{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:02:38Z","timestamp":1784037758532,"version":"3.55.0"},"reference-count":131,"publisher":"Informa UK Limited","issue":"6","funder":[{"name":"MINECO","award":["SAF-2014-5040-P"],"award-info":[{"award-number":["SAF-2014-5040-P"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Targets"],"published-print":{"date-parts":[[2016,6,2]]},"DOI":"10.1517\/14728222.2016.1131269","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T01:43:16Z","timestamp":1449884596000},"page":"653-661","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":33,"title":["Intracellular and extracellular microtubule associated protein tau as a therapeutic target in Alzheimer disease and other tauopathies"],"prefix":"10.1517","volume":"20","author":[{"given":"Jes\u00fas","family":"Avila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noem\u00ed","family":"Pallas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Bol\u00f3s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Laura","family":"Sayas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"key":"CIT0001","volume-title":"Ciba foundations symposium - principles of biomolecular organization","author":"Porter KR.","year":"1996"},{"key":"CIT0002","volume-title":"Microtubules (Second Totally Revised Edition)","author":"Dustin P","year":"1984"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4054.1104"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.5.1858"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(86)90033-1"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1038\/ng.193"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.169"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1042\/BST20120063"},{"issue":"2","key":"CIT0009","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/j.1460-2075.1989.tb03390.x","volume":"8","author":"Goedert M","year":"1989","journal-title":"Embo J"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00024.2003"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2009.01.003"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)81066-9"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2555"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417548111"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400992101"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02999-X"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1038\/nature13999"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9503"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1038\/21650"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0126"},{"key":"CIT0021","first-page":"43","volume-title":"Brain microtubule associated proteins","author":"Kosik KS","year":"1997"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.03.032"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78421"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90276-4"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.356"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.036"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.5.1327"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007583214722"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.199976"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(77)90213-3"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1021\/bi00035a017"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1038\/343461a0"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.6.2739"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq521"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1038\/369488a0"},{"issue":"6","key":"CIT0036","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1242\/jcs.114.6.1179","volume":"114","author":"Dawson HN","year":"2001","journal-title":"J Cell Sci"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.5.989"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2613"},{"issue":"2","key":"CIT0039","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3233\/JAD-2010-100285","volume":"21","author":"Cantero JL","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-29"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1042\/bj2690061"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.11.030188.000333"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10161"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(90)90013-E"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2679"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.05.022"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200807179"},{"key":"CIT0048","author":"Sayas CL","year":"2015","journal-title":"J Neurochem"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.76"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.115.2.381"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.1.127"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt088"},{"issue":"3","key":"CIT0053","first-page":"497","volume":"137","author":"Barton AJ","year":"1990","journal-title":"Am J Pathol"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb09432.x"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.4.711"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi241"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt268"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00893-9"},{"key":"CIT0059","author":"Desikan RS","year":"2015","journal-title":"Mol Psychiatry"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30951"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)00972-1"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.07.004"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.11.022"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02323-1"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500466102"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2007.00568.x"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31817275c7"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3700"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1255"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.02.014"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1065-09.2009"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1038\/nm0796-783"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.121119298"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001087"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4913"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"issue":"4","key":"CIT0077","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3233\/JAD-2008-14411","volume":"14","author":"Bretteville A","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070193"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1007\/BF00309621"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1038\/nature08890"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.157"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1021\/bi061359o"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2005.11.009"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5245-10.2011"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318807111"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411649111"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031302"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.11.033"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.07.078"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2007.12.010"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054625"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.037"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2681-7"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3809"},{"key":"CIT0095","author":"Marquie M","year":"2015","journal-title":"Ann Neurol"},{"issue":"24","key":"CIT0096","doi-asserted-by":"crossref","first-page":"9713","DOI":"10.1523\/JNEUROSCI.21-24-09713.2001","volume":"21","author":"Potter SM","year":"2001","journal-title":"J Neurosci"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1021\/jm5005623"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.130526"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.02.011"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.2174\/156720510793611628"},{"issue":"13","key":"CIT0101","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1523\/JNEUROSCI.19-13-05245.1999","volume":"19","author":"Tatebayashi Y","year":"1999","journal-title":"J Neurosci"},{"key":"CIT0102","author":"Liu H","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092136199"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141736"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1126\/science.1252967"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-113795"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200802621"},{"issue":"2","key":"CIT0109","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3233\/JAD-142874","volume":"44","author":"Wischik CM","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.07.005"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.436402"},{"issue":"1","key":"CIT0112","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3233\/JAD-2012-120805","volume":"33","author":"Del Ser T","year":"2013","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"CIT0113","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/JAD-141959","volume":"45","author":"Lovestone S","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04606"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702793200"},{"key":"CIT0116","author":"Tsai SY","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb03603.x"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709852200"},{"key":"CIT0119","author":"Kaufman AC","year":"2015","journal-title":"Ann Neurol"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4363-10.2010"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-009-9355-9"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12845"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4989-14.2015"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa2512"},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3617"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt108"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70119-8"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.616029"},{"key":"CIT0129","author":"Pedersen JT","year":"2015","journal-title":"Trends Mol Med"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3951"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1931"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1901"}],"container-title":["Expert Opinion on Therapeutic Targets"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14728222.2016.1131269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T02:06:50Z","timestamp":1653790010000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/14728222.2016.1131269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,16]]},"references-count":131,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,12,19]]},"published-print":{"date-parts":[[2016,6,2]]}},"alternative-id":["10.1517\/14728222.2016.1131269"],"URL":"https:\/\/doi.org\/10.1517\/14728222.2016.1131269","relation":{},"ISSN":["1472-8222","1744-7631"],"issn-type":[{"value":"1472-8222","type":"print"},{"value":"1744-7631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,16]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}