{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:11:32Z","timestamp":1789884692684,"version":"4.0.1"},"reference-count":54,"publisher":"Informa UK Limited","issue":"12","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Targets"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1517\/14728222.2014.956087","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:05:53Z","timestamp":1770894353000},"page":"1449-1459","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Targeting FXR in cholestasis: hype or hope"],"prefix":"10.1517","volume":"18","author":[{"given":"Stefano","family":"Fiorucci","sequence":"first","affiliation":[{"name":"University of Perugia, Dipartimento di Scienze Chirurgiche e Biomediche, Sezione di Gastroenterologia, Nuova Facolt\u00e0 di Medicina e Chirurgia","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Distrutti","sequence":"additional","affiliation":[{"name":"S.C Gastroenterologia, Azienda Ospedaliera di Perugia","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Ricci","sequence":"additional","affiliation":[{"name":"University of Perugia, Dipartimento di Scienze Chirurgiche e Biomediche","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Giuliano","sequence":"additional","affiliation":[{"name":"S.C Gastroenterologia, Azienda Ospedaliera di Perugia","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annibale","family":"Donini","sequence":"additional","affiliation":[{"name":"University of Perugia, Dipartimento di Scienze Chirurgiche e Biomediche","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Baldelli","sequence":"additional","affiliation":[{"name":"University of Perugia, Dipartimento di Medicina Clinica","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,9,9]]},"reference":[{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2003.11.006"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.06.001"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.08.001"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1362"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1365"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80348-2"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051014398"},{"key":"e_1_3_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070477"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02550-0"},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009689"},{"key":"e_1_3_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112901108"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.005355"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.012104"},{"key":"e_1_3_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00154-5"},{"key":"e_1_3_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00187-9"},{"key":"e_1_3_1_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1083503"},{"key":"e_1_3_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.09.001"},{"key":"e_1_3_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e328324f87e"},{"key":"e_1_3_1_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030443"},{"key":"e_1_3_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2011.01.008"},{"key":"e_1_3_1_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64551"},{"issue":"2","key":"e_1_3_1_24_1","first-page":"109","article-title":"Plasma bile acid levels and liver disease","volume":"38","author":"Magyar I","year":"1981","unstructured":"Magyar I, Loi HG, Feher T. Plasma bile acid levels and liver disease. Acta Med Acad Sci Hung 1981;38(2):109-15","journal-title":"Acta Med Acad Sci Hung"},{"key":"e_1_3_1_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/213093b0"},{"key":"e_1_3_1_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5946.693"},{"issue":"5","key":"e_1_3_1_27_1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1001\/archderm.1974.01630050024005","article-title":"Pruritus induced by crude bile and purified bile acids. Experimental production of pruritus in human skin","volume":"109","author":"Varadi DP","year":"1974","unstructured":"Varadi DP. Pruritus induced by crude bile and purified bile acids. Experimental production of pruritus in human skin. Arch Dermatol 1974;109(5):678-81","journal-title":"Arch Dermatol"},{"key":"e_1_3_1_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01458.x"},{"issue":"1","key":"e_1_3_1_29_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000078632","article-title":"Itch-scratch responses induced by lysophosphatidic acid in mice","volume":"72","author":"Hashimoto T","year":"2004","unstructured":"Hashimoto T, Ohata H, Momose K. Itch-scratch responses induced by lysophosphatidic acid in mice. Pharmacol 2004;72(1):51-6","journal-title":"Pharmacol"},{"key":"e_1_3_1_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.05.009"},{"key":"e_1_3_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.05.002"},{"key":"e_1_3_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.05.002"},{"key":"e_1_3_1_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm025529g"},{"key":"e_1_3_1_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm401873d"},{"key":"e_1_3_1_35_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.12.41"},{"key":"e_1_3_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2210-7401(12)70015-3"},{"key":"e_1_3_1_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.06.052"},{"key":"e_1_3_1_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182802893"},{"key":"e_1_3_1_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.03.053"},{"key":"e_1_3_1_40_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.12.80"},{"key":"e_1_3_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260216"},{"key":"e_1_3_1_42_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2049"},{"key":"e_1_3_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2011.06.012"},{"key":"e_1_3_1_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18945"},{"key":"e_1_3_1_45_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.079665"},{"key":"e_1_3_1_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604772103"},{"key":"e_1_3_1_47_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500427-JLR200"},{"key":"e_1_3_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2003.12.001"},{"key":"e_1_3_1_49_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.08.001"},{"issue":"6","key":"e_1_3_1_50_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.2174\/156802612799436678","article-title":"Development of FXR, PXR and CAR agonists and antagonists for treatment of liver disorders","volume":"12","author":"Fiorucci S","year":"2012","unstructured":"Fiorucci S, Zampella A, Distrutti E. Development of FXR, PXR and CAR agonists and antagonists for treatment of liver disorders. Curr Top Med Chem 2012;12(6):605-24","journal-title":"Curr Top Med Chem"},{"issue":"1","key":"e_1_3_1_51_1","first-page":"357A","article-title":"Farnesoid - X receptor agonists: a new class of drugs for the treatment of PBC? An international study evaluating the addition of obeticholic acid (INT-747) to ursodeoxycholic acid [abstract]","volume":"52","author":"Mason L","year":"2010","unstructured":"Mason L, Luketic VA, Lindor KD, et al. Farnesoid - X receptor agonists: a new class of drugs for the treatment of PBC? An international study evaluating the addition of obeticholic acid (INT-747) to ursodeoxycholic acid [abstract]. Hepatology 2010;52(Suppl 1):357A","journal-title":"Hepatology"},{"key":"e_1_3_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(11)60030-5"},{"key":"e_1_3_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(12)60976-3"},{"key":"e_1_3_1_54_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2014.873404"},{"issue":"11","key":"e_1_3_1_55_1","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1016\/j.bmc.2014.04.014","article-title":"Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor","volume":"22","author":"Yu DD","year":"2014","unstructured":"Yu DD, Lin W, Forman BM, Chen T. Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg Med Chem 2014;Jun;1;22(11):2919-38","journal-title":"Bioorg Med Chem"},{"key":"e_1_3_1_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68815"}],"container-title":["Expert Opinion on Therapeutic Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14728222.2014.956087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:05:55Z","timestamp":1770894355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1517\/14728222.2014.956087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,9]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1517\/14728222.2014.956087"],"URL":"https:\/\/doi.org\/10.1517\/14728222.2014.956087","relation":{},"ISSN":["1472-8222","1744-7631"],"issn-type":[{"value":"1472-8222","type":"print"},{"value":"1744-7631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,9]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2014-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}