{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:09:15Z","timestamp":1777961355466,"version":"3.51.4"},"reference-count":108,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Therapeutic Targets"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1517\/14728222.2011.546351","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T10:15:43Z","timestamp":1294222543000},"page":"169-181","source":"Crossref","is-referenced-by-count":42,"title":["Therapeutic targeting of osteoclast function and pathways"],"prefix":"10.1517","volume":"15","author":[{"given":"Matthew L","family":"Broadhead","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan CM","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crispin R","family":"Dass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter FM","family":"Choong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian E","family":"Myers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2011,1,5]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500703"},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","volume":"423","author":"Boyle WJ","year":"2003","journal-title":"Nature"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2302\/kjm.52.1","volume":"52","author":"Miyamoto T","year":"2003","journal-title":"Keio J Med"},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/283669a0","volume":"283","author":"Ash P","year":"1980","journal-title":"Nature"},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"Pittenger MF","year":"1999","journal-title":"Science"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1210\/endo-122-4-1373","volume":"122","author":"Takahashi N","year":"1988","journal-title":"Endocrinology"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"Lacey DL","year":"1998","journal-title":"Cell"},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","volume":"95","author":"Yasuda H","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"CIT0009","first-page":"204","volume":"8","author":"Yavropoulou MP","year":"2008","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0945-053X(00)00052-4","volume":"19","author":"Lerner UH","year":"2000","journal-title":"Matrix Biol"},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/bbrc.1998.9788","volume":"253","author":"Nakagawa N","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1073\/pnas.96.7.3540","volume":"96","author":"Hsu H","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","volume":"89","author":"Simonet WS","year":"1997","journal-title":"Cell"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/bbrc.1997.6603","volume":"234","author":"Tsuda E","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1056\/NEJMoa013096","volume":"347","author":"Whyte MP","year":"2002","journal-title":"N Engl J Med"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/71667","volume":"24","author":"Hughes AE","year":"2000","journal-title":"Nat Genet"},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1359\/jbmr.2003.18.8.1381","volume":"18","author":"Nakatsuka K","year":"2003","journal-title":"J Bone Miner Res"},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1210\/endo.139.3.5837","volume":"139","author":"Yasuda H","year":"1998","journal-title":"Endocrinology"},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/36593","volume":"390","author":"Anderson DM","year":"1997","journal-title":"Nature"},{"key":"CIT0020","first-page":"363","volume":"122","author":"Baron R","year":"1986","journal-title":"Am J Pathol"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.20050645","volume":"202","author":"Yagi M","year":"2005","journal-title":"J Exp Med"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/nm1514","volume":"12","author":"Lee SH","year":"2006","journal-title":"Nat Med"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"11846","DOI":"10.1074\/jbc.M512624200","volume":"281","author":"Yao Z","year":"2006","journal-title":"J Biol Chem"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/jbmr.5650111014","volume":"11","author":"Weir EC","year":"1996","journal-title":"J Bone Miner Res"},{"key":"CIT0025","doi-asserted-by":"crossref","unstructured":"Alberts B, Johnson A, Lewis J, Molecular biology of the cell. 5th edition: Garland Science, New York; 2008","DOI":"10.1201\/9780203833445"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1196\/annals.1346.014","volume":"1068","author":"Ross FP","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1046\/j.1365-2443.1999.00265.x","volume":"4","author":"Naito A","year":"1999","journal-title":"Genes Cells"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/excr.1999.4733","volume":"254","author":"Inoue J","year":"2000","journal-title":"Exp Cell Res"},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/emboj\/20.6.1271","volume":"20","author":"Kobayashi N","year":"2001","journal-title":"EMBO J"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-08-0530"},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nm1203","volume":"11","author":"Wada T","year":"2005","journal-title":"Nat Med"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-065X.2009.00821.x","volume":"231","author":"Negishi-Koga T","year":"2009","journal-title":"Immunol Rev"},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"8286","DOI":"10.1074\/jbc.M206421200","volume":"278","author":"Komarova SV","year":"2003","journal-title":"J Biol Chem"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2008.10.146","volume":"378","author":"Soysa