16): 1546\u20131554.","DOI":"10.1056\/NEJMoa022139"},{"key":"e_1_2_1_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91728-4"},{"key":"e_1_2_1_90_1","doi-asserted-by":"crossref","unstructured":"TRACEY KJ BEUTLER B LOWRY SF et al.: Shock and tissue injury induced by recombinant human cachectin. Science (1986) 234 (4775):470\u2013474.","DOI":"10.1126\/science.3764421"},{"key":"e_1_2_1_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/330662a0"},{"key":"e_1_2_1_92_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3895437"},{"key":"e_1_2_1_93_1","unstructured":"\u2022\u2022The first report on anti-TNF therapyagainst lethal effect of endotoxin."},{"issue":"3","key":"e_1_2_1_94_1","first-page":"1548","volume":"151","author":"MOHLER KM","year":"1993","unstructured":"MOHLER KM, TORRANCE DS, SMITH CA et al.: Soluble tumour necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. Immunol (1993) 151(3):1548\u20131561.","journal-title":"Immunol"},{"key":"e_1_2_1_95_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520360048038"},{"key":"e_1_2_1_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199609000-00002"},{"key":"e_1_2_1_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60602-2"},{"key":"e_1_2_1_98_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200103000-00001"},{"key":"e_1_2_1_99_1","author":"SANTOSUOSSO M","year":"2004","unstructured":"SANTOSUOSSO M, WANG J, XING Z In: Progress M Tuberculosis Research, Frank Columbus (Ed.), Nova Science Publishers, Inc., Hauppauge, NY. (2004) (In press).","journal-title":"Progress M Tuberculosis Research"},{"key":"e_1_2_1_100_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.68.6.897"},{"key":"e_1_2_1_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.5.2948-2953.2000"},{"issue":"4","key":"e_1_2_1_102_1","first-page":"1541","volume":"158","author":"KOHNO K","year":"1997","unstructured":"KOHNO K, KATAOKA J, OHTSUKI T et al.: IFN-gamma-inducing factor (TGIF) is a costimulatory factor on the activation of Thl but not Th2 cells and exerts its effect independently of IL-12. .1 Immunol (1997) 158(4):1541\u20131550.","journal-title":"Immunol"},{"key":"e_1_2_1_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.63.6.658"},{"key":"e_1_2_1_104_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7014"},{"key":"e_1_2_1_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00074-4"},{"key":"e_1_2_1_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(01)00092-0"},{"key":"e_1_2_1_107_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.7.3698"},{"key":"e_1_2_1_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00346-6"},{"key":"e_1_2_1_109_1","doi-asserted-by":"publisher","DOI":"10.1086\/313663"},{"key":"e_1_2_1_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00251-2"},{"key":"e_1_2_1_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10345"},{"key":"e_1_2_1_112_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1293.2001.00077.x"},{"key":"e_1_2_1_113_1","doi-asserted-by":"publisher","DOI":"10.1086\/315764"},{"key":"e_1_2_1_114_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.1.63"},{"key":"e_1_2_1_115_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251539598"},{"key":"e_1_2_1_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5342.1447"},{"key":"e_1_2_1_117_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.9.5838-5842.1995"},{"key":"e_1_2_1_118_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503023320904"},{"key":"e_1_2_1_119_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610313351803"},{"key":"e_1_2_1_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00079-8"},{"key":"e_1_2_1_121_1","unstructured":"\u2022This review describes a new approach of therapeutic use of chemokines against HIV infection."},{"key":"e_1_2_1_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80110-5"},{"key":"e_1_2_1_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200011)30:11<3190::AID-IMMU3190>3.0.CO;2-E"},{"key":"e_1_2_1_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/89653"},{"key":"e_1_2_1_125_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.21.11567"},{"key":"e_1_2_1_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(96)92700-0"},{"issue":"3","key":"e_1_2_1_127_1","first-page":"S157\u2013S187","volume":"37","author":"STEINBACH WJ","year":"2003","unstructured":"STEINBACH WJ, STEVENS DA: Review of newer antifungal and immunomodulatory strategies for invasive aspergillosis. Clin. Infect. Dis. (2003) 37 (Suppl. 3):S157\u2013S187.","journal-title":"Clin. Infect. Dis"},{"key":"e_1_2_1_128_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110489"},{"key":"e_1_2_1_129_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.4.1185-1193.1993"},{"key":"e_1_2_1_130_1","doi-asserted-by":"crossref","unstructured":"ROMANI L MENCACCI A GROHMANN U et al.: Neutralizing antibody to IL-4 induces systemic protection and T helper Type 1-associated immunity in murine candidiasis. .1. Exp. Med. (1992) 176(1):19\u201325.","DOI":"10.1084\/jem.176.1.19"},{"key":"e_1_2_1_131_1","doi-asserted-by":"crossref","unstructured":"MAYER P SCHUTZE E LAM C KRICEK F LIEHL E: Recombinant murine granulocyte-macrophage colony-stimulating factor augments neutrophil recovery and enhances resistance to infections in myelosuppressed mice. .1. Infect. Dis. (1991) 163(3):584\u2013590.","DOI":"10.1093\/infdis\/163.3.584"},{"key":"e_1_2_1_132_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.70.6.868"},{"key":"e_1_2_1_133_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.4.705"},{"key":"e_1_2_1_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.2.192"},{"key":"e_1_2_1_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01691218"},{"key":"e_1_2_2_2_1","unstructured":"http:\/\/www.iddb.com\/ The Investigational Drugs database 01997\u20132004 Derwent Information Ltd."}],"container-title":["Expert Opinion on Emerging Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14728214.9.2.223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T09:24:10Z","timestamp":1770369850000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1517\/14728214.9.2.223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":134,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1517\/14728214.9.2.223"],"URL":"https:\/\/doi.org\/10.1517\/14728214.9.2.223","relation":{},"ISSN":["1472-8214","1744-7623"],"issn-type":[{"value":"1472-8214","type":"print"},{"value":"1744-7623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}