{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:56:10Z","timestamp":1761742570067},"reference-count":40,"publisher":"Informa Healthcare","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Opinion on Therapeutic Targets"],"published-print":{"date-parts":[[2002,12]]},"DOI":"10.1517\/14728222.6.6.679","type":"journal-article","created":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T03:23:50Z","timestamp":1115263430000},"page":"679-689","source":"Crossref","is-referenced-by-count":22,"title":["Emerging techniques for the discovery and validation of therapeutic targets for skeletal diseases"],"prefix":"10.1517","volume":"6","author":[{"given":"Christine H","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E","family":"Nuttall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3197","published-online":{"date-parts":[[2005,2,25]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1359-6446(01)02140-7","volume":"7","author":"JOHNSTON PA","year":"2002","journal-title":"Drug Disc. Today"},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1367-5931(97)80003-8","volume":"1","author":"VEBER DF","year":"1997","journal-title":"Curr. Opin. Chem. Biol."},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1021\/jm00036a001","volume":"37","author":"GORDON EM","year":"1994","journal-title":"j. Med. Chem."},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0022-1759(01)00304-0","volume":"250","author":"ALT M","year":"2001","journal-title":"j. Immunol. Methods"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1053\/joca.1999.0295","volume":"8","author":"WANG FL","year":"2000","journal-title":"Osteoarthritis Cartilage"},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"12511","DOI":"10.1074\/jbc.271.21.12511","volume":"271","author":"DRAKE FH","year":"1996","journal-title":"j. Biol. Chem."},{"key":"CIT0014","first-page":"12517","volume":"271","author":"BOSSARD MJ","year":"1996","journal-title":"THOMPSON SK etal.: Proteolytic activity of human osteoclast cathepsin K. j Biol. Chem."},{"key":"CIT0015","first-page":"679","volume":"380","author":"XIA L","year":"1999","journal-title":"Biol. Chem."},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1359\/jbmr.1999.14.10.1654","volume":"14","author":"GOWEN M","year":"1999","journal-title":"j. Bone Nliner. Res."},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"14249","DOI":"10.1073\/pnas.94.26.14249","volume":"94","author":"THOMPSON SK","year":"1997","journal-title":"Proc. Natl. Acad. Sd. USA"},{"key":"CIT0019","first-page":"1739","volume":"16","author":"STROUP GB","year":"2001","journal-title":"VEBER DF etal.: Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate. j. Bone Miner. Res."},{"key":"CIT0021","first-page":"137","volume":"234","author":"TSUDA E","year":"1997","journal-title":"MOCHIZUKI S etal.: Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem. Biophys. Res. Commun."},{"key":"CIT0022","first-page":"309","volume":"89","author":"SIMONET WS","year":"1997","journal-title":"DL,DUNSTAN CR et al.: Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell"},{"key":"CIT0023","first-page":"602","volume":"11","author":"COCKETT M","year":"2000","journal-title":"Cum: Opin. Biotech."},{"key":"CIT0025","first-page":"1260","volume":"12","author":"BUCAY N","year":"1998","journal-title":"DUNSTAN CR etal.: Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev."},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8697"},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"LACEY DL","year":"1998","journal-title":"Cell"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","volume":"95","author":"YASUDA H","year":"1998","journal-title":"Natl. Acad. Sci. USA"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.40.25190"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/36593","volume":"390","author":"ANDERSON MA","year":"1997","journal-title":"Nature."},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1073\/pnas.96.7.3540","volume":"96","author":"HSU HL","year":"1999","journal-title":"Proc. Natl. Acad. Sri. USA"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1359\/jbmr.1999.14.9.1478","volume":"14","author":"MORONEY S","year":"1999","journal-title":"_J. Bone Miner. Res."},{"key":"CIT0034","first-page":"817","volume":"44","author":"ELLIS HM","year":"1986","journal-title":"Genetic control of programmed cell death in the nematode C elegans Cell"},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"16007","DOI":"10.1074\/jbc.275.21.16007","volume":"270","author":"LEE D","year":"2000","journal-title":"J. Biol. Chem."},{"key":"CIT0037","first-page":"245","volume":"25","author":"KOURI JB","year":"1997","journal-title":"Med. Sri. Res."},{"key":"CIT0038","first-page":"75","volume":"146","author":"BLANCO FJ","year":"1995","journal-title":"Am. J. Pathol."},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/1529-0131(199809)41:9<1632::AID-ART14>3.0.CO;2-A","volume":"41","author":"HASHIMOTO S","year":"1998","journal-title":"Arthritis Rheum."},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2106\/00004623-197153030-00009","volume":"53","author":"MANKIN H","year":"1971","journal-title":"I Bone Joint. Surg."},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00427-0"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00020-4"},{"key":"CIT0044","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0092-8674(91)90499-O","volume":"64","author":"SORIANO P","year":"1991","journal-title":"Cell"},{"key":"CIT0046","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1389-0344(01)00097-1","volume":"18","author":"NYMAN TA","year":"2001","journal-title":"Biomol. Eng."},{"key":"CIT0047","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1006\/bbrc.2002.6678","volume":"292","author":"ISSAQ HJ","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1359-6446(02)02173-6","volume":"7","author":"AUGEN J","year":"2002","journal-title":"Drug Disc. Today"},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1073\/pnas.042684599","volume":"99","author":"YEE A","year":"2002","journal-title":"Proc. Nat. Acad. Li. USA"},{"key":"CIT0053","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0076-6879(83)01012-5","volume":"101","author":"ROSE M","year":"1983","journal-title":"Methods Erizymol."},{"key":"CIT0054","doi-asserted-by":"crossref","first-page":"9578","DOI":"10.1073\/pnas.88.21.9578","volume":"88","author":"CHIEN CT","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"CIT0056","first-page":"659","volume":"9","author":"MCDONNELL DP","year":"1995","journal-title":"Mol. Eridocrinol."},{"key":"CIT0057","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0014-5793(96)00782-X","volume":"392","author":"MOSSELMANN S","year":"1996","journal-title":"FEBS Lett"},{"key":"CIT0058","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1001\/jama.1996.03540170033029","volume":"276","author":"THE WRITING GROUP FOR THE PEPI TRIAL","year":"1996","journal-title":"J. Am. Merl Assoc."}],"container-title":["Expert Opinion on Therapeutic Targets"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1517\/14728222.6.6.679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T18:57:57Z","timestamp":1550429877000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1517\/14728222.6.6.679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,2,25]]},"published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1517\/14728222.6.6.679"],"URL":"https:\/\/doi.org\/10.1517\/14728222.6.6.679","relation":{},"ISSN":["1472-8222","1744-7631"],"issn-type":[{"value":"1472-8222","type":"print"},{"value":"1744-7631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}