NS","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.bcp.2006.08.007","volume":"72","author":"Dejardin E","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1038\/nm1197-1285"},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.20042081","volume":"201","author":"Ruocco MG","year":"2005","journal-title":"J Exp Med"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80232-4"},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nm752","volume":"8","author":"Takeshita S","year":"2002","journal-title":"Nat Med"},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"41147","DOI":"10.1074\/jbc.M205063200","volume":"277","author":"Ishida N","year":"2002","journal-title":"J Biol Chem"},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","volume":"3","author":"Takayanagi H","year":"2002","journal-title":"Dev Cell"},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.20051150","volume":"202","author":"Asagiri M","year":"2005","journal-title":"J Exp Med"},{"key":"CIT0043","doi-asserted-by":"crossref","first-page":"26475","DOI":"10.1074\/jbc.M313973200","volume":"279","author":"Matsuo K","year":"2004","journal-title":"J Biol Chem"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1038\/nm1270"},{"key":"CIT0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0945-053X(00)00051-2","volume":"19","author":"Duong LT","year":"2000","journal-title":"Matrix Biol"},{"key":"CIT0046","doi-asserted-by":"crossref","first-page":"20369","DOI":"10.1016\/S0021-9258(18)54932-2","volume":"266","author":"Miyauchi A","year":"1991","journal-title":"J Biol Chem"},{"key":"CIT0047","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00784-009-0268-2","volume":"13","author":"Proff P","year":"2009","journal-title":"Clin Oral Investig"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.037"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1007\/0-306-46826-3_32"},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/70563","volume":"23","author":"Li YP","year":"1999","journal-title":"Nat Genet"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1126\/science.276.5310.266","volume":"276","author":"Nesbitt SA","year":"1997","journal-title":"Science"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/BF01114813","volume":"9","author":"Datta HK","year":"1989","journal-title":"Biosci Rep"},{"key":"CIT0053","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1006\/bbrc.2000.2229","volume":"268","author":"Lorget F","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"CIT0054","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00774-008-0843-7","volume":"26","author":"Yamaguchi T","year":"2008","journal-title":"J Bone Miner Metab"},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1210\/endo.141.9.7634","volume":"141","author":"Udagawa N","year":"2000","journal-title":"Endocrinology"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000012303.37971.DA"},{"key":"CIT0057","unstructured":"Kumar V, Abbas A, Fausto N. Robbins and Cotran pathologic basis of disease. 7th edition. Elsevier Saunders, Philadelphia; 2005"},{"key":"CIT0058","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S8756-3282(01)00615-9","volume":"29","author":"Halasy-Nagy JM","year":"2001","journal-title":"Bone"},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1056\/NEJMoa0802633","volume":"360","author":"Weinstein RS","year":"2009","journal-title":"N Engl J Med"},{"key":"CIT0060","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.canlet.2007.07.007","volume":"257","author":"Stresing V","year":"2007","journal-title":"Cancer Lett"},{"key":"CIT0061","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1124\/mol.106.028837","volume":"71","author":"Ory B","year":"2007","journal-title":"Mol Pharmacol"},{"key":"CIT0063","first-page":"801","volume":"82","author":"Hill DA","year":"2010","journal-title":"Am Fam Physician"},{"key":"CIT0065","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.rdc.2010.03.003","volume":"36","author":"Karmakar S","year":"2010","journal-title":"Rheum Dis Clin North Am"},{"key":"CIT0066","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0002-9440(10)63016-7","volume":"159","author":"Pettit AR","year":"2001","journal-title":"Am J Pathol"},{"key":"CIT0067","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1172\/JCI0215582","volume":"110","author":"Redlich K","year":"2002","journal-title":"J Clin Invest"},{"key":"CIT0068","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1359\/jbmr.1999.14.9.1513","volume":"14","author":"Van bezooijen RL","year":"1999","journal-title":"J Bone Miner Res"},{"key":"CIT0069","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S8756-3282(00)00457-9","volume":"28","author":"Van Bezooijen RL","year":"2001","journal-title":"Bone"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061775"},{"key":"CIT0071","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.4049\/jimmunol.170.5.2655","volume":"170","author":"Lubberts E","year":"2003","journal-title":"J Immunol"},{"key":"CIT0072","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/rheumatology\/40.6.623","volume":"40","author":"Haynes DR","year":"2001","journal-title":"Rheumatology (Oxford)"},{"key":"CIT0073","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/46303","volume":"402","author":"Kong YY","year":"1999","journal-title":"Nature"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1002\/art.20384"},{"key":"CIT0075","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.semarthrit.2008.10.008","volume":"39","author":"Daoussis D","year":"2010","journal-title":"Semin Arthritis Rheum"},{"key":"CIT0076","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1136\/ard.2007.076711","volume":"67","author":"Gengenbacher M","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"CIT0077","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1196\/annals.1351.040","volume":"1069","author":"Seriolo B","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"CIT0078","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/ard.2007.076604","volume":"67","author":"Chopin F","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"CIT0079","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1002\/art.23417","volume":"58","author":"Cohen SB","year":"2008","journal-title":"Arthritis Rheum"},{"key":"CIT0080","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1136\/ard.2009.112920","volume":"69","author":"Dore RK","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20172"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20004"},{"issue":"415","key":"CIT0083","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1097\/01.blo.0000093055.96273.69","author":"Guise TA","year":"2003","journal-title":"Clin Orthop Relat Res"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1080\/01971520009349540"},{"key":"CIT0085","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1124\/jpet.102.035295","volume":"302","author":"Wood J","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0086","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1172\/JCI200422087","volume":"114","author":"Giraudo E","year":"2004","journal-title":"J Clin Invest"},{"issue":"2","key":"CIT0087","first-page":"933","volume":"28","author":"Soltau J","year":"2008","journal-title":"Anticancer Res"},{"key":"CIT0088","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1023\/A:1006513413583","volume":"16","author":"Stearns ME","year":"1998","journal-title":"Clin Exp Metastasis"},{"key":"CIT0089","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/j.1745-7254.2007.00607.x","volume":"28","author":"Lai TJ","year":"2007","journal-title":"Acta Pharmacol Sin"},{"key":"CIT0090","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/pbc.20019","volume":"42","author":"Cheng YY","year":"2004","journal-title":"Pediatr Blood Cancer"},{"key":"CIT0091","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF02966406","volume":"7","author":"Coleman RE","year":"2000","journal-title":"Breast Cancer"},{"key":"CIT0092","first-page":"7883","volume":"63","author":"Zhang J","year":"2003","journal-title":"Cancer Res"},{"key":"CIT0093","first-page":"2572","volume":"61","author":"Oyajobi BO","year":"2001","journal-title":"Cancer Res"},{"key":"CIT0094","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1172\/JCI11685","volume":"107","author":"Zhang J","year":"2001","journal-title":"J Clin Invest"},{"key":"CIT0095","first-page":"1619","volume":"62","author":"Holen I","year":"2002","journal-title":"Cancer Res"},{"key":"CIT0096","first-page":"4432","volume":"61","author":"Morony S","year":"2001","journal-title":"Cancer Res"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.13.3534"},{"key":"CIT0098","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/74999","volume":"6","author":"Honore P","year":"2000","journal-title":"Nat Med"},{"key":"CIT0099","first-page":"4038","volume":"61","author":"Luger NM","year":"2001","journal-title":"Cancer Res"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-007-9127-1"},{"key":"CIT0101","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0022-1759(99)00137-4","volume":"231","author":"Green LL","year":"1999","journal-title":"J Immunol Methods"},{"issue":"1","key":"CIT0102","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/ar2171","volume":"9","author":"Schwarz EM","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"CIT0103","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1200\/JCO.2007.11.8604","volume":"25","author":"Lipton A","year":"2007","journal-title":"J Clin Oncol"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.00803.x"},{"key":"CIT0105","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1158\/1078-0432.CCR-05-1933","volume":"12","author":"Body JJ","year":"2006","journal-title":"Clin Cancer Res"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4130"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70010-3"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62959-8"},{"key":"CIT0109","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S1470-2045(10)70059-0","volume":"11","author":"Kyrgidis A","year":"2010","journal-title":"Lancet Oncol"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70170-4"}],"container-title":["Expert Opinion on Therapeutic Targets"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14728222.2011.546351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T12:24:59Z","timestamp":1740831899000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/14728222.2011.546351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,5]]},"references-count":108,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,11,12]]},"published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1517\/14728222.2011.546351"],"URL":"https:\/\/doi.org\/10.1517\/14728222.2011.546351","relation":{},"ISSN":["1472-8222","1744-7631"],"issn-type":[{"value":"1472-8222","type":"print"},{"value":"1744-7631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,5]]}}